Claire Seedhouse

Contact

• workRoom B209 Biodiscovery Institute
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 8231822
• claire.seedhouse@nottingham.ac.uk

Biography

Dr Claire Seedhouse is an Associate Professor within the Division of Cancer and Stem Cells, in the School of Medicine, at the University of Nottingham

Claire studied for a BSc (Hons) at Bath University which included two industrial placements (1995). She did her PhD at the Paterson Institute for Cancer Research, Manchester where she developed an interest in DNA damage and repair (1999). After completing several post-doctoral research positions and a fellowship at the University of Nottingham she was appointed as the Skillington Haematology Lecturer in 2009. She has published more than 40 papers (h index 24) and receives external, and local, peer-reviewed funding for her research.

Teaching Summary

Course Director MSc Oncology

Lecturer - MSc Oncology, BMed Sciences, BSc/MSci Cancer Sciences

Research Summary

Claire's research focuses on mechanisms of drug action and resistance in haematological malignancies, including acute myeloid leukaemia (AML), multiple myeloma and lymphoma.

Current research projects include:

- Targeting Bcl2 family members in AML and myeloma

- NPM as a therapeutic target in AML

- Targeting dormant cells in leukaemia

- Response of AML and myeloma cells to novel therapeutic drugs

Research is funded by peer-reviewed grants from national and local charities and industrial support. The group is comprised of laboratory scientists and has strong links with clinicians and clinical scientists and has a solid publication track record in high-quality peer-reviewed journals with a number of highly cited (>100 citations) papers.

Selected Publications

• BAILEY, G. D., DOOLAN, L., BASKAR, A., SMITH, L. C. and SEEDHOUSE, C. H., 2020. Preferential transcription of the mutated allele in NPM1 mutated acute myeloid leukaemia SCIENTIFIC REPORTS. 10(1),
• BAILEY, GRAHAM D, QUTOB, HAITHAM M H, AKHTAR, ASMA, RUSSELL, NIGEL H and SEEDHOUSE, CLAIRE H, 2019. DNA damage corrects the aberrant cytoplasmic localisation of nucleophosmin in NPM1 mutated acute myeloid leukaemia. British journal of haematology.
• GRUNDY, MARTIN, BALAKRISHNAN, SAHANA, FOX, MATTHEW, SEEDHOUSE, CLAIRE H and RUSSELL, NIGEL H, 2018. Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells. Oncotarget. 9(102), 37777-37789
• ALHUTHALI, HAYAA MOEED, BRADSHAW, TRACEY D., LIM, KUAN-HON, KAM, TOH-SEOK and SEEDHOUSE, CLAIRE H., 2020. The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun BMC CANCER. 20(1),

