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Staff Listing 

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Charles Laughton

Professor of Computational Pharmaceutical Science, Faculty of Science

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Biography

My first degree was in Chemistry, and I then stayed on at Oxford to study for my DPhil with George Fleet on the total synthesis of analogues of the antimycoplasmic agent pseudomonic acid. I then moved to the CRC Experimental Cancer Chemotherapy Research Group at Aston University, working with Andy Gescher, John Hickman and Malcolm Stevens on protein kinase C inhibitors as antitumour agents. This awakened an interest in both cancer chemotherapy and computational chemistry. I next moved to the CRC Biomolecular Structure Unit at the Institute of Cancer Research, where with Stephen Neidle I was able to pursue molecular modeling full time, and also developed a particular interest in nucleic acid structure and recognition. In 1995 I took up a lectureship in the School of Pharmacy at Nottingham, and was promoted to Reader in 2001.

Teaching

Practical Pharmaceutical ChemistryPharmaceutical and Biological ChemistryMedicinal Chemistry and Drug Design

Research Summary

My research focuses on the understanding of molecular recognition in biological systems, and the application of this to projects in medicinal chemistry, particularly the development of novel… read more

Recent Publications

Current Research

My research focuses on the understanding of molecular recognition in biological systems, and the application of this to projects in medicinal chemistry, particularly the development of novel anticancer agents. My core research specialism is computational chemistry, and more specifically molecular dynamics simulations of biological macromolecules (proteins and nucleic acids) and their complexes with each other and with small ligands. For this work we make use of, and develop software for, some of the largest computational facilities in the world, including the UK national service (ARCHER) and the US service (XSEDE). Current work includes the development and application of new in silico drug screening methods (with Ludo Dekker, Peter Fischer, Weng Chan and Barrie Kellam), studies on polymer-drug interactions (with Martin Garnett, Jonathan Burley and Cameron Alexander), and studies on nucleic acid structure and recognition (with Modesto Orozco at Barcelona, and Sarah Harris at Leeds).

Memberships of Committees and Professional Bodies

  • Member of the Royal Society of Chemistry (& Chartered Chemist)
  • Member of the executive committee of the EPSRC Collaborative Computational Project for Biomolecular Simulation (CCP-BioSim)
  • Member of the executive committee of the EPSRC High-End Computing Consortium for Biomolecular Simulation (HECBiosim)
  • Member, ARCHER Embedded Computational Science and Engineering Support Panel.

School of Pharmacy

University of Nottingham
University Park
Nottingham, NG7 2RD

For all enquiries please visit:
www.nottingham.ac.uk/enquiry