Dr Le Cheng Foh is an Assistant Professor at the School of Biosciences, Faculty of Science, University of Nottingham Malaysia Campus (UNMC). He was a Postdoctoral Research Fellow at the School of Pharmacy, UNMC for three years prior to joining the Faculty as an academic.
He obtained his PhD from the University of Malaya in 2013 for his research on designing and development of Antimicrobial Peptides (AMPs) as alternative antibiotics against Streptococcus pneumoniae. The significance of his works had been recognised in a number of conferences and symposia. In 2013, Dr Le received the Young Investigator Award in the 9th International Symposium on Antimicrobial Agents and Resistance (ISAAR-9) for his research on the design of a series of novel AMPs which successfully cured the mice from lethal pneumocococal infection. Prior to this, he was awarded the BioInnovation Award during the BioMalaysia 2011 and BioMalaysia 2013. He also won a Silver Medal during the University of Malaya Innovation and Creativity Expo 2010.
Antimicrobial Peptides, Drug Discovery & Design, Bioproduction of AMPs, High Throughput Peptide Biosynthesis, Pneumococcal Vaccine, Pneumococcal Serotype Epidemiology, Antibiotic Resistance
Programme Director, BSc (Hons) Biotechnology
Module convenor for :-
- BIOS1037 Biochemistry: Building Blocks of Life
- BIOS2058 Microbial Biotechnology
- BIOS3062 Environmental Biotechnology
- BIOS4141 Advanced Industrial & Environmental Biotechnology
Teaching contribution a number of biotechnology & microbiology related modules.
Dr Le's major interest is on drug discovery using Antimicrobial Peptides (AMPs). Currently, he focuses on the directed evolution and next-generation discovery of AMPs using microbial host expression… read more
LE, CHENG-FOH, FANG, CHEE-MUN and SEKARAN, SHAMALA DEVI, 2017. Intracellular Targeting Mechanisms by Antimicrobial Peptides. Antimicrobial agents and chemotherapy. 61(4), CHENG-FOH LE, MOHD YASIM MOHD YUSOF, MAHMOOD AMEEN ABDULLA HASSAN, VANNAJAN SANGHIRAN LEE, DIYANA MOHD ISA and SHAMALA DEVI SEKARAN, 2015. In vivo efficacy and molecular docking of designed peptide that exhibits potent antipneumococcal activity and synergises in combination with penicillin Scientific Reports. 5, 11886
LE, CHENG-FOH, GUDIMELLA, RANGANATH, RAZALI, ROZAIMI, MANIKAM, RISHYA and SEKARAN, SHAMALA DEVI, 2016. Transcriptome analysis of Streptococcus pneumoniae treated with the designed antimicrobial peptides, DM3 SCIENTIFIC REPORTS. 6,
Dr Le's major interest is on drug discovery using Antimicrobial Peptides (AMPs). Currently, he focuses on the directed evolution and next-generation discovery of AMPs using microbial host expression systems. The optimised systems will be applied for bioproduction and high-throughput screening and expression of AMP analogues as novel leads. Besides, his research is aligned towards understanding the fundamental principles governing the biological activity of AMPs towards designing therapeutically-enhanced synthetic peptide variants to be used as the novel antimicrobial agents.
He is also working on discovering novel antimicrobial compounds from the natural environments and improving on the qualitative and quantitative aspects of the antimicrobial compounds. A key area of his research interest is pneumococcal vaccination, in particular pneumococcal serotype distribution and antibiotic profiling,