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• THOMPSON, JAMIE L., VELASCO, ANGELA DOWNIE RUIZ, CARDALL, ALICE, TARBOX, REBECCA, RICHARDSON, JAINEETA, CLARKE, GEMMA, LISTER, MICHELLE, HOWSON-WELLS, HANNAH C., FLEMING, VICKI M., KHAKH, MANJINDER, SLOAN, TIM, DUCKWORTH, NICHOLA, WALSH, SARAH, DENNING, CHRIS, MCCLURE, C. PATRICK, BENEST, ANDREW V. and SEEDHOUSE, CLAIRE H., 2021. Comparative effects of viral-transport-medium heat inactivation upon downstream SARS-CoV-2 detection in patient samples JOURNAL OF MEDICAL MICROBIOLOGY. 70(3),
• ALMASMOUM, HIBAH ALI, AIRHIHEN, BLESSING, SEEDHOUSE, CLAIRE and WINKLER, GERLOF SEBASTIAAN, 2021. Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma LEUKEMIA & LYMPHOMA. 62(2), 281-290
• ALHUTHALI, HAYAA MOEED, BRADSHAW, TRACEY D., LIM, KUAN-HON, KAM, TOH-SEOK and SEEDHOUSE, CLAIRE H., 2020. The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun BMC CANCER. 20(1),
• BAILEY, G. D., DOOLAN, L., BASKAR, A., SMITH, L. C. and SEEDHOUSE, C. H., 2020. Preferential transcription of the mutated allele in NPM1 mutated acute myeloid leukaemia SCIENTIFIC REPORTS. 10(1),
• BAILEY, GRAHAM D, QUTOB, HAITHAM M H, AKHTAR, ASMA, RUSSELL, NIGEL H and SEEDHOUSE, CLAIRE H, 2019. DNA damage corrects the aberrant cytoplasmic localisation of nucleophosmin in NPM1 mutated acute myeloid leukaemia. British journal of haematology.
• ALMARS, AMANY, CHONDROU, PANAGIOTA S., ONYIDO, EMENIKE K., ALMOZYAN, SHEEMA, SEEDHOUSE, CLAIRE, BABAEI-JADIDI, ROYA and NATERI, ABDOLRAHMAN S., 2019. Increased FLYWCH1 Expression is Negatively Correlated with Wnt/-catenin Target Gene Expression in Acute Myeloid Leukemia Cells INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 20(11),
• GRUNDY M, SEEDHOUSE C, JONES T, ELMI L, HALL M, GRAHAM A, RUSSELL N and PALLIS M, 2018. Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling. PloS one. 13(1), e0190682
• AL-ASADI MG, BRINDLE G, CASTELLANOS M, MAY ST, MILLS KI, RUSSELL NH, SEEDHOUSE CH and PALLIS M, 2018. A molecular signature of dormancy in CD34+CD38- acute myeloid leukaemia cells. Oncotarget. 8(67), 111405-111418
• GRUNDY, MARTIN, BALAKRISHNAN, SAHANA, FOX, MATTHEW, SEEDHOUSE, CLAIRE H and RUSSELL, NIGEL H, 2018. Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells. Oncotarget. 9(102), 37777-37789
• YU, NING, SEEDHOUSE, CLAIRE, RUSSELL, NIGEL and PALLIS, MONICA, 2018. Quantitative assessment of the sensitivity of dormant AML cells to the BAD mimetics ABT-199 and ABT-737 LEUKEMIA & LYMPHOMA. 59(10), 2447-2453
• ALI, REEM, AL-KAWAZ, ABDULBAQI, TOSS, MICHAEL S., GREEN, ANDREW R., MILIGY, ISLAM M., MESQUITA, KATIA A., SEEDHOUSE, CLAIRE, MIRZA, SAMEER, BAND, VIMLA, RAKHA, EMAD A. and MADHUSUDAN, SRINIVASAN, 2018. Targeting PARP1 in XRCC1-Deficient Sporadic Invasive Breast Cancer or Preinvasive Ductal Carcinoma In Situ Induces Synthetic Lethality and Chemoprevention CANCER RESEARCH. 78(24), 6818-6827
• SHAFIEE MN, MONGAN N, SEEDHOUSE C, CHAPMAN C, DEEN S, ABU J and ATIOMO W, 2017. Sterol regulatory element binding protein-1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer. Acta obstetricia et gynecologica Scandinavica. 96(5), 556-562
• SHAFIEE, MOHAMAD NASIR, SEEDHOUSE, CLAIRE, MONGAN, NIGEL, CHAPMAN, CAROLINE, DEEN, SUHA, ABU, JAFARU and ATIOMO, WILLIAM, 2016. Up-regulation of genes involved in the insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link polycystic ovarian syndrome and endometrial cancer MOLECULAR AND CELLULAR ENDOCRINOLOGY. 424(C), 94-101
• PALLIS, M, BURROWS, F, RYAN, J, GRUNDY, M, SEEDHOUSE, C, ABDUL-AZIZ, A, MONTERO, J and LETAI, A, 2016. Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells Oncotarget.
