Centre for Large Animal Biotechnology
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CeLAB

The Centre for Large Animal Biotechnology (CeLAB) carries out research aimed at enhancing the productivity and welfare of farm animals and to develop models of human development and disease. 

CeLAB utilizes and develops genomic resources and tools to improve the understanding of animal growth and development. Progress in these areas will fulfil the increasing demands for animal protein to feed a growing human world population, and contribute to Global Food Security. 

Human stem cells labelled  with a surface marker

 

 

Furthermore, because of the physiological similarities between humans and farm animals, research in farm animals contributes to improving our understanding of human development, the causes of genetic disorders, and ageing. CeLAB key research priority areas are addressed in the following 4 research themes: 

CeLAB Technologies

  • Gene editing, assisted reproduction, stem cell technologies, genomic evaluation and selection, bioinformatics.  

CeLAB Research Themes

  • Basic Biomedical Research: Comparative embryology, developmental epigenetics, cell differentiation and stem cell biology
  • Applied  Biomedical Research: Human models of kidney disorders, osteoarthritis, metabolic syndrome, biology of ageing
  • Animal Production: Improved feed efficiency, muscle growth, gut microbiome, reduced environmental impact 
  • Animal Health and Welfare: disease resistance, stress and immuno-competence

Current projects

  • Ontogeny of the germline in non-rodent mammals (BBSRC)
  • Gastrulation in humans and pigs (BBSRC)
  • Generation of gametes in vitro (Horizon2020)
  • Enhancing oocyte quality from peri-pubertal donors to promote biosecure and sustainable food production (BBSRC)
  • How does signalling induce human primordial germ cells? (MRC)
  • Novel targets for increased muscle growth or feed efficiency (BBSRC)
  • Urinary trace element profile as an early biomarker of acute kidney injury (NIHR)
  • Development of a Novel Anisotrophic Tissue Expander for Non-Keratinized Epithelial Tissue (BBSRC)
  • Novel targets to improve muscle growth and feed efficiency (BBSRC LINK grant with Zoetis)
  • Identification of non-invasive markers of gut turnover (AB Vista funded)
  • Does phytase activity generate inositol phosphates that have effects on animal growth? (AB Vista funded)
  • Role of xylo-oligosaccharides in feed efficiency (AB Vista funded)
More projects
  • Insects as intermediate “nutrient concentrators” for sustainable animal feeds (BBSRC DTP Industrial Challenge Strategy Fund with AB Agri/AB Vista)
  • The impact of exogenous enzymes added to feed on the chicken digestive system (AB Vista funded)
  • Practical Strategies to Increase Individual Layer Hen Feed Efficiency (FE) (Australian Eggs)
  • Salmonella control programs in commercial egg layers (Australian Eggs)
  • Administration of probiotics in pigs effect on phytase” (Protexin)
  • Effect of the prebiotic Galacto-Oligosaccharide (GOS) on the microbiome of weaning pigs” (Dairy Crest)
  • Investigating osteoarthritis and osteochondrosis in commercial pigs (BBSRC)
 

Research team

CeLAB Core Technologies Leaders

CeLAB Research Themes Leaders

Related global research


 

 

        

Centre for Large Animal Biotechnology

The University of Nottingham
Sutton Bonington Campus
Loughborough, LE12 5RD

telephone: +44 (0) 115 951 6302
email: Lorraine.sabin@Nottingham.ac.uk