Medicine Safety and Effective Healthcare Research

Work package 2: the CDS-software, OptimiseRx Intervention

Evaluating the effectiveness and cost-effectiveness of an intervention involving the introduction of a set of prescribing safety indicators to computerised clinical decision support (CDS) software (OptimiseRx) in reducing hazardous prescribing in general practices


  • Determine the effectiveness and cost effectiveness of the CDS-software, OptimiseRx, in reducing hazardous prescribing in general practices
  • Determine whether Optimise Rx is associated with a reduction in rates of hazardous prescribing, hospitalisation, and all-cause mortality
  • Determine the cost from the perspective of the NHS, and the incremental cost her hazardous prescribing event avoided
  • Determine the incremental cost for QALY generated by OptimiseRx for a subset of seven key prescribing indications (which are also used in WP3) 

Setting and participants

  • Setting: general practices in England that use TPP SystemOne and contribute to the ResearchOne database
  • Recruitment: all practices in ResearchOne have already consented for use of their data for research purposes


  • Design: interrupted time series study (24 months prior and 12 months post implementation)
  • Data collection: ResearchOne will provide pseudoanonymised data for practicing general practices. Data will need to be linked to HES and ONS


  • Primary: the number and proportion of patients in each general practice exposed to at least one type of hazardous prescribing
  • Secondary: rates of hospitalisation and all-cause mortality 

WP2 team members

  • Professor Niels Peek (Lead)
  • Professor Darren Ashcroft
  • Dr Sarah Armstrong
  • Professor Tony Avery
  • Professor Bruce Guthrie
  • Dr Pearl Mok
  • Dr Sarah Rodgers
  • Professor Tjeerd van Staa

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Medicine Safefy and Effective Healthcare Research

The University of Nottingham
School of Medicine

telephone: +44 (0) 115 823 0209