Professor Kevin Sinclair

Professor of Developmental Biology and Head of Division of Animal Sciences

Phone: +44 (0) 115 951 6053

Email: kevin.sinclair@nottingham.ac.uk

Kevin is a member of the Future Food leadership team. Kevin's research interests lie in metabolic programming during early mammalian development, where epigenetic outcomes are determined in embryonic cells and tissues, and long-term developmental consequences assessed in offspring. His group were the first to discover that developmental anomalies following embryo culture, leading to Large Offspring Syndrome (LOS) in cattle and sheep, were due to errors in genomic imprinting. They were also first to demonstrate that reductions in folate and vitamin B12 in maternal diets (sheep and rats) lead to epigenetic modifications to DNA methylation associated with hypertensive and insulin-resistant offspring. They subsequently demonstrated that paternal malnutrition epigenetically modifies DNA methylation and adversely affects cardio-metabolic health in mouse offspring. Kevin's ongoing work is assessing the nature and extent of aneuploidy and epigenetic dysregulation during bovine embryo culture, and transgenerational epigenetic consequences of exposure to real-life mixtures of environmental chemicals in sheep grazing pastures treated with biosolids.