Core Outcomes for Research in Lichen Sclerosus (CORALS)
Lichen sclerosus (LS) is a chronic genital condition which can cause significant symptoms, interferes with day to day life and has a substantial impact on quality of life.
The Core Outcomes for Research in Lichen Sclerosus (CORALS) project will establish the most important outcomes to measure in future trials of genital lichen sclerosus.
A recording of the project group meeting held in September 2021 is available to watch online.
Opportunity to Take Part
We have now completed all 3 rounds of the CORALS surveys. A huge thank you to everyone that participated!
Two virtual sessions were held in January 2022 to vote upon the final 'core domains' for future lichen sclerosus research studies. Further meetings will take place in the Summer 2022, so please watch this space.
We aim to involve a mixture of patients, patient representatives, health professionals and researchers from across the world in these meetings. If you would like to become involved in the CORALS project, please email email@example.com.
Participant Information Sheets
We have produced these participant information sheets in several different languages.
Why are we doing this project?
Published randomised controlled trials of treatments for LS use different ways of measuring response to treatments (outcomes). This prevents the results of trials from being combined. If trial results were combined, we would have stronger evidence on which to base treatment making decisions. The CORALS project aims to obtain international agreement on what aspects of disease (‘domains’) should be measured in clinical trials of LS. These core domains will subsequently inform an international ‘core outcome set’ for use in all future LS trials.
What will the research involve?
In this project we will:
1. Review the most up to date literature for lichen sclerosus to see what aspects of disease (‘domains’) have been measured previously. We will create a long list of domains.
2. Obtain consensus from international stakeholders (including patients, health professionals, researchers, journal editors, industry representatives) via an online survey on the most important of these domains to create a short list.
3. At a face-to-face meeting, agree the final outcome domains which are considered to be ‘core’ to all future trials of lichen sclerosus.
What will happen with the results?
The results of this work will be used to prepare the next steps of Core Outcome Set development. For each of the agreed core outcome domains, it needs to be established how best to measure the domain. Outcome measurement instruments therefore need to be selected. Once the final Core Outcome Set has been agreed, the hope is that researchers will use it in all studies for Lichen Sclerosus (researchers can still add in other outcomes if they wish). If all future studies have standardised outcomes in this way, their results can be combined and it will be easier to determine which treatments are best.
The results will be shared through networks with patient and professional groups, as well as presentation at conferences and publication in scientific journals.
Who is funding the project?
- UK Dermatology Trials Network (UK DCTN) (funders)
- International Society for study of Vulvovaginal Disease (ISSVD)
- British Society for Study of Vulval Disease (BSSVD)