Systematic review of the surrogate markers of insulin sensitivity and secretion compared with gold standard markers

Presented by Dr Lucia Vazquez Rocha 

Type 2 diabetes is a lifestyle-related chronic disease and the role of diet in its development is the topic of intense study. Insulin resistance and diminished insulin secretion are key characteristics of the progression to type 2 diabetes and are often used as an outcome in intervention trials aiming to prevent the development of diabetes. While the gold-standard techniques for measuring insulin sensitivity and insulin secretion are well established, they may be perceived as invasive and expensive for use in dietary intervention studies. Thus, surrogate markers have been proposed as alternative markers for insulin sensitivity and secretion. This systematic review aimed to identify markers of insulin sensitivity and secretion in response to dietary intervention and assess their suitability as surrogates for the gold-standard methodology.

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