Our Trematode Infiltrin paper published in the December 2017 Issue of Infection and Immunity (Vol 85(12)) has been selected for the 'Spotlight' section - 'Articles of Significant Interest Selected from This Issue by the Editor'
Behind Enemy Lines: Pathogen-Secreted Host Nucleus-Infiltrating Proteins (Infiltrins)
Many bacterial and protozoan pathogens have evolved subtle ways of subverting and escaping their host’s protective immune responses, mainly by adopting an intracellular lifestyle. Parasitic worms, such as Schistosoma haematobium, are too large to hide inside cells. Pennington et al. (e00301-17) describe how the parasite’s eggs, by secreting a glycoprotein called H-IPSE, may gain access to the innermost compartment of host cells, the nucleus, after crossing several biological barriers, such as the cytoplasmic, nuclear, and possibly also endosomal membranes—a surprising property which led the authors to introduce the name infiltrins for this class of proteins.
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