Colin Scotchford

Contact

• workRoom A33a Coates
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 951 3742
• fax0115 951 3800
• colin.scotchford@nottingham.ac.uk

Expertise Summary

My research interests are in biomaterials, with particular experience in materials for the repair or replacement of bone and cartilage. My research focuses on three specific aspects. These are, investigation of cell-material surface interactions down to the molecular level, application of developing methodologies for the assessment of biocompatibility and the development of novel biomaterials for application in the areas indicated above. These areas have natural overlaps and as such provide a cohesive research structure.

Research Summary

Current research can be grouped under cell-material surface interactions, biocompatibility assessment or the development of novel materials or structures for the repair or replacement of tissues such… read more

Recent Publications

• COLIN A SCOTCHFORD, 2012. Mechanical properties of epidermal cells of whole living roots of Arabidopsis thaliana: an atomic force microscopy study Physical reviews E. (In Press.)
• 2012. Influence of screw holes on properties of phosphate glass fibre reinforced polylactic-acid composite plates Journal of Biomaterials Applications. (In Press.)
• SCOTCHFORD, C A, SHATAHERI, M, CHEN, P-S, EVANS, M, PARSONS, A J, AITCHISON, G A, EFEOGLU, C, BURKE, J L, VIKRAM, A, FISHER, S E and RUDD, C D, 2011. Repair of calvarial defects in rats by prefabricated, degradable, long fibre composite implants. Journal of biomedical materials research. Part A. 96(1), 230-8
• 2011. Effect of compressive plane strain on osteoblast-like cells in vitro International Journal of Artificial Organs. 34(8), 690

• View all publications

Current Research

Current research can be grouped under cell-material surface interactions, biocompatibility assessment or the development of novel materials or structures for the repair or replacement of tissues such as cartilage and bone.

Cell-material surface interactions focuses on the relationship between material surface properties, protein adsorption and cell adhesion and function. There are three strands of current research under this grouping.

The first area draws on the thin film coating expertise in the School of M3, to develop biologically functionalised coatings for specific implant applications. This initiative has attracted industrial sponsorship.

The second area has developed with colleagues in the School of Biomedical Sciences to exploit proteomic methodologies to investigate early molecular level responses of cells to well characterisied material surfaces. The aims of this work are twofold. First to elucidate novel molecular events occurring in cells contacting material surfaces. Second to evaluate the diagnostic/screening potential of such methods in application to specific material/coating selection. This work has also attracted industrial funding. The initial work has identified the association of proteins not previously associated with cell adhesion events with such processes, opening the door to exciting research opportunities.

The third area of activity is a collaboration with colleagues in the Department of Mathematics, working on the development of new models of active cell motion on biomaterial surfaces. This is an exciting cross-disciplinary venture.

My research strategy is to link the more fundamental studies described above to research that is closer to clinical application. The best example of such a programme is the development of a novel degradable composite material for bone repair. This has involved significant biocompatibility assessment input at the centre of the programme for over 10 years.

More recent established material development areas include the development of novel scaffolds for tissue engineering applications, bioactive coatings for bone tissue integration and nanocomposites for bone repair applications.

Future Research

Research topics that are currently either at the stage of conception of initiation include:

The progression of the novel degradable composite for cranio-maxillofacial bone repair indicated under'current reasearch' from laboratory to clinic.

The application of cutting edge electron microscopy preparation methods for high resolution investigation of intact cell-material surface interfaces.

The development of nanocomposite biomaterials and assessment of nanoparticulate biocompatibility

Elaboration of research themes arising from the use of proteomic methodologies for the assessment of cell-material surface interactions

Investigation of the potential for material surface property modification to promote the desired differentiation of mesenchymal stem cells for tissue repair

