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Jon Hobman

Associate Professor of Microbiology, Faculty of Science

Contact

  • workRoom B22 Food Sciences
    Sutton Bonington Campus
    Sutton Bonington
    Leicestershire
    LE12 5RD
    UK
  • work0115 951 6166
  • fax0115 951 6142

Biography

Dr Jon Hobman

Associate Professor of Microbiology

Jon's research interests centre on bacterial metal ion homeostasis and resistance, and pathogenic enterobacteria. Current research areas include:

  • Bacterial resistance to antimicrobial metals.
  • Gene regulation of antimicrobial metal resistance genes.
  • Antimicrobial resistance plasmids and co-selection in Gram-negative bacteria.
  • Laboratory and pathogenic Escherichia coli.
  • Molecular methods for studying bacterial gene regulation and expression.
  • Molecular methods for engineering Gram-negative bacteria.

Expertise Summary

  • Molecular microbiology
  • Gene regulation and regulators
  • Transcriptomics

Teaching Summary

  • Degree convenor for the C501 BSc Microbiology degree
  • Module convenor for:

D21BF3 Microbes and you module

D236F5 Rapid Methods in Microbiology module

D236F6 Microbial Fermentation module

Research Summary

  • My research interests are centred on how bacteria respond to different insults, stresses and changes in external environmental conditions- including antimicrobial agents and the co-selection problem. We are addressing how these systems work through studies on gene regulation and control of gene expression.
  • Allied to this is an interest in understanding how old and new antimicrobial treatments kill bacteria, and how bacteria are resistant to them.
  • I am particularly interested in how bacteria respond to different metal-ion stresses. These stresses can be caused by either excessive or insufficient amounts of essential metal ions or by the presence of toxic metal ions in the bacterial cell.
  • Bacteria have evolved metal-ion specific transcriptional regulators which sense intracellular metal-ion levels and switch on genes involved in removing or detoxifying these metals, or switch off genes that import metals. I am particularly interested in understanding how regulators sense the metal-ion or other cognate chemical species within the cell that they sense and how they regulate transcription of genes involved in the cellular response.
  • We are using comparative functional genomics and molecular microbiology techniques (bioinformatics, gene knockout technology, epitope tagging, reporter gene fusions, site directed mutagenesis, transcriptomics, and chIP on chip and chIP-seq) to study gene regulation and to analyse differences in responses to stress between laboratory and pathogenic Escherichia coli strains. As part of this I am involved in technology platform development, working on increasing the resolution and developing new uses for post-genomic technologies.

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Media summary: Bacterial gene expression, antimicrobial metal resistance, Escherichia coli, transcriptomics,

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Selected Publications

Past Research

  • Mercury, zinc, copper, and lead resistance in bacteria
  • MerR family regulators

Future Research

  • Transcriptomics,
  • ChIP-on chip,
  • Pathogenic E. coli,
  • Metals as antimicrobial agents,
  • Metal ion resistance and homeostasis systems.

School of Biosciences

University of Nottingham
Sutton Bonington Campus
Nr Loughborough
LE12 5RD, UK

For all enquiries please visit:
www.nottingham.ac.uk/enquire

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