Simon Welham

Contact

• workRoom 24 North Laboratories
  Sutton Bonington Campus
  Sutton Bonington
  Leicestershire
  LE12 5RD
  UK
• work0115 951 6129
• fax0115 951 6122
• simon.welham@nottingham.ac.uk

Research Summary

Fetal programming.

Exposure to maternal undernutrition in early life directly impacts upon fetal growth and development and permanently alters postnatal physiology. This has been demonstrated to predispose individuals towards cardiovascular disease, diabetes and obesity in adulthood. An important aspect of these phenotypes is that they are both permanent and worsen with age. My current research seeks to examine the role of epigenetic modifications, most notably DNA methylation, brought about by in utero exposure to maternal undernutrition, in programming insulin resistance and how this might be modulated by ageing. In addition, I am also interested in understanding the mechanisms by which fetal growth impairment results in alterations in cellular determination during development.

Recent Publications

• LANGLEY-EVANS, SIMON C, DANIEL, ZOE C, WELLS, CATHY A, RYAN, KEVIN J P, PLANT, RICHARD and WELHAM, SIMON J M, 2010. Protein restriction in the pregnant mouse modifies fetal growth and pulmonary development: role of fetal exposure to beta-hydroxybutyrate. Experimental physiology. 96, 203-215
• WELHAM, SIMON J M, 2010. Programmed repression of tubular 11{beta}-HSD2--a novel form of AME? Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 25(10), 3136-8
• WELHAM,, CLARK, and SALTER,, 2009. A novel liver specific isoform of the rat LAR transcript is expressed as a truncated isoform encoded from a 5'UTR located within intron 11. BMC molecular biology. 10(1), 30
• CHAN, SHUN-KAI, RILEY, PAUL, PRICE, KAREN L, MCELDUFF, FIONA, WINYARD, PAUL J D, WELHAM, SIMON J M, WOOLF, ADRIAN S and LONG, DAVID A, 2009. Corticosteroid-induced kidney dysmorphogenesis is associated with deregulated expression of known cystogenic molecules, as well as indian hedgehog. American journal of physiology. Renal physiology. 298(2), F346-56

• View all publications

• LANGLEY-EVANS, SIMON C, DANIEL, ZOE C, WELLS, CATHY A, RYAN, KEVIN J P, PLANT, RICHARD and WELHAM, SIMON J M, 2010. Protein restriction in the pregnant mouse modifies fetal growth and pulmonary development: role of fetal exposure to beta-hydroxybutyrate. Experimental physiology. 96, 203-215
• WELHAM, SIMON J M, 2010. Programmed repression of tubular 11{beta}-HSD2--a novel form of AME? Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 25(10), 3136-8
• WELHAM,, CLARK, and SALTER,, 2009. A novel liver specific isoform of the rat LAR transcript is expressed as a truncated isoform encoded from a 5'UTR located within intron 11. BMC molecular biology. 10(1), 30
• CHAN, SHUN-KAI, RILEY, PAUL, PRICE, KAREN L, MCELDUFF, FIONA, WINYARD, PAUL J D, WELHAM, SIMON J M, WOOLF, ADRIAN S and LONG, DAVID A, 2009. Corticosteroid-induced kidney dysmorphogenesis is associated with deregulated expression of known cystogenic molecules, as well as indian hedgehog. American journal of physiology. Renal physiology. 298(2), F346-56
• BOGDARINA, I., WELHAM, S., KING, P.J, BURNS, S.P. and CLARK, A.J.L., 2007. Epigenetic modification of the renin-angiotensin system in the fetal programming of hypertension. Circulation Research. 100(4), 520-526
• WELHAM, S.J.M., RILEY, P.R., WADE, A., HUBANK, M. and WOOLF, A.S., 2005. Maternal diet programs embryonic kidney gene expression. Physiological Genomics. 22(1), 48-56
• WELHAM, SIMON J and WOOLF, ADRIAN S, 2003. Organ culture of intact metanephric kidneys. Methods in molecular medicine. 86, 169-77
• WELHAM, S.J.M., WADE, A. and WOOLF, A.S., 2002. Protein restriction in pregnancy is associated with increased apoptosis of mesenchymal cells at the start of rat metanephrogenesis. Kidney International. 61(4), 1231-1242
• WOOLF, A.S. and WELHAM, S.J.M., 2002. Cell turnover in normal and abnormal kidney development. Nephrology, Dialysis, Transplantation. 17(Suppl 9), 2-4
• LANGLEY-EVANS, S C, WELHAM, S J and JACKSON, A A, 1999. Fetal exposure to a maternal low protein diet impairs nephrogenesis and promotes hypertension in the rat. Life Sciences. 64(11), 965-74
• LANGLEY-EVANS, S C, SHERMAN, R C, WELHAM, S J, NWAGWU, M O, GARDNER, D S and JACKSON, A A, 1999. Intrauterine programming of hypertension: the role of the renin-angiotensin system. Biochemical Society Transactions. 27(2), 88-93
• LANGLEY-EVANS, S C, GARDNER, D S and WELHAM, S J, 1998. Intrauterine programming of cardiovascular disease by maternal nutritional status. Nutrition. 14(1), 39-47
• LANGLEY-EVANS, S C, WELHAM, S J, SHERMAN, R C and JACKSON, A A, 1996. Weanling rats exposed to maternal low-protein diets during discrete periods of gestation exhibit differing severity of hypertension. Clinical Science. 91(5), 607-15