GRIFFITHS, R. C., SMITH, F. R., LONG, J. E., SCOTT, D., WILLIAMS, H. E. L., OLDHAM, N. J., LAYFIELD, R. and MITCHELL, N. J., 2022. Site-Selective Installation of N-Epsilon-Modified Sidechains into Peptide and Protein Scaffolds via Visible-Light-Mediated Desulfurative C-C Bond Formation ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 61, e202110223 BRENNAN, ANDREW, LAYFIELD, ROBERT, LONG, JED, WILLIAMS, HUW E L, OLDHAM, NEIL J, SCOTT, DANIEL and SEARLE, MARK S, 2022. An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteins. The Journal of biological chemistry. 298(2), 101514
FOSTER, A. D., FLYNN, L. L., CLUNING, C., CHENG, F., DAVIDSON, J. M., LEE, A., POLAIN, N., MEJZINI, R., FARRAWELL, N., YERBURY, J. J., LAYFIELD, R., AKKARI, P. A. and REA, S. L., 2021. p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death SCIENTIFIC REPORTS. 11(1), WATSON, MORAG E., SCOTT, DANIEL, JAMIESON, CRAIG, LAYFIELD, ROBERT and MASON, ANDREW M., 2021. Design, synthesis and evaluation of E2-25K derived stapled peptides PEPTIDE SCIENCE. 113(1), GRIFFITHS, RHYS C., SMITH, FRANCES R., LONG, JED E., WILLIAMS, HUW E. L., LAYFIELD, ROBERT and MITCHELL, NICHOLAS J., 2020. Site-Selective Modification of Peptides and Proteins via Interception of Free-Radical-Mediated Dechalcogenation ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 59(52), 23659-23667 FOSTER, A. D., DOWNING, P., FIGREDO, E., POLAIN, N., STOTT, A., LAYFIELD, R. and REA, S. L., 2020. ALS-associated TBK1 variant p.G175S is defective in phosphorylation of p62 and impacts TBK1-mediated signalling and TDP-43 autophagic degradation MOLECULAR AND CELLULAR NEUROSCIENCE. 108, FOGGIN, SOPHIE, MESQUITA-RIBEIRO, RAQUEL, DAJAS-BAILADOR, FEDERICO and LAYFIELD, ROB, 2019. Biological Significance of microRNA Biomarkers in ALS-Innocent Bystanders or Disease Culprits? FRONTIERS IN NEUROLOGY. 10, SHAW, BARRY, BURRELL, CARLA L., GREEN, DARRELL, NAVARRO-MARTINEZ, ANA, SCOTT, DANIEL, DAROSZEWSKA, ANNA, VAN 'T HOF, ROB, SMITH, LYNN, HARGRAVE, FRANK, MISTRY, SHARAD, BOTTRILL, ANDREW, KESSLER, BENEDIKT M., FISCHER, ROMAN, SINGH, ARCHANA, DALMAY, TAMAS, FRASER, WILLIAM D., HENNEBERGER, KIRSTIN, KING, TURI, GONZALEZ, SILVIA and LAYFIELD, ROBERT, 2019. Molecular insights into an ancient form of Paget's disease of bone PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 116(21), 10463-10472 DUCKER, CHARLES, CHOW, LEO KAM YUEN, SAXTON, JANICE, HANDWERGER, JURGEN, MCGREGOR, ALEXANDER, STRAHL, THOMAS, LAYFIELD, ROBERT and SHAW, PETER E, 2019. De-ubiquitination of ELK-1 by USP17 potentiates mitogenic gene expression and cell proliferation. NUCLEIC ACIDS RESEARCH. 47(9), 4495-4508 RALSTON, STUART H., CORRAL-GUDINO, LUIS, COOPER, CYRUS, FRANCIS, ROGER M., FRASER, WILLIAM D., GENNARI, LUIGI, GUANABENS, NURIA, JAVAID, M. KASSIM, LAYFIELD, ROBERT, O'NEILL, TERENCE W., RUSSELL, ROBERT GRAHAM G., STONE, MICHAEL D., SIMPSON, KEITH, WILKINSON, DIANA, WILLS, RUTH, ZILLIKENS, M. CAROLA and TUCK, STEPHEN P., 2019. Clinical Guidelines on Paget's Disease of Bone JOURNAL OF BONE AND MINERAL RESEARCH. 34(12), 2327-2329 SERVANTE, JULIETTE, ESTRANERO, JASPER, MEIJER, LISETHE, LAYFIELD, ROB and GRUNDY, RICHARD, 2018. Chemical modulation of autophagy as an adjunct to chemotherapy in childhood and adolescent brain tumors. Oncotarget. 9(81), 35266-35277
PAUL TUCK S, LAYFIELD R, WALKER J, MEKKAYIL B and FRANCIS R, 2017. Adult Paget's disease of bone: a review. Rheumatology. (In Press.)
