Stephen Lawrence

Contact

• workBioenergy and Brewing Science Building
  Sutton Bonington Campus
  Sutton Bonington
  Leicestershire
  LE12 5RD
  UK
• work0115 951 6697
• stephen.lawrence@nottingham.ac.uk

Research Summary

Background

Stephen Lawrence was awarded an upper-second class honours degree in Biochemistry and Microbiology at the University of Sheffield in 2002. He then joined Professor Katherine Smart's research group at Oxford Brookes University to start a PhD in Brewing Yeast Systems Biology, completing it at the University of Nottingham. Stephen is currently a post-doctoral research fellow at the University of Nottingham.

Research Interests

Research interests include yeast heterogeneity in the cone of fermentation vessels, formation of brewing yeast mitochondrial DNA (mtDNA) mutants during yeast handling processes and the influence of mitochondrial copy number on susceptibility of brewing yeast mtDNA to damage. He has recently begun in new research project in association with SABMiller.

Recent Publications

• LAWRENCE, SJ and SMART, KA, 2011. The impact of cwp and dan gene-encoded mannoproteins on cell wall thickness under aerobic and anaerobic conditions Journal Of The American Society Of Brewing Chemists. 69(3), 139-143
• GIBSON B, GRAHAM N, BOULTON C, BOX W, LAWRENCE S, LINFORTH R, MAY S, SMART K., 2010. Differential yeast gene transcription during brewery propagation Journal of the American Society of Brewing Chemists. 68(1), 21-29
• GIBSON, B. R, BOULTON, C. A, BOX, W, GRAHAM, N. S, LAWRENCE, S. J and LINFORTH, R. S. T. & SMART, K. A., 2009. Amino acid uptake and yeast gene transcription during Industrial brewery fermentation Journal of the American Society of Brewing Chemists. 67(3), 157-165
• LAWRENCE, S. J., GIBSON, B. R. and SMART, K. A., 2009. Expression of the cell wall mannoprotein genes CWP and DAN during industrial scale fermentation Journal of the American Society of Brewing Chemists. 67(1), 58-62 (In Press.)

• View all publications

Past Research

Expression and functional analysis of brewing yeast cell wall genes during anaerobic fermentation. Investigated changes to the brewing yeast cell wall during the transition from aerobiosis to anaerobiosis. Gene expression and cell wall properties were analysed.

• LAWRENCE, SJ and SMART, KA, 2011. The impact of cwp and dan gene-encoded mannoproteins on cell wall thickness under aerobic and anaerobic conditions Journal Of The American Society Of Brewing Chemists. 69(3), 139-143
• GIBSON B, GRAHAM N, BOULTON C, BOX W, LAWRENCE S, LINFORTH R, MAY S, SMART K., 2010. Differential yeast gene transcription during brewery propagation Journal of the American Society of Brewing Chemists. 68(1), 21-29
• GIBSON, B. R, BOULTON, C. A, BOX, W, GRAHAM, N. S, LAWRENCE, S. J and LINFORTH, R. S. T. & SMART, K. A., 2009. Amino acid uptake and yeast gene transcription during Industrial brewery fermentation Journal of the American Society of Brewing Chemists. 67(3), 157-165
• LAWRENCE, S. J., GIBSON, B. R. and SMART, K. A., 2009. Expression of the cell wall mannoprotein genes CWP and DAN during industrial scale fermentation Journal of the American Society of Brewing Chemists. 67(1), 58-62 (In Press.)
• GIBSON, B., LAWRENCE, S., BOULTON, C., BOX, W., GRAHAM, N., LINFORTH, R. and SMART, K., 2008. The oxidative stress response of a lager brewing yeast strain during industrial propagation and fermentation. FEMS Yeast Research. 8(4), 574-585
• GIBSON, B.R., BOULTON, C.A., BOX, W.G., GRAHAM, N.S., LAWRENCE, S.J., LINFORTH, R.S.T. and SMART, K.A., 2008. Carbohydrate utilization and the lager yeast transcriptome during brewery fermentation Yeast. 25, 549-562
• GIBSON, B, LAWRENCE, S, LECLAIRE, J, POWELL, C and SMART, K, 2007. Yeast responses to stresses associated with industrial brewery handling. FEMS Microbiology Reviews. 31, 535-569
• LAWRENCE, S.J. and SMART, K.A., 2007. Impact of CO2-Induced Anaerobiosis on the Measurement of Flocculation Journal of the American Society of Brewing Chemists. 65(4), 208-213
• MILLER, K.J., GIBSON, B.R., LAWRENCE, S.J., BOULTON, C.A. and SMART, K.A., 2007. Congress; 31st. VOL 31, 52
• SMART, K.A., LAWRENCE, S., LECAIRE, J. and DAVY, S.C., 2006. Brewing Yeast Flocculation: A model For Onset and Control In: Institute of Brewing and Distilling Asia Pacific. CD Edtion
• GIBSON, B. R., LAWRENCE, S. J. and SMART, K. A., 2005. The oxidative stress response of brewing yeast during brewery propagation and fermentation PROCEEDINGS OF THE 30TH EBC CONGRESS -CD-ROM EDITION-. VOL 30, 31
• GIBSON, B.R., LAWRENCE, S. J. and AND SMART, K.A., 2005. The Oxidative Stress Response of Brewing Yeast During Brewery Propagation and Fermentation In: Proceedings of the 30th European Congress. 264-280
• KESZENMAN-PEREYRA, DAVID, LAWRENCE, STEPHEN, TWFIEG, MOHAMMED-E, PRICE, JACQUELINE and TURNER, GEOFFREY, 2003. The npgA/ cfwA gene encodes a putative 4'-phosphopantetheinyl transferase which is essential for penicillin biosynthesis in Aspergillus nidulans. Current Genetics. 43(3), 186-90