• COLIN A SCOTCHFORD, 2012. Mechanical properties of epidermal cells of whole living roots of Arabidopsis thaliana: an atomic force microscopy study Physical reviews E. (In Press.)
• 2012. Influence of screw holes on properties of phosphate glass fibre reinforced polylactic-acid composite plates Journal of Biomaterials Applications. (In Press.)
• SCOTCHFORD, C A, SHATAHERI, M, CHEN, P-S, EVANS, M, PARSONS, A J, AITCHISON, G A, EFEOGLU, C, BURKE, J L, VIKRAM, A, FISHER, S E and RUDD, C D, 2011. Repair of calvarial defects in rats by prefabricated, degradable, long fibre composite implants. Journal of biomedical materials research. Part A. 96(1), 230-8
• 2011. Effect of compressive plane strain on osteoblast-like cells in vitro International Journal of Artificial Organs. 34(8), 690
• 2011. Composite PLA scaffolds reinforced with PDO fibres for tissue engineering. Journal of Biomaterials Applications. (In Press.)
• PEGG, E. C., WALKER, G. S., SCOTCHFORD, C. A., FARRAR, D. and GRANT, D., 2009. Mono-functional aminosilanes as primers for peptide functionalization Journal of Biomedical Materials Research Part A. VOL 90(NUMBER 4), 947-958
• NOTARA,, SCOTCHFORD,, GRANT,, WESTON, and ROBERTS,, 2009. Cytocompatibility and hemocompatibility of a novel chitosan-alginate gel system. Journal of Biomedical Materials Research Part A. 89(4), 854-64
• AHMED,, PARSONS,, JONES,, WALKER,, SCOTCHFORD, and RUDD,, 2009. Cytocompatibility and Effect of Increasing MgO Content in a Range of Quaternary Invert Phosphate-Based Glasses. Journal of biomaterials applications.
• EDWARDS, H K, FAY, M W, ANDERSON, S I, SCOTCHFORD, C A, GRANT, D M and BROWN, P D, 2009. An appraisal of ultramicrotomy, FIBSEM and cryogenic FIBSEM techniques for the sectioning of biological cells on titanium substrates for TEM investigation. Journal of microscopy. 234(1), 16-25
• EFEOGLU,, BURKE,, PARSONS,, AITCHISON,, SCOTCHFORD,, RUDD,, VIKRAM, and FISHER,, 2009. Analysis of calvarial bone defects in rats using microcomputed tomography: potential for a novel composite material and a new quantitative measurement. The British journal of oral & maxillofacial surgery.
• BARRY,, EVSEEV,, MARKOV,, UPTON,, SCOTCHFORD,, POPOV, and HOWDLE,, 2008. In vitro study of hydroxyapatite-based photocurable polymer composites prepared by laser stereolithography and supercritical fluid extraction. Acta biomaterialia.
• BALL,, GRANT,, LO, and SCOTCHFORD,, 2008. The effect of different surface morphology and roughness on osteoblast-like cells. Journal of Biomedical Materials Research Part A. 86(3), 637-47
• PEGG,, WALKER,, SCOTCHFORD,, FARRAR, and GRANT,, 2008. Mono-functional aminosilanes as primers for peptide functionalization. Journal of Biomedical Materials Research Part A.
• CLARK, M E, GRANT, D M, WALKER, G S, FARRAR, D F and SCOTCHFORD, C A, 2008. 33. The Development of Nanoparticulate Materials for Biodegradable Bone Fracture Plates: (I) International Journal of Nano- and Biomaterials. 1, 203-221
• WOODRUFF,M, JONES,P, FARRAR,D, GRANT,DM and SCOTCHFORD,CA, 2007. Human osteoblast cell spreading and vinculin expression upon biomaterial surfaces. Journal of molecular histology. 38(5), 491-9
• AHMED, I., PARSONS, A.J., SCOTCHFORD, C.A. and RUDD, C.D., 2007. Fully Resorbable Composites as Bone Regenerative Implant Devices In: FP7 General Information Meeting and EuMAT Brokerage Event.
• BROWN, D M, KINLOCH, I A, BANGERT, U, WINDLE, A H, SCOTCHFORD, D M, WALKER, G S, SCOTCHFORD, C A, DONALDSON, K and STONE, V, 2007. 34. An in vitro study of the potential of carbon nanotubes and nanofibres to induce inflammatory mediators and frustrated phagocytosis Carbon. 45, 1743-1756
