Contact
Biography
Dr Dong-Hyun Kim was appointed as Assistant Professor in Analytical Bioscience in the School of Pharmacy, the University of Nottingham in October 2013 and promoted to Associate Professor in 2020. Prior to this position he conducted postdoctoral research on clinical metabolomics of trypanosomes in Glasgow Biomedical Research Centre at the University Glasgow (2010-2013) after four years in the School of Chemistry at the University of Manchester obtaining his PhD (2006-2010), which involved applications of analytical instruments for the investigation of cervical cancer. He is Director of the Centre for Analytical Bioscience which is a successful mass spectrometry (MS) facility that now houses extensive specialist mass spectrometry instrumentation including high resolution MS (Thermo Exactive and QExactive Orbitrap), ion trap MS (Thermo LTQ Velos) and quadruple linear ion trap MS (QTRAP 4000 and 6500). This facility provides the high-quality research environment for metabolomics, lipidomics, fluxomics, metabolic pathway profiling, and biomarker identification analysis. His role includes coordination of internal and external project work as well as fostering interdisciplinary applications of MS-based analytical techniques. He is also Associate Director of the Nottingham Green Chemicals Beacon of Excellence - a multi-disciplinary investment (£17m) in sustainable processing encompassing industrial biotechnology, process engineering and green chemistry. His research career has focused on the advancement and application of MS-based methods in order to solve scientific problems across the engineering/physical/life sciences disciplines.
Expertise Summary
Mass spectrometry applied to pharmaceutical, life and biomedical sciences research
i) Biomarker discovery of disease - global metabolite profiling using metabolomics and lipidomics methods
ii) Metabolic pathway profiling - targeted analysis of metabolites, stable isotope assisted analysis
iii) Surface mass spectrometry anaysis of biological samples (e.g. tissue, cell, organism)
Teaching Summary
MPharm/Pharm Sci/Int Pharm
- Dyspepsia (MPharm) - Module convenor
- Research Projects (MPharm/Pharm Sci/Int Pharm) - Module convenor
- Medical Diagnostics (MPharm) - Co-module convenor
- Natural Products (Pharm Sci) - Module contributor
Research Summary
Dr Dong-Hyun Kim's research career has focused on the advancement and application of mass spectrometry (MS)-based methods in order to investigate complex samples and matrices in… read more
Selected Publications
MEURS, JORIS, SCURR, DAVID, LOURDUSAMY, ANBARASU, STORER, LISA, GRUNDY, RICHARD, ALEXANDER, MORGAN, RAHMAN, RUMAN and KIM, DONG-HYUN, 2021. Sequential 3D OrbiSIMS and LESA-MS/MS-based
metabolomics for prediction of brain tumor relapse from
sample-limited primary tissue archives Analytical Chemistry. 93(18), 6947-6954 TOMI-ANDRINO C, NORMAN R, MILLAT T, SOUCAILLE P, WINZER K, BARRETT DA, KING J AND KIM D-H, 2021. Physicochemical and metabolic constraints for thermodynamics-based stoichiometric modelling under mesophilic growth conditions. PLOS Computational Biology. 17(1), e1007694 WOODWARD, ALISON, PANDELE, ALINA, ABDELRAZIG, SALAH, ORTORI, CATHERINE A., KHAN, IQBAL, URIBE, MARCOS CASTELLANOS, MAY, SEAN, BARRETT, DAVID A., GRUNDY, RICHARD G., KIM, DONG-HYUN* and RAHMAN, RUMAN*, 2021. Integrated Metabolomics and Transcriptomics Using an Optimised Dual Extraction Process to Study Human Brain Cancer Cells and Tissues Metabolites. 11(4), 240 *Joint corresponding authors ABDELRAZIG, SALAH, SAFO, LAUDINA, RANCE, GRAHAM A., FAY, MICHAEL W., THEODOSIOU, EIRINI, TOPHAM, PAUL D., KIM, DONG-HYUN* and FERNÁNDEZ-CASTANÉ, ALFRED*, 2020. Metabolic characterisation of Magnetospirillum gryphiswaldense MSR-1 using LC-MS-based metabolite profiling RSC Advances. 10, 32548-32560 *Joint corresponding authors
Current Research
Dr Dong-Hyun Kim's research career has focused on the advancement and application of mass spectrometry (MS)-based methods in order to investigate complex samples and matrices in life/physical/biomedical sciences. He has been particularly interested in employing isotopically labelled compounds to enable accurate metabolic pathway analysis and to enhance the reproducibility and quantitation of MS-based methods including untargeted metabolite profiling and ambient surface analysis.
His research areas are:
• Biomarker of disease / drug discovery using MS-based global metabolite profiling
• Metabolic pathway profiling (targeted and stable isotope assisted analysis)
• Surface mass spectrometry analysis of biological samples (e.g. tissue, cell, organism)
• Absolute quantification using heavy atom labelled organism
• Metabolic flux analysis
His current research grants are:
• OPERA -orif mechanistic negotiation (National Institute for Health Research)
• Targeting glioblastoma drug resistance through RNA methylation (The Brain Tumour Charity)
• Harnessing the potential of 17-HDHA a novel biomarker of OA pain status (Arthritis Research UK)
• Exploring alterations in amino acid metabolism as novel therapeutic targets in paediatric glial tumours using advanced metabolomics methods (Little Princess Trust Project Grant, CCLG Children's Cancer and Leukaemia Group)
• Hijacking plant immunity: winners and losers in dual pest and pathogen attacks on a shared host (BBRSC)
• Disrupting cancer metabolism to improve therapy for childhood ependymoma (Stoneygate Catalyst Award, Stoneygate Children's Brain Tumour Research Fund)
• Brain distribution models to select polymer-delivered drugs for the treatment of childhood brain cancers (Little Princess Trust Project Grant, CCLG Children's Cancer and Leukaemia Group)