Hany Elsheikha
Lecturer in Veterinary Parasitology, Faculty of Medicine & Health Sciences
Contact
- workRoom B75 School of Veterinary Medicine and Science
Sutton Bonington
Licestershire
LE12 5RD - work0115 951 6445
- fax0115 95 16440
- hany.elsheikha@nottingham.ac.uk
Biography
Hany Elsheikha joined The University of Nottingham in 2007 where he holds an academic appointment in The School of Veterinary Medicine and Science. Hany acts as a Lecturer and a module convenor for the Principles of Clinical Veterinary Science (Parasitology). He obtained a first class honours degree in Veterinary Sciences (1993) and MSc (1998) in Veterinary Parasitology from Cairo University, Egypt. He worked full time in dairy farm animal practice 1994 - 1995. Hany earned his PhD from Michigan State University, (Department of Large Animal Clinical Science, 2004), entitled - Molecular Epidemiology and Evolution of Sarcocystis neurona-Agent of equine protozoal myeloencephalitis. In 2005 Hany was awarded the American Society for Microbiology (ASM)/National Center for Infectious Diseases (NCID) Postdoctoral Fellowship. He was a Lecturer at the College of Veterinary Medicine, Mansoura University, Egypt from 2005 to 2006. He is a Fellow of the Royal Society of Public Health (UK) and serves on the Editorial Board of five peer-reviewed journals and an Ad hoc Reviewer of several journals and funding agencies.
Expertise Summary
I have responsibility for teaching Veterinary Parasitology in the year 1, 2, and 3 modules which teach the principals, epidemiology, pathogenesis and control of the common parasitic infections of domestic and wild animals.
Research Summary
My research is devoted chiefly, but not entirely to parasite epidemiology and evolution. Within that area, I have been interested in a large number of cyst-forming protozoan parasites (Sarcocystis,… read more
Selected Publications
- ELSHEIKHA, H.M. and ZHAO, X., 2008. Patterns and role of diversifying selection in the evolution of Toxoplasma gondii SAG5 locus. Parasitology Research, 103(1), 201-207.
- ELSHEIKHA, H M, 2008. Congenital toxoplasmosis: priorities for further health promotion action. Public Health, 122(4), 335-53.
- ELSHEIKHA,, 2008. Safer food for pregnant women: Practices and risks. Public Health, 122, 1407-1409.
- ELSHEIKHA, H.M., HUSSEIN, S.H. and RAHBAR, H.M., 2008. Clinico-pathological effects of Schistosoma mansoni infection associated with simultaneous exposure to malathion in Swiss outbred albino mice. Acta Tropica, 108, 11-19.
Current Research
My research is devoted chiefly, but not entirely to parasite epidemiology and evolution. Within that area, I have been interested in a large number of cyst-forming protozoan parasites (Sarcocystis, Besnoitia, Toxoplasma, Eimeria, Neospora, and Cryptosporidium) and carried out both experimental and observational studies with an evolutionary context. Much of my research over the last decade has been carried out in close collaboration with Professor Mansfield at Michigan State University and also with other researchers, post docs and graduate students in the United States, United Kingdom and Egypt.
Plasticity of Neospora Caninum and Bradyzoite-Tachyzopite Switching Induced by Stress: Neosporosis is a parasitic disease caused by the protozoan parasite Neospora caninum. In the last two decades, N. caninum has been widely recognized as one of the most frequently diagnosed cause of infectious abortion, stillbirth, and maternal infertility in cattle and neurological disease in various animal species. Bovine neosporosis is therefore the subject of animal disease control in several countries. To survive in the host, N. caninum has the ability to convert to cystic form with a thick capsule both in vivo and in vitro using a poorly understood pathway, this may partly explains the difficulties in the treatment of this infection. Switching between bradyzoite and tachyzoite stages is the key step in the pathogenesis of N. caninum infection. Despite attempts to investigate this biological phenomenon, it is evidenced today that this switching process is a highly concerted, cooperative multistep process requiring a variety of molecular interactions between parasite, mammalian host cells and environmental factors. Additionally, there is not enough knowledge on the biological, biochemical and biophysical properties of membrane/cyst wall of N. caninum bradyzoite stage and their structure function relationships. This project funded by the RCVS Trust aims to obtain in depth knowledge on the mechanism and factors involved in the transformation between bradyzoite and tachyzoite stages of N. caninum.
Molecular Pathogenesis and Stress Tolerance in Toxoplasma gondii: I have a long-standing interest in clinical and applied research on the protozoan parasite Toxoplasma gondii. I study host-pathogen interactions that occur during the establishment of intracellular infection by T. gondii in response to stress. As the causative agent of toxoplasmosis disease in humans and animals, T. gondii represents an important public health and economic problem worldwide, where at least third of the world population are infected. While recent advances in the field have provided a new paradigm for parasite survival within the host cell, little is known regarding the molecular and cellular events required to shape a tolerant host cell environment for intracellular development and endurance of this pathogen. It is the understanding of these basic processes that will guide our efforts toward effective prevention or control of toxoplasmosis disease.
Link between Toxoplasma gondii and Schizophrenia: Toxoplasma gondii is also known to induce behavioural alterations and neurotransmitter dysfunction in rodents and may exert an effect on human personality and behaviour. Indeed, infection of humans with T. gondii can produce psychotic symptoms similar to those displayed by persons with schizophrenia. Since 1953, 18 of the 19 studies of T. gondii antibodies in persons with schizophrenia and other psychiatric disorders reported a higher incidence of antibodies in the affected persons; in 11 studies the difference was statistically significant. Some medications used to treat schizophrenia inhibit the replication of T. gondii in cell culture. Although evidence showing a relationship between T. gondii infection and schizophrenia continues to accumulate, any causal link remains tantalizing but not fully proven. Establishing the role of infection with T. gondii in the etiopathogenesis of schizophrenia might lead to new interventions for its prevention and treatment. I study the causal link between Toxoplasma gondii infection and schizophrenia, and the host and parasite determinant(s) involved.