HAQUE F, VARLET P, PUNTONET J, STORER L, BOUNTALI A, RAHMAN R, GRILL J, CARCABOSO AM, JONES C, LAYFIELD R and GRUNDY RG, 2017. Evaluation of a novel antibody to define histone 3.3 G34R mutant brain tumours. Acta neuropathologica communications. 5(1), 45 THOMAS B, MCINTOSH D, FILDES T, ISLAM M, THOMPSON T, LAYFIELD R, SCOTT D, SHAW B, BURRELL CL, GONZALEZ S and TAYLOR S, 2017. Second-Harmonic Generation Imaging of Collagen in Ancient Bone Bone Reports. (In Press.)
SCOTT D, GARNER TP, LONG J, STRACHAN J, MISTRY SC, BOTTRILL AR, TOOTH DJ, SEARLE MS, OLDHAM NJ and LAYFIELD R, 2016. Mass spectrometry insights into a tandem
ubiquitin-binding domain hybrid engineered for the selective recognition of
unanchored polyubiquitin. Proteomics. 16(14), 1961-9 ZEROVNIK E, JERALA NK and LAYFIELD R, 2016. Recent developments in treating Alzheimer’s disease. J Alzheimers Dis Parkinsonism. 5, 220 GOODE A, BUTLER K, LONG J, CAVEY J, SCOTT D, SHAW B, SOLLENBERGER J, GELL C, JOHANSEN T, OLDHAM NJ, SEARLE MS and LAYFIELD R, 2016. Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD. Autophagy. 12(7), 1094-104 SCOTT D, STRACHAN J, KRISHNA VG, SHAW B, TOOTH DJ, SEARLE MS, OLDHAM NJ and LAYFIELD R, 2016. Method for the Purification of Endogenous Unanchored Polyubiquitin Chains. Methods in Molecular Biology. 1449, 203-13 GOODE A, REA S, SULTANA M, SHAW B, SEARLE MS and LAYFIELD R, 2016. ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling. Molecular and Cellular Neurosciences. 76, 52-58 MANZI L, BARROW AS, SCOTT D, LAYFIELD R, WRIGHT TG, MOSES JE and OLDHAM NJ, 2016. Carbene footprinting accurately maps binding sites in protein-ligand and protein-protein interactions. Nature Communications. 7, 13288 MAJCHER V, GOODE A, JAMES V and LAYFIELD R, 2015. Autophagy receptor defects and ALS-FTLD. Molecular and Cellular Neuroscience. 66, 43-52 SCOTT, DANIEL, OLDHAM, NEIL J., STRACHAN, JO, SEARLE, MARK S. and LAYFIELD, ROBERT, 2015. Ubiquitin-binding domains: Mechanisms of ubiquitin recognition and use as tools to investigate ubiquitin-modified proteomes PROTEOMICS. 15(5-6), 844-861 SHAPIRO IM, LAYFIELD R*, LOTZ M*, SETTEMBRE C* and WHITEHOUSE C*, 2014. Boning up on autophagy: the role of autophagy in skeletal biology. Autophagy. 10(1), 7-19 REA S, MAJCHER V, SEARLE MS and LAYFIELD R, 2014. SQSTM1 mutations - bridging Paget disease of bone and ALS/FTLD. Experimental Cell Research. 325, 27-37 GOODE A, LONG JE, SHAW B, RALSTON SH, VISCONTI MR, GIANFRANCESCO F, ESPOSITO T, GENNARI L, MERLOTTI D, RENDINA D, REA SL, SULTANA M, SEARLE MS and LAYFIELD R, 2014. Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function. BBA - Molecular Basis of Disease. 1842, 992-1000 WRIGHT T, REA S, GOODE A, BENNETT AJ, RATAJCZAK T, LONG JE, SEARLE MS, GOLDRING CE, PARK BK, COPPLE IM and LAYFIELD R, 2013. The S349T mutation of SQSTM1 links Keap1/Nrf2 signaling to Paget's disease of bone. Bone. 52, 699-706 SOKRATOUS K, LAYFIELD R and OLDHAM NJ, 2013. The effects of cation adduction upon the conformation of three-helix bundle protein domains. International Journal for Ion Mobility Spectrometry. 16, 19-27