• PALLIS M, BURROWS F, RYAN J, GRUNDY M, SEEDHOUSE C, ABDUL-AZIZ A, MONTERO J, LETAI A and RUSSELL N, 2016. Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells. Oncotarget. 8(10), 16220-16232
• SHAW, B. E., LEE, F., KRISHNAMURTHY, S., BYRNE, J. L., SEEDHOUSE, C., MAYOR, N. P., MALDONADO-TORRES, H., SAUDEMONT, A., MARSH, S. G. E., MADRIGAL, J. A. and RUSSELL, N. H., 2015. Caspase-8 polymorphisms result in reduced Alemtuzumab-induced T-cell apoptosis and worse survival after transplantation BONE MARROW TRANSPLANTATION. 50(2), 237-243
• SHAFIEE, MOHAMAD NASIR, ABD MALIK, DAHLIA, YUNOS, RYIA ILLANI MOHD, ATIOMO, WILLIAM, OMAR, MOHD HASHIM, GHANI, NUR AZURAH ABDUL, HATTA, AHMAD ZAILANI, SEEDHOUSE, CLAIRE, CHAPMAN, CAROLINE and MOKHTAR, NORFILZA MOHD, 2015. The effect of Metformin on endometrial tumor-regulatory genes and systemic metabolic parameters in polycystic ovarian syndrome - a proof-of-concept study GYNECOLOGICAL ENDOCRINOLOGY. 31(4), 286-290
• ALBARAKATI, NADA, ABDEL-FATAH, TAREK M. A., DOHERTY, RACHEL, RUSSELL, ROSLIN, AGARWAL, DEVIKA, MOSELEY, PAUL, PERRY, CHRISTINA, ARORA, ARVIND, ALSUBHI, NOUF, SEEDHOUSE, CLAIRE, RAKHA, EMAD A., GREEN, ANDREW, BALL, GRAHAM, CHAN, STEPHEN, CALDAS, CARLOS, ELLIS, IAN O. and MADHUSUDAN, SRINIVASAN, 2015. Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy MOLECULAR ONCOLOGY. 9(1), 204-217
• SHAFIEE, MOHAMAD NASIR, KHAN, GULAFSHANA, ARIFFIN, RINA, ABU, JAFARU, CHAPMAN, CAROLINE, DEEN, SUHA, NUNNS, DAVID, BARRETT, DAVID A., SEEDHOUSE, CLAIRE and ATIOMO, WILLIAM, 2014. Preventing endometrial cancer risk in polycystic ovarian syndrome (PCOS) women: Could metformin help? GYNECOLOGIC ONCOLOGY. 132(1), 248-253
• SEEDHOUSE, CLAIRE H., MILLS, KEN I., AHLUWALIA, SOPHIE, GRUNDY, MARTIN, SHANG, SHILI, BURNETT, ALAN K., RUSSELL, NIGEL H. and PALLIS, MONICA, 2014. Distinct poor prognostic subgroups of acute myeloid leukaemia, FLT3-ITD and P-glycoprotein-positive, have contrasting levels of FOXO1 LEUKEMIA RESEARCH. 38(1), 131-137
• ABBOTTS, RACHEL, JEWELL, ROSALYN, NSENGIMANA, JEREMIE, MALONEY, DAVID J., SIMEONOV, ANTON, SEEDHOUSE, CLAIRE, ELLIOTT, FAYE, LAYE, JON, WALKER, CHRISTY, JADHAV, AJIT, GRABOWSKA, ANNA, BALL, GRAHAM, PATEL, POULAM M., NEWTON-BISHOP, JULIA, WILSON, DAVID M., III and MADHUSUDAN, SRINIVASAN, 2014. Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy ONCOTARGET. 5(10), 3273-3286
• SULTANA, R., ABDEL-FATAH, T., ABBOTTS, R., HAWKES, C., ALBARAKATI, N., SEEDHOUSE, C., BALL, G., CHAN, S., RAKHA, E.A., ELLIS, I.O. and MADHUSUDAN, S., 2013. Targeting XRCC1 deficiency in breast cancer for personalized therapy Cancer Research. 73(5), 1621-1634
• SULTANA R, ABDEL-FATAH T, PERRY C, MOSELEY P, ALBARAKTI N, MOHAN V, SEEDHOUSE C, CHAN S and MADHUSUDAN S, 2013. Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase Inhibition Is Synthetically Lethal in XRCC1 Deficient Ovarian Cancer Cells. PloS one. 8(2), e57098
• PALLIS M, BURROWS F, WHITTALL A, BODDY N, SEEDHOUSE C and RUSSELL N, 2013. Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells. BMC pharmacology & toxicology. 14(1), 32 (In Press.)
• ABDEL-FATAH, TAREK, SULTANA, REBEKA, ABBOTTS, RACHEL, HAWKES, CLAIRE, SEEDHOUSE, CLAIRE, CHAN, STEPHEN and MADHUSUDAN, SRINIVASAN, 2013. Clinicopathological and functional significance of XRCC1 expression in ovarian cancer INTERNATIONAL JOURNAL OF CANCER. 132(12), 2778-2786
