I am a Chemist by training and obtained both my BSc and PhD from the University of London. My postgraduate research was in the area of electroorganic synthesis, after which I moved into structural organic chemistry, utilizing primarily computational approaches, supported as required by experimental data. I have a wide range of experience in structural chemistry, involving systems varying from small organic molecules, including studies of nitrogen geometry in anilines, to micelle structure in drug delivery systems, and stationary phases in separation science. More recently my work has concentrated on protein/ligand interactions.
I have worked as a consultant in visual science communication, with a variety of organizations including the BBC, Nesta, EPSRC (Engineering and Physical Sciences Research Council) and the RSC (Royal Society of Chemistry). I have been involved in exhibition design and development (prior to fit-out) at the interactive science centre Explore in Bristol, I chaired the Royal Society of Chemistry Committee for Promoting Chemistry to the Public and I was awarded the Science Communicator Award from the BBSRC (Biotechnology and Biological Sciences Research Council).
Major pieces of work that I have completed, include:
Small Matters, a series of short films highlighting the role of molecules in enjoyment and pleasure, which have been broadcast on BBC television, and exhibited in venues across the UK;
Lighting-up the Invisible, a collection of interior lighting products exploring molecular shape and architectures, which has been exhibited at the Royal College of Art, London and at 100% Design Earls Court, London;
Sense-ational, an exhibition of photographs showing the role of molecules in everyday life, which has been exhibited at venues across the UK, including the Royal Society of Chemistry, Burlington House, London.
My research interests focus on the study of proteins and their interactions using both experimental and computational techniques. These studies range from exploring how proteins crystallize, and how… read more
DUFOUR, M., YAN, C., SIEGEL, D., COLUCCI, M.A., JENNER, M., OLDHAM, N.J., GOMEZ, J., REIGAN, P., LI, Y., DE MATTEIS, C.I., ROSS, D. and MOODY, C.J., 2011. Mechanism-based inhibition of quinone reductase 2 (NQO2): selectivity for NQO2 over NQO1 and structural basis for flavoprotein inhibition ChemBioChem. 12(8), 1203-1208
DE MATTEIS, C.I., SIMPSON, D.A., DOUGHTY, S.W., EUERBY, M.R., SHAW, P.N. and BARRETT, D.A., 2010. Chromatographic retention behaviour of n-alkylbenzenes and pentylbenzene structural isomers on porous graphitic carbon and octadecyl-bonded silica studied using molecular modelling and QSRR Journal of Chromatography. A. 1217(44), 6987-6993
My research interests focus on the study of proteins and their interactions using both experimental and computational techniques. These studies range from exploring how proteins crystallize, and how their crystallization can be improved, to studies of ligand binding to enzymes, including an exploration of chemical mechanism at the active site. My work utilizes a combination of experimental techniques, including X-ray crystallography, and NMR spectroscopy and computational approaches, including virtual screening.
Current studies include structural and mechanistic studies of the oxido-reductase flavoprotein quinone reductase 2 (NQO2), and structure-based drug design studies involving a variety of anti-tuberculosis target enzymes.
My educational research interests are in the area of integrated learning, in particular the integration of science with clinical practice, and in the context-based teaching of science.