Biomaterials Discovery

Materials Today Bio 2020


Latest research into new strategies for immune modulation published

New strategies for immune modulation have shown real promise in regenerative medicine as well as the fight against autoimmune diseases, allergies, and cancer. Dendritic cells (DCs) are gatekeepers of the immune system and their ability in shaping the adaptive immune responses makes DCs ideal targets for immune modulation. In collaboration with the Gibson group at the University of Warwick, in this study we used a combinatorial library of monosaccharides to identify simple carbohydrates that are able to modulate human DC phenotype. Our data show that a selection of monosaccharides are able to induce regulatory DC phenotype and T cell phenotypes. 

These simple carbohydrate combinations (e.g. in combination with immune-instructive polymers) can be utilized as novel tools for immune modulation with potential applications in regenerative medicine, implantable medical devices, and wound healing where reduction of inflammatory responses and maintaining immune homeostasis are desirable.

The full article can be read in the Materials Today Bio journal.

Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties.
M.A.Alobaid, S.-J. Richards, M.R. Alexander, M.I.Gibson, A.M.Ghaemmaghami.
Materials Today Bio, Volume 8, September 2020, 100080

Posted on Wednesday 16th December 2020

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