• SILVA, M.M.C.G., CYSTER, L.A., BARRY, J.J.A., YANG, X.B., OREFFO, R.O.C., GRANT, D.M., SCOTCHFORD, C.A., HOWDLE, S.M., SHAKESHEFF, K.M. and ROSE, F.R.A.J., 2006. The effect of anisotropic architecture on cell and tissue infiltration into tissue engineering scaffolds Biomaterials. 27(35), 5909-5917
• PEGG, E.C., FARRAR, D., SCOTCHFORD, C. A., WALKER, G.S. and GRANT, D.M., 2006. Organic Modification of Titania Sol-Gels and Surfaces Advances in Science and Technology. 53, 38-43
• OLIVER, J.M., KING, J.R., ENGEL, C., SCOTCHFORD, C.A. and GRANT D.M., 2006. An experimental and theoretical investigation of a symmetry breaking mechanism for cell polarization In: Proc. ASME Summer Bioengineering Conference.
• CLARK, M.E., ENGEL, C., FELSTEAD, P.J.C., WALTER, D.M., FARRAR, D.F., WALKER, G.S., SCOTCHFORD, C. A. and GRANT, D.M., 2006. In vitro Evaluation of Osteoblast and Fibroblast Responses to Precipitated Nano-particulate Calcium Carbonate Advances in Science and Technology. 53, 44-49
• PARSONS AJ, BURLING LD, SCOTCHFORD CA, WALKER GS, RUDD CD., 2006. Properties of sodium-based ternary phosphate glasses produced from readily avaialble phosphate salts Journal of Non-Crystalline Solids. 352(50-51), 5309-5317
• BARRY, JJA, SILVA MMCG, CARTMELL, SH, GULDBERG RE, SCOTCHFORD CA, HOWDLE SM., 2006. Porous Methacrylate tissue engineered scaffolds: using carbon dioxide to control porosity and interconnectivity Journal of Materials Science. 41(13), 4197-4204
• JIANG, G., EVANS, M.E., JONES, I.A., RUDD, C.D., SCOTCHFORD, C.A. and WALKER, G.S., 2005. Preparation of poly(ε-caprolactone)/continuous bioglass fibre composite using monomer transfer moulding for bone implant Biomaterials. 26(15), 2281-2288
• CYSTER, L.A., GRANT, D.M., HOWDLE, S.M., ROSE, F.R.A.J., IRVINE, D.J., FREEMAN, D., SCOTCHFORD, C.A. and SHAKESHEFF, K.M., 2005. The influence of dispersant concentration on the pore morphology of hydroxyapatite ceramics for bone tissue engineering Biomaterials. 26(7), 697-702
• BARRY, J.J.A., NAZHAT, S.N., ROSE, F.R.A.J., HAINSWORTH, A.H., SCOTCHFORD, C.A. and HOWDLE, S.M., 2005. Supercritical carbon dioxide foaming of elastomer/heterocyclic methacrylate blends as scaffolds for tissue engineering Journal of Materials Chemistry. 15(46), 4881-4888
• OLIVER, J.M., KING, J.R., MCKINLAY, K.J., BROWN, P.D., GRANT, D.M., SCOTCHFORD, C.A. and WOOD, J.V., 2005. Thin-film theories for two-phase reactive flow models of active cell motion Mathematical Medicine and Biology. 22(1), 53-98
• BARRY, JJA, NAZHAT, SN, SCOTCHFORD CA, HOWDLE SM., 2005. Supercritical carbon dioxide processing of elastomer/methacrylate blends to create scaffolds for soft-tissue engineering International Journal of Experimental Pathology. 86(3), A41-A41
• PARSONS, A.J., EVANS, M., RUDD, C.D. and SCOTCHFORD, C.A., 2004. Synthesis and degradation of sodium iron phosphate glasses and their <i>in vitro</i> cell response Journal of Biomedical Materials Research. Part A. 71(2), 283-291
• PARSONS, A.J., BURLING, L.D., RUDD, C.D., SCOTCHFORD, C.A. and WALKER, G.S., 2004. The effect of production regime and crucible materials on the thermal properties of sodium phosphate Glasses Produced from Salts Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 71(1), 22-29
• MCKINLAY, K.J., ALLISON, F.J., SCOTCHFORD, C.A., GRANT, D.M., OLIVER, J.M., KING, J.R., WOOD, J.V. and BROWN, P.D., 2004. Comparison of environmental scanning electron microscopy with high vacuum scanning electron microscopy as applied to the assessment of cell morphology Journal of Biomedical Materials Research. Part A. 69A(2), 359-366