• WANG, QUNWEI, FRANKS, HESTER A., LAX, STEPHANIE J., EL REFAEE, MOHAMED, MALECKA, ANNA, SHAH, SABARIA, SPENDLOVE, IAN, GOUGH, MICHAEL J., SEEDHOUSE, CLAIRE, MADHUSUDAN, SRINIVASAN, PATEL, POULAM M. and JACKSON, ANDREW M., 2013. The Ataxia Telangiectasia Mutated Kinase Pathway Regulates IL-23 Expression by Human Dendritic Cells JOURNAL OF IMMUNOLOGY. 190(7), 3246-3255
• PALLIS, MONICA, BURROWS, FRANCIS, WHITTALL, ABIGAIL, BODDY, NICHOLAS, SEEDHOUSE, CLAIRE and RUSSELL, NIGEL, 2013. Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells BMC PHARMACOLOGY & TOXICOLOGY. 14,
• SULTANA, R., MCNEILL, D.R., ABBOTTS, R., MOHAMMED, M.Z., ZDZIENICKA, M.Z., QUTOB, H., SEEDHOUSE, C., LAUGHTON, C.A., FISCHER, P.M., PATEL, P.M., WILSON, D.M. and MADHUSUDAN, S., 2012. Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors International Journal of Cancer. 131(10), 2433-2444
• PALLIS M, ABDUL-AZIZ A, BURROWS F, SEEDHOUSE C, GRUNDY M and RUSSELL N, 2012. The multi-kinase inhibitor TG02 overcomes signalling activation by survival factors to deplete MCL1 and XIAP and induce cell death in primary acute myeloid leukaemia cells. British journal of haematology. 159(2), 191-203
• JAWAD M, YU N, SEEDHOUSE C, TANDON K, RUSSELL NH and PALLIS M, 2012. Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in acute Myeloid Leukaemia. BMC cancer. 12, 431
• GRUNDY M, SEEDHOUSE C, RUSSELL NH and PALLIS M, 2011. P-Glycoprotein And Breast Cancer Resistance Protein In Acute Myeloid Leukaemia Cells Treated With The Aurora-B Kinase Inhibitor Barasertib-Hqpa. Bmc Cancer. 11, 254
• JAWAD, M., SEEDHOUSE, C., MONY, U., GRUNDY, M., RUSSELL, N.H. and PALLIS, M., 2010. Analysis of factors that affect in vitro chemosensitivity of leukaemic stem and progenitor cells to gemtuzumab ozogamicin (Mylotarg) in acute myeloid leukaemia Leukemia. 24(1), 74-80
• GRUNDY, M., SEEDHOUSE, C., SHANG, S., RICHARDSON, J., RUSSELL, N. and PALLIS, M., 2010. The FLT3 internal tandem duplication mutation is a secondary target of the aurora B kinase inhibitor AZD1152-HQPA in acute myelogenous leukemia cells Molecular Cancer Therapeutics. 9(3), 661-672
• SEEDHOUSE, C., GRUNDY, M., SHANG, S., RONAN, J., PIMBLETT, H., RUSSELL, N. and PALLIS, M., 2009. Impaired S-phase arrest in acute myeloid leukemia cells with a FLT3 internal tandem duplication treated with clofarabine Clinical Cancer Research. 15(23), 7291-7298
• SEEDHOUSE, C.H., PALLIS, M., GRUNDY, M., SHANG, S. and RUSSELL, N.H., 2009. FLT3-ITD expression levels and their effect on STAT5 in AML with and without NPM mutations British Journal of Haematology. 147(5), 653-661
• MONY, U., JAWAD, M., SEEDHOUSE, C., RUSSELL, N. and PALLIS, M., 2008. Resistance to FLT3 inhibition in an in vitro model of primary AML cells with a stem cell phenotype in a defined microenvironment Leukemia. 22(7), 1395-1401
• SEEDHOUSE,, GRUNDY,, WHITE,, LI,, FISHER,, YAKUNINA,, MOORMAN,, HOY,, RUSSELL,, BURNETT, and PALLIS,, 2007. Sequential Influences of Leukemia-Specific and Genetic Factors on P-Glycoprotein Expression in Blasts from 817 Patients Entered into the National Cancer Research Network Acute Myeloid Leukemia 14 and 15 Trials. Clinical Cancer Research. 13(23), 7059-7066
• CONNELLY-SMITH,, PATTINSON,, GRUNDY,, SHANG,, SEEDHOUSE,, RUSSELL, and PALLIS,, 2007. P-glycoprotein is downregulated in KG1a-primitive leukemia cells by LDL cholesterol deprivation and by HMG-CoA reductase inhibitors. Experimental Hematology.
• SHANG,, SEEDHOUSE,, RUSSELL, and PALLIS,, 2007. Low dose rapamycin does not modulate p-glycoprotein function in acute myeloid leukaemia. Leukemia Research.
• SEEDHOUSE, CLAIRE and RUSSELL, NIGEL, 2007. Advances in the understanding of susceptibility to treatment-related acute myeloid leukaemia. British Journal of Haematology. 137(6), 513-29
