Huw Williams

Contact

• workRoom A11 Centre for Biomedical Sciences
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 82 32526
• huw.williams@nottingham.ac.uk
• nottingham.ac.uk/analytical

Recent Publications

• FURSE, SAMUEL, LIDDELL, SUSAN, ORTORI, CATHARINE, WILLIAMS, HUW, NEYLON, D.CAMERON, SCOTT, DAVID, BARRETT, DAVID and GRAY, DAVID, 2013. The lipidome and proteome of oil bodies from Helianthus annuus (common sunflower) J Biological Chemistry. 6(2), 63-76
• KITSON, R.R.A., CHANG, C.-H., XIONG, R., WILLIAMS, H.E.L., DAVIS, A.L., LEWIS, W., DEHN, D.L., SIEGEL, D., ROE, S.M., PRODROMOU, C., ROSS, D. and MOODY, C.J., 2013. Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90 Nature Chemistry. 5(4), 307-314
• FURSE S, LIDDELL S, ORTORI CA, WILLIAMS H, NEYLON DC, SCOTT DJ, BARRETT DA and GRAY DA, 2013. The lipidome and proteome of oil bodies from Helianthus annuus (common sunflower). Journal of chemical biology. 6(2), 63-76
• LINDER, J., GARNER, T.P., WILLIAMS, H.E.L., SEARLE, M.S. and MOODY, C.J., 2011. Telomestatin: formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes Journal of the American Chemical Society. 133(4), 1044-1051

• View all publications

• FURSE, SAMUEL, LIDDELL, SUSAN, ORTORI, CATHARINE, WILLIAMS, HUW, NEYLON, D.CAMERON, SCOTT, DAVID, BARRETT, DAVID and GRAY, DAVID, 2013. The lipidome and proteome of oil bodies from Helianthus annuus (common sunflower) J Biological Chemistry. 6(2), 63-76
• KITSON, R.R.A., CHANG, C.-H., XIONG, R., WILLIAMS, H.E.L., DAVIS, A.L., LEWIS, W., DEHN, D.L., SIEGEL, D., ROE, S.M., PRODROMOU, C., ROSS, D. and MOODY, C.J., 2013. Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90 Nature Chemistry. 5(4), 307-314
• FURSE S, LIDDELL S, ORTORI CA, WILLIAMS H, NEYLON DC, SCOTT DJ, BARRETT DA and GRAY DA, 2013. The lipidome and proteome of oil bodies from Helianthus annuus (common sunflower). Journal of chemical biology. 6(2), 63-76
• LINDER, J., GARNER, T.P., WILLIAMS, H.E.L., SEARLE, M.S. and MOODY, C.J., 2011. Telomestatin: formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes Journal of the American Chemical Society. 133(4), 1044-1051
• GARNER, THOMAS P, WILLIAMS, HUW E L, GLUSZYK, KATARZYNA I, ROE, STEPHEN, OLDHAM, NEIL J, STEVENS, MALCOLM F G, MOSES, JOHN E and SEARLE, MARK S, 2009. Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures. Organic & biomolecular chemistry. 7(20), 4194-200
• TOWNSEND AP, ROTH S, WILLIAMS HEL, STYLIANOU E and THOMAS NR, 2009. New S-adenosyl-L-methionine analogues: synthesis and reactivity studies. Organic letters. 11(14), 2976-9
• BALKWILL GD, GARNER TP, WILLIAMS HEL and SEARLE MS, 2009. Folding topology of a bimolecular DNA quadruplex containing a stable mini-hairpin motif within the diagonal loop. Journal of molecular biology. 385(5), 1600-15
• REA AM, SIMPSON ER, MELDRUM JK, WILLIAMS HEL and SEARLE MS, 2008. Aromatic residues engineered into the beta-turn nucleation site of ubiquitin lead to a complex folding landscape, non-native side-chain interactions, and kinetic traps. Biochemistry. 47(48), 12910-22
• BALKWILL, GRAHAM D, WILLIAMS, HUW E L and SEARLE, MARK S, 2007. Structure and folding dynamics of a DNA hairpin with a stabilising d(GNA) trinucleotide loop: influence of base pair mis-matches and point mutations on conformational equilibria. Organic and Biomolecular Chemistry. 5(5), 832-9
• SEARLE, M. S., WILLIAMS, H. E. L., GALLAGHER, C. T., GRANT, R. J. and STEVENS, M. F. G., 2004. Structure and K^+ ion-dependent stability of a parallel-stranded DNA quadruplex containing a core A-tetrad Organic and Biomolecular Chemistry. VOL 2(NUMB 6), 810-812
• SEARLE MS, WILLIAMS HEL, GALLAGHER CT, GRANT RJ and STEVENS MFG, 2004. Structure and K+ ion-dependent stability of a parallel-stranded DNA quadruplex containing a core A-tetrad. Organic & biomolecular chemistry. 2(6), 810-2
• SEARLE, M. S., MAYNARD, A. J. and WILLIAMS, H. E. L., 2003. DNA recognition by the anthracycline antibiotic respinomycin D: NMR structure of the intercalation complex with d(AGACGTCT)~2 Organic and Biomolecular Chemistry. VOL 1(NUMB 1), 60-66
• COLGRAVE, M. L., WILLIAMS, H. E. L. and SEARLE, M. S., 2002. Structure of a Drug-Induced DNA T-Bulge: Implications for DNA Frameshift Mutations Angewandte Chemie International Edition. VOL 41(PART 24), 4754-4756
• WILLIAMS, H. E. L., COLGRAVE, M. L. and SEARLE, M. S., 2002. Drug recognition of a DNA single strand break. Nogalamycin intercalation between coaxially stacked hairpins European Journal of Biochemistry. VOL 269(PART 6), 1726-1733
• COLGRAVE ML, WILLIAMS HEL and SEARLE MS, 2002. Structure of a drug-induced DNA T-bulge: implications for DNA frameshift mutations. Angewandte Chemie (International ed. in English). 41(24), 4754-6
• WILLIAMS HEL, COLGRAVE ML and SEARLE MS, 2002. Drug recognition of a DNA single strand break: nogalamycin intercalation between coaxially stacked hairpins. European journal of biochemistry / FEBS. 269(6), 1726-33
• COLGRAVE, M. L., WILLIAMS, H. E. L. and SEARLE, M. S., 2001. Binding of anthracycline antibiotic nogalamycin to the site of a DNA single strand break engineered between two co-axially stacked hairpins Chemical Communications. PART 4, 315-316