• GOUGH, J. E., CHRISTIAN, P., UNSWORTH, J., EVANS, M. P., SCOTCHFORD, C. A. and JONES, I. A., 2004. Controlled Degradation and Macrophage Responses of a Fluoride-Treated Polycaprolactone JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. VOL 69(PART 1), 17-25
• ROSE, F.R., CYSTER, L.A., GRANT, D.M., SCOTCHFORD, C.A., HOWDLE, S.M. and SHAKESHEFF, K.M., 2004. In vitro assessment of cell penetration into porous hydroxyapatite scaffolds with a central aligned channel. Biomaterials. 25(24), 5507-14
• MCKINLAY, K. J., SCOTCHFORD, C. A., GRANT, D. M., OLIVER, J. M., KING, J. R. and BROWN, P. D., 2004. Scanning electron microscopy of biomaterials In: Institute of Physics Conference Series. 87-90
• BARRY, J. J., GIDDA, H. S., SCOTCHFORD, C. A. and HOWDLE, S. M., 2004. Porous methacrylate scaffolds: supercritical fluid fabrication and in vitro chondrocyte responses Biomaterials. VOL 25(NUMBER 17), 3559-3568
• GOUGH, J.E., CHRISTIAN, P., SCOTCHFORD, C.A. and JONES, I.A., 2003. Craniofacial osteoblast responses to polycaprolactone produced using a novel boron polymerisation technique and potassium fluoride post-treatment Biomaterials. 24(27), 4905-4912
• GOUGH, J.E., CHRISTIAN, P., SCOTCHFORD, C.A. and JONES, I.A., 2003. Long-term craniofacial osteoblast culture on a sodium phosphate and a calcium/sodium phosphate glass Journal of Biomedical Materials Research Part A. 66A(2), 233-240
• SCOTCHFORD, C.A., GARLE, M.J., BATCHELOR, J., BRADLEY, J. and GRANT, D.M., 2003. Use of a novel carbon fibre composite material for the femoral stem component of a THR system: in vitro biological assessment Biomaterials. 24(26), 4871-4879
• ANTONOV, E. N., BAGRATASHVILI, V. N., POPOV, V. K., BALL, M. D., GRANT, D. M., HOWDLE, S. M. and SCOTCHFORD, C. A., 2003. Properties of calcium phosphate coatings deposited and modified with lasers Journal of Materials Science. Materials in medicine. VOL 14(NUMBER 2), 151-155
• UNSWORTH, J. M., ROSE, F. R. A. J., WRIGHT, E., SCOTCHFORD, C. A. and SHAKESHEFF, K. M., 2003. Seeding Cells into Needled Felt Scaffolds for Tissue Engineering Applications JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. VOL 66(PART 2), 425-431
• SCOTCHFORD, C.A., BALL, M., WINKELMANN, M., VÖRÖS, J., CSUCS, C., BRUNETTE, D.M., DANUSER, G. and TEXTOR, M., 2003. Chemically patterned, metal-oxide-based surfaces produced by photolithographic techniques for studying protein- and cell-interactions. II: protein adsorption and early cell interactions Biomaterials. 24(7), 1147-1158
• GOUGH, J.E., CHRISTIAN, P., SCOTCHFORD, C.A., RUDD, C.D. and JONES, I.A., 2002. Synthesis, degradation,and <i>in vitro</i> cell responses of sodium phosphate glasses for craniofacial bone repair Journal of Biomedical Materials Research. 59(3), 481-489
• SCOTCHFORD, C.A., GILMORE, C.P., COOPER, E., LEGGETT, G.L. and DOWNES, S., 2002. Protein adsorption and human osteoblast-like cell attachment and growth on alkylthiol on gold self-assembled monolayers Journal of Biomedical Materials Research. Part A. 59(1), 84-99
• MCKINLAY, K.J., OLIVER, J., SCOTCHFORD, C.A., GRANT, D.M., KING, J. and BROWN, P.D., 2002. Environmental SEM study of the morphology of osteoblast-like cells on titanium and stainless steel surfaces In: 17th European Conference on BioMaterials.
• MCKINLAY, K.J., SCOTCHFORD, C.A., GRANT, D.M., OLIVER, J., KING, J.R. and BROWN, P.D., 2002. Environmental SEM study of the morphology of osteoblast-like cells on titanium and stainless steel surfaces In: Trans. 17th Conference of the European Society for Biomaterials.