TOOTH, D., GARSED, K., SINGH, G., MARCIANI, L., LAM, C., FORDHAM, I., FIELDS, A., BANWAIT, R., LINGAYA, M., LAYFIELD, R., HASTINGS, M., WHORWELL, P. and SPILLER, R., 2013. Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea:origin and effect of gut transit Gut. n/a(n/a), n/a STRACHAN J, SHAW B, GOPALA KRISHNA V, SCOTT D, DEL POZO JC, HILL K, GAUTAM M, SKOWYRA D, JACOBSON AD, LIU CW, OLDHAM N and LAYFIELD R, 2013. Broad utility of an affinity-enrichment strategy for unanchored polyubiquitin chains Journal of Proteomics & Bioinformatics. S7, 1-7
GIANFRANCESCO F, RENDINA D, DI STEFANO M, MINGIONE A, ESPOSITO T, MERLOTTI D, GALLONE S, MAGLIOCCA S, GOODE A, FORMICOLA D, MORELLO G, LAYFIELD R, FRATTINI A, DE FILIPPO G, NUTI R, SEARLE M, STRAZZULLO P, ISAIA G, MOSSETTI G and GENNARI L, 2012. A non-synonymous TNFRSFIIA variation increases NF-kB activity and the severity of Paget's disease. Journal of Bone and Mineral Research. 27, 443-452 SEARLE MS, GARNER TP, STRACHAN J, LONG J, ADLINGTON J, CAVEY JR, SHAW B and LAYFIELD R, 2012. Structural insights into specificity and diversity in mechanisms of ubiquitin recognition by ubiquitin-binding domains. Biochem Soc Transactions. 40(2), 404-408 SOKRATOUS, K., ROACH, L.V., CHANNING, D., STRACHAN, J., LONG, J., SEARLE, M.S., LAYFIELD, R. and OLDHAM, N.J., 2012. Probing affinity and ubiquitin linkage selectivity of ubiquitin-binding domains using mass spectrometry Journal of the American Chemical Society. 134(14), 6416-6424 RALSTON SH and LAYFIELD R, 2012. Pathogenesis of Paget Disease of Bone. Calcified Tissue International. 91(2), 97-113 TOOTH DJ, KRISHNA VG and LAYFIELD R, 2012. An economical high-throughput protocol for multi-dimensional fractionation of proteins. International Journal of Proteomics. 2012, 735132 SOKRATOUS K, STRACHAN J, ROACH LV, LAYFIELD R and OLDHAM NJ, 2012. Cyclisation of Lys48-linked diubiquitin in vitro and in vivo. FEBS Letters. 586, 4144-4147 GALAZIS, N., OLALEYE, O., HAOULA, Z., LAYFIELD, R. and ATIOMO, W., 2012. Proteomic biomarkers for ovarian cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration Fertility and Sterility. 98(6), 1590-1601.e1 STRACHAN, J., ROACH, L., SOKRATOUS, K., TOOTH, D., LONG, J., GARNER, T.P., SEARLE, M.S., OLDHAM, N.J. and LAYFIELD, R., 2012. Insights into the molecular composition of endogenous unanchored polyubiquitin chains Journal of Proteome Research. 11(3), 1969-1980 DAROSZEWSKA A, VAN 'T HOF RJ, ROJAS JA, LAYFIELD R, LANDAO-BASONGA E, ROSE L, ROSE K, RALSTON SH, 2011. A point mutation in the ubiquitin-associated domain of SQSTM1 is sufficient to cause a Paget's disease-like disorder in mice. Human Molecular Genetics. 20(14), 2734-44 GARNER, T.P., STRACHAN, J., SHEDDEN, E.C., LONG, J.E., CAVEY, J.R., SHAW, B., LAYFIELD, R. and SEARL, M.S., 2011. Independent interactions of ubiquitin-binding domains in a ubiquitin-mediated ternary complex. Biochemistry. 50(42), 9076-9087 BOH BK, NG MY, LECK YC, SHAW B, LONG J, SUN GW, GAN YH, SEARLE MS, LAYFIELD R and HAGEN T, 2011. Inhibition of cullin ring ligases by cycle inhibiting factor: evidence for interference with Nedd8-induced conformational control. Journal of Molecular Biology. 