School of Pharmacy
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Maria Marlow

Associate Professor, Faculty of Science

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Biography

I am pharmacist with a PhD in drug delivery (University of Nottingham 1991) and post doctoral experience in tissue engineering (Massachusetts Institute of Technology 1991-1992) working with osteoblasts and biodegradable polymers. I have over 18 years experience in drug delivery in industry and have worked on many different drug delivery options and formulations throughout my career at Fisons, Astra and then AstraZeneca including oral, intravenous and inhaled dosage forms. Specifically I worked on AstraZeneca's metered dose inhaler SYMBICORT, for which I have a formulation patent. I have also developed formulations of poorly soluble candidate drugs. My industrial experience includes several scientific and line manager roles from 1996 leading multidisciplinary teams in product development and early development. My last industrial role in early development included the development of formulations for preclinical, toxicity and phase I/II studies. I have also project managed and led numerous technical improvement projects/teams including recently in 2010, the development of a new global process for suspension development and a global web based brochure for clinical supplies.

In May 2011, I made the transition back into academia and secured the first Gunn and Carter Senior Fellowship at De Montfort University working with Dr Geoff Smith on developing methodologies for studying bio-relevant physical form changes of drug products using terahertz spectroscopy and pulsed imaging. In Jan 2012, I was appointed as Associate Professor in Formulation Science and Pharmaceutical Materials in the School of Pharmacy. Currently I am the deputy director of the EPSRC CDT in Advanced Therapeutics and Nanomedicine and supervise 4 PhD students and cosupervise 3 students. I am also a committee member of the United Kingdom and Ireland Controlled Release Society and the Academy of Pharmaceutical Science Parenteral Focus group.

Expertise Summary

Drug delivery

Formulation science

Material characterisation

Teaching Summary

Pharmaceutics

MPharm -1st year physical stability of medicines (B31ESP) & quality assurance (B31BPH); 2nd year controlled drug release and colloidal stability (B32PAI)

MSc Drug Discovery and Pharmaceutical Sciences -Formulations in drug discovery and development

Research Summary

My research interests are focused on developing drug delivery systems that address an unmet clinical need in collaboration with clinicians. Current research projects use supramolecular hydrogels and… read more

Selected Publications

Current Research

My research interests are focused on developing drug delivery systems that address an unmet clinical need in collaboration with clinicians. Current research projects use supramolecular hydrogels and are focused on cancer therapy. They include the self -assembly of prodrug gelators for localised delivery improving the therapeutic outcomes of existing drugs; analysis and improvement of drug permeation in basal cell carcinoma; and modulation of cancer cell adhesion to biomaterials. The research involves the physicochemical characterisation of these deliver systems to allow the prediction of their in vivo performance.

Future Research

Future resarch is based upon using nucleoside based supramolecular hydrogels for vaginal drug delivery, with nanocapsules for lymphatic targeting; for wound healing and for cell delivery in regenerative medicine.

School of Pharmacy

University of Nottingham
University Park
Nottingham, NG7 2RD

For all enquiries please visit:
www.nottingham.ac.uk/enquiry