• MCKINLAY, K.J., OLIVER, J., SCOTCHFORD, C.A., GRANT, D.M., KING, J. and BROWN, P.D., 2002. Environmental SEM study of the morphology of osteoblast-like cells on titanium and stainless steel surfaces In: Proc. 17th European Conference on Biomaterials.
• PARSONS, A.J., BURLING, L.D., RUDD, C.D., WALKER, G.S. and SCOTCHFORD, C.A., 2002. Effect of cations on the properties of phosphate glasses for the reinforcement of degradable biomedical polymers In: Trans. 17th Conference of the European Society for Biomaterials.
• EVANS, M., GOUGH, J.E., CHRISTIAN, P., JONES, A. and SCOTCHFORD, C.A., 2002. In vitro cell responses to degradable phosphate glasses for craniofacial bone repair In: Trans 28th Annual meeting of the Society for Biomaterials.
• SCOTCHFORD, C.A., EVANS, M., HEATH, D., HUTCHEONS, G., DAVIES, M.C. and DOWNES, S., 2002. Cell and protein interactions with novel methacrylate copolymers In: Trans 28th Annual meeting of the Society for Biomaterials.
• BARRY, J.J., SCOTCHFORD, C.A. and HOWDLE, S.M., 2002. Novel methacrylate scaffolds with controllable interconnected porosity for cartilage repair In: Trans. 17th Conference of the European Society for Biomaterials.
• GOUGH, J. E., SCOTCHFORD, C. A. and DOWNES, S., 2002. Cytotoxicity of Glutaraldehyde Crosslinked Collagen/Poly(vinyl alcohol) Films is by the Mechanism of Apoptosis Journal of Biomedical Materials Research. VOL 61(PART 1), 121-130
• SIM, B., CLADERA, J., SCOTCHFORD, C.A. and O'SHEA, P., 2002. Interactions of fibronectin at the osteoblast cell surface: Fluorescence imaging of highly localised interactions In: Trans. 17th Conference of the European Society for Biomaterials.
• ANTONOV, E.N., BAGRATASHVILI, V.N., POPOV, V.K., BALL, M.D., HOWDLE, S.M. and SCOTCHFORD, C.A., 2002. Influence of PLD coating thickness on cell activity In: Trans. 17th Conference of the European Society for Biomaterials.
• BALL, M.D., DOWNES, S., SCOTCHFORD, C.A., ANTONOV, E.N., BAGRATASHVILI, V. N., POPOV, V.K., LO, W.J., GRANT, D.M. and HOWDLE, S.M., 2001. Osteoblast growth on titanium foils coated with hydroxyapatite by pulsed laser ablation Biomaterials. 22(4), 337-347
• LO, W.J., GRANT, D.M., BALL, M.D., WELSH, B.S., HOWDLE, S.M., ANTONOV, E.N., BAGRATASHVILI, V.N. and POPOV, V.K., 2000. Physical, chemical, and biological characterization of pulsed laser depositied and plasma sputtered hydroxyapatite thin films on titanium alloy Journal of Biomedical Materials Research. 50(4), 536-545
• MCFARLAND, C. D., MAYER, S., SCOTCHFORD, C., DALTON, B. A., STEELE, J. G. and DOWNES, S., 1999. Attachment of Cultured Human Bone Cells to Novel Polymers Journal of Biomedical Materials Research. VOL 44(NUMBER 1), 1-11
• SCOTCHFORD, C. A., COOPER, E., LEGGETT, G. J. and DOWNES, S., 1998. Growth of human osteoblast-like cells on alkanethiol on gold self-assembled monolayers: The effect of surface chemistry Journal of Biomedical Materials Research. VOL 41(NUMBER 3), 431-442
• SCOTCHFORD, C. A., SIM, B., DOWNES, S. and BRADEN, M., 1997. Water uptake and protein release characteristics of a new methacrylate-based polymer system Polymer. VOL 38(NUMBER 15), 3869-3874
• SCOTCHFORD, C. A. and ALI, S. Y., 1997. Association of magnesium whitlockite crystals with lipid components of the extracellular matrix in human articular cartilage Osteoarthritis and Cartilage. VOL 5(NUMBER 2), 107-120
• SCOTCHFORD, C.A. and DOWNES, S., 1997. Application of confocal microscopy to the study of bone cell responses to biomaterial surfaces, Proceedings of Microscopy of Biomaterials II Royal Microscopical Society. Proceedings. 32(Iiii), 5
• Composites for bone repair: phosphate glass fibre reinforced PLA with varying fibre architecture.