Dr Le Cheng Foh is an Assistant Professor at the School of Biosciences, Faculty of Science, University of Nottingham Malaysia Campus. He was a Postdoctoral Research Fellow at the School of Pharmacy, Faculty of Science, University of Nottingham Malaysia Campus for three years prior to joining the Faculty as an academic.
He obtained his PhD from the University of Malaya in 2013 for his research study on designing and development of antimicrobial peptides as alternative antimicrobials against Streptococcus pneumoniae. The significance of his works had been recognized in a number of conferences and symposia. In 2013, Dr Le received the Young Investigator Award in the 9th International Symposium on Antimicrobial Agents and Resistance (ISAAR-9) for his research on the design of a series of novel AMPs which successfully cured the mice from lethal pneumocococal infection. Prior to this, he was awarded the BioInnovation Award during the BioMalaysia 2011 and BioMalaysia 2013. He also won a Silver Medal during the University of Malaya Innovation and Creativity Expo 2010.
Drug discovery, antimicrobial peptides, antimicrobial resistance, infectious disease, industrial biotechnology
Dr Le's major interest is grounded on antimicrobial drug discovery, particularly against the clinical pathogens. Currently, he focuses on understanding the fundamental principles governing the… read more
LE, CHENG-FOH, FANG, CHEE-MUN and SEKARAN, SHAMALA DEVI, 2017. Intracellular Targeting Mechanisms by Antimicrobial Peptides. Antimicrobial agents and chemotherapy. 61(4), CHENG-FOH LE, MOHD YASIM MOHD YUSOF, MAHMOOD AMEEN ABDULLA HASSAN, VANNAJAN SANGHIRAN LEE, DIYANA MOHD ISA and SHAMALA DEVI SEKARAN, 2015. In vivo efficacy and molecular docking of designed peptide that exhibits potent antipneumococcal activity and synergises in combination with penicillin Scientific Reports. 5, 11886
LE, CHENG-FOH, GUDIMELLA, RANGANATH, RAZALI, ROZAIMI, MANIKAM, RISHYA and SEKARAN, SHAMALA DEVI, 2016. Transcriptome analysis of Streptococcus pneumoniae treated with the designed antimicrobial peptides, DM3 SCIENTIFIC REPORTS. 6,
Dr Le's major interest is grounded on antimicrobial drug discovery, particularly against the clinical pathogens. Currently, he focuses on understanding the fundamental principles governing the biological activity of antimicrobial peptides towards designing therapeutically-enhanced synthetic peptide analogues to be used as antibiotic candidates. The mechanisms by which these novel peptides exert microbicidal activities and attenuate microbial virulence will be investigated. Apart from this, he is also interested in the discovery of novel antimicrobial compounds from the natural environments.