413(2), 430-7 HEINEN C, GARNER TP, LONG J, BÖTTCHER C, RALSTON SH, CAVEY JR, SEARLE MS, LAYFIELD R, DANTUMA NP, 2010. Mutant p62/SQSTM1 UBA domains linked to Paget's disease of bone differ in their abilities to function as stabilization signals. FEBS Letters. 584(8), 1585-90 CERU S, LAYFIELD R, ZAVAŠNIK-BERGANT T, REPNIK U, KOPITAR-JERALA N, TURK V, ZEROVNIK E, 2010. Intracellular aggregation of human stefin B; confocal and electron microscopy study. Biology of the Cell. 102(6), 319-34. ROGERS N, PAINE S, BEDFORD L, LAYFIELD R, 2010. The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration. Neuropathology and Applied Neurobiology. 36, 113-24. LONG, J., GARNER, T.P., PANDYA, M.J., CRAVEN, C.J., CHEN, P., SHAW, B., WILLIAMSON, M.P., LAYFIELD, R. and SEARLE, M.S., 2010. Dimerisation of the UBA domain of p62 inhibits ubiquitin binding and regulates NF-κB signalling Journal of Molecular Biology. 396(1), 178-194 COPPLE, IM, LISTER, A, OBENG, AD, KITTERINGHAM, NR, JENKINS, RE, LAYFIELD, R, FOSTER, BJ, GOLDRING, CE, PARK, BK, 2010. Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defence pathway. Journal of Biological Chemistry. 285, 16782-88 PAINE, S, BEDFORD, L, THORPE, JR, MAYER, RJ, CAVEY, JR, BAJAJ, N, SHEPPARD, PW, LOWE, J, LAYFIELD, R, 2009. Immunoreactivity to Lys63-linked polyubiquitin is a feature of neurodegeneration. Neuroscience Letters. 460(3), 205-8 MURTON, A.J., ALAMDARI, N., GARDINER, S.M., CONSTANTIN-TEODOSIU, D., LAYFIELD, R., BENNETT, T. and GREENHAFF, P.L., 2009. Effects of endotoxaemia on protein metabolism in rat fast-twitch skeletal muscle and myocardium. PLoS One. 4(9), e6945 CHUTHAPISITH, S, BEAN, B, COWLEY, G, EREMIN, JM, SAMPHAO, S, LAYFIELD, R, KERR, ID, WISEMAN, J, EL-SHEEMY, M, SREENIVASAN, T, EREMIN, O, 2009. Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy. European Journal of Cancer. 45(7), 1274-81 ATIOMO, W., KHALID, S., PARAMESHWERAN, S., HOUDA, M. and LAYFIELD, R., 2009. Proteomic biomarkers for the diagnosis and risk stratification of polycystic ovary syndrome: a systematic review BJOG: an International Journal of Obstetrics & Gynecology. 116(2), 137-143 REA, SL,WALSH, JP, WARD, L, MAGNO, AL, WARD, BK, SHAW, B, LAYFIELD, R, KENT, GN, XU, J, RATAJCZAK, T, 2009. Sequestosome 1 Mutations in Paget's Disease of Bone in Australia: Prevalence, Genotype/Phenotype Correlation and a Novel Non-UBA Domain Mutation (P364S) Associated with Increased NF-kappaB Signaling Without Loss of Ubiquitin-Binding. Journal of Bone and Mineral Research. 24(7), 1216-23 NAJAT, D., GARNER, T., HAGEN, T., SHAW, B., SHEPPARD, P.W., FALCHETTI, A., MARINI, F., BRANDI, M.L., LONG, J.E., CAVEY, J.R., SEARLE, M.S. and LAYFIELD, R., 2009. Characterization of a non-UBA domain missense mutation of sequestosome 1 (SQSTM1) in Paget's disease of bone Journal of Bone and Mineral Research. 24(4), 632-642 ATIOMO, WU, KHALID, S, ZIAUDDIN, A, TOOTH, D, LAYFIELD, R, 2009. Framework for a systems approach to proteomic biomarker profiling in polycystic ovary syndrome. Expert Review of Proteomics. 6(5), 469-99 RUTLAND, C., WARