Our collaborative work with Michael Hsieh (BRI Rockville, MD) and Ted Jardetzy (Stanford, CA) has been published in FASEB Journal earlier this month. The paper describes the use of IPSE, a molecule released in large amounts by the eggs of the parasitic trematode Schistosoma haematobium, for the treatment of chemotherapy-induced cystitis. IPSE performed better than the conventional drug used for prevention of chemotherapy-induced cystitis, 2-mercaptoethane sulfonate sodium (MESNA). The precise mechanisms are currently under investigation.
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