Centre for Cancer Sciences

Andrew Benest

Associate Professor in Cancer Sciences, Faculty of Medicine & Health Sciences



After completing my first degree in Physiology, I stayed on to complete a PhD with Prof David Bates looking at angiogenesis, arteriolargenesis and lymphangiogenesis. I then moved to Heidelberg, Germany with Prof Hellmut Augustin to learn about the endothelial cell itself - and how its phenotype changes during inflammation and angiogenesis. In order to start I family I moved to Leeds where I struggled with GTPase biology in endothelial cells, but was able to contribute to exploring how NK cells regulate endothelial cell phenotypes during inflammation.

This led to my next move to Nottingham, where i have worked on several projects involving endothelial cell biology and sensing the local environment; shear stress, growth factors, and inflammation. This resulted in my research area today of how the local endothelial microenvironment determines transcriptional changes in the endothelial cell and how this regulates its phenotype. I currently have projects involving transcription factors, hypoxia and extracellular matrix composition and in particular how this is important in vascular diseases, inflammation, cancer and eye disease

Expertise Summary

Endothelial cells



Transcription factors

Teaching Summary

I am the Deputy Director and a senior tutor for the BSc/MSci Cancer Sciences degree.

I am convene 3 modules and enjoy teaching across all years of the degree course. I am also lucky enough to teaching 3rd year medic students in their BMedSci course.

Research Summary


Endothelial cell biology

Recent Publications

Centre for Cancer Sciences

The University of Nottingham
Centre for Biomolecular Sciences
Nottingham, NG7 2RD

telephone: +44 (0) 115 823 1546
email: MS-CCS@nottingham.ac.uk