• SEEDHOUSE, C.H, HUNTER, H.M., LLOYD-LEWIS, B., MASSIP, A-M., PALLIS, M., CARTER, G.I., GRUNDY, M., SHANG, S. and RUSSELL, N.H., 2006. DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412 Leukemia. 20(12), 2130-2136
• JAWAD, M., SEEDHOUSE, C.H., RUSSELL, N. and PLUMB, M., 2006. Polymorphisms in human homeobox HLX1 and DNA repair RAD51 genes increase the risk of therapy-related acute myeloid leukemia Blood. 108(12), 3916-3918
• BRADBURY, D., CLARKE, D., SEEDHOUSE, C., CORBETT, L., STOCKS, J. and KNOX, A., 2005. Vascular endothelial growth factor induction by prostaglandin E₂ in human airway smooth muscle cells is mediated by E prostanoid EP₂/EP₄ receptors and SP-1 transcription factor binding sites Journal of Biological Chemistry. 280(34), 29993-30000
• FERN, L., PALLIS, M., CARTER, G.I., SEEDHOUSE, C., RUSSELL, N. and BYRNE, J., 2004. Clonal haemopoiesis may occur after conventional chemotherapy and is associated with accelerated telomere shortening and defects in the NQO1 pathway; possible mechanisms leading to an increased risk of t-AML/MDS. British Journal of Haematology. 126(1), 63-71
• SEEDHOUSE, C., FAULKNER, R., ASHRAF, N., DAS-GUPTA, E. and RUSSELL, N., 2004. Polymorphisms in Genes Involved in Homologous Recombination Repair Interact to Increase the Risk of Developing Acute Myeloid Leukemia Clinical Cancer Research. 10(8), 2675-2680
• FAULKNER, R. D., SEEDHOUSE, C. H., DAS-GUPTA, E. P. and RUSSELL, N. H., 2004. BAT-25 and BAT-26, two mononucleotide microsatellites, are not sensitive markers of microsatellite instability in acute myeloid leukaemia British Journal of Haematology. VOL 124(NUMBER 2), 160-165
• HUNTER, H. M., PALLIS, M., SEEDHOUSE, C. H., GRUNDY, M., GRAY, C. and RUSSELL, N. H., 2004. The expression of P-glycoprotein in AML cells with FLT3 internal tandem duplications is associated with reduced apoptosis in response to FLT3 inhibitors British Journal of Haematology. VOL 127(NUMBER 1), 26-33
• SEEDHOUSE, C. H., DAS-GUPTA, E. P. and RUSSELL, N. H., 2003. Methylation of the hMLH1 promoter and its association with microsatellite instability in acute myeloid leukemia Leukemia. 17(1), 83-88
• PALLIS, M., SEEDHOUSE, C., GRUNDY, M. and RUSSELL, N., 2003. Flow cytometric measurement of phosphorylated STAT5 in AML: lack of specific association with FLT3 internal tandem duplications Leukemia Research. VOL 27(NUMBER 9), 803-805
• PALLIS, M., TURZANSKI, J., GRUNDY, M., SEEDHOUSE, C. and RUSSELL, N., 2003. Resistance to spontaneous apoptosis in acute myeloid leukaemia blasts is associated with p-glycoprotein expression and function, but not with the presence of FLT3 internal tandem duplications British Journal of Haematology. VOL 120(PART 6), 1009-1016
• SEEDHOUSE, C., BAINTON, R., LEWIS, M., HARDING, A., RUSSELL, N. and DAS-GUPTA, E., 2002. The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia Blood. 100(10), 3761-3766
• DAS-GUPTA, E. P., SEEDHOUSE, C. H. and RUSSELL, N. H., 2001. Microsatellite instability occurs in defined subsets of patients with acute myeloblastic leukaemia British Journal of Haematology. VOL 114(PART 2), 307-312
• SEEDHOUSE, C H, MARGISON, G P, HENDRY, J H, HAJEER, A and EMBLETON, M J, 2001. Anti-8-oxo-2'-deoxyguanosine phage antibodies: isolation, characterization, and relationship to disease states. Biochemical and biophysical research communications. 280(3), 595-604
• DAS-GUPTA EP, SEEDHOUSE CH and RUSSELL NH, 2000. Dna Repair Mechanisms And Acute Myeloblastic Leukemia. Hematological Oncology. 18(3), 99-110