Dr Reinhard Stöger
Associate Professor in Epigenetics
Reinhard's research interests encompass epigenetic mechanisms of nucleic acid modifications, chromatin, non-coding RNAs, epigenetic inheritance, gene-environment interactions and energy metabolism. Current research projects include:
- Analysing the impact of environmental stressors on honeybee health, combining transcriptomics, metabolomics, and systems biology.
- Epigenetic regulation of Leptin, encoding a key metabolic hormone.
- Mitochondrial DNA metabolism.
Teaching in courses that cover the following topics: epigenetics, developmental biology, respiration, cell signalling, cell cycle, growth factors, endocrinology, evolutionary adaptations.
Research concentrates on identification and characterisation of genomic loci that are responsive to environmental stressors and stimuli such as under/overnutrition, synthetic compounds and hormones.… read more
DERECKA K, BLYTHE MJ, MALLA S, GENEREUX DP, GUFFANTI A, PAVAN P, MOLES A, SNART C, RYDER T, ORTORI CA, BARRETT DA, SCHUSTER E and STÖGER R, 2013. Transient exposure to low levels of insecticide affects metabolic networks of honeybee larvae PLOS ONE. 8(7):e68191.,
STÖGER, REINHARD, 2008. The thrifty epigenotype: an acquired and heritable predisposition for obesity and diabetes? BioEssays. 30(2), 156-66
LAIRD, CHARLES D, PLEASANT, NICOLE D, CLARK, AARON D, SNEEDEN, JESSICA L, HASSAN, K M ANWARUL, MANLEY, NATHAN C, VARY, JAY C, MORGAN, TODD, HANSEN, R SCOTT and STÖGER, REINHARD, 2004. Hairpin-bisulfite PCR: assessing epigenetic methylation patterns on complementary strands of individual DNA molecules. Proceedings of the National Academy of Sciences of the United States of America. 101(1), 204-9
STÖGER, R, KUBICKA, P, LIU, C G, KAFRI, T, RAZIN, A, CEDAR, H and BARLOW, D P, 1993. Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal. Cell. 73(1), 61-71
Research concentrates on identification and characterisation of genomic loci that are responsive to environmental stressors and stimuli such as under/overnutrition, synthetic compounds and hormones. Do the epigenetic marks change? How persistent are this epigenetic changes?
Reinhard heads an international team that recently reported subtle but distinct changes in expression of metabolic genes and lipid composition in honeybee larvae upon exposure to low levels of an insecticide.
The Leptin gene has unusual DNA modification patterns. How are these epigenetic marks established and how do they modulate the expression of this important metabolic hormone?
Research is also underway to explore DNA metabolism of the mitochondrial genome in response to developmental and environmental stimuli.
Reinhard Stöger has long-standing experience and research interest in epigenetic phenomena.
He worked with Denise Barlow at the IMP/Vienna (Austria), to discover and describe an imprinted gene in mammals.
Reinhard worked in London and Seattle, focusing largely on epigenetic mechanisms in human syndromes and diseases. Reinhard identified a new subfamily of chromodomain helicases, contributed to the conception and development of new methods and research tools.
He advanced a hypothesis that provides an explanation for the difficulty of identifying allelic variations associated with non-syndromic obesity and type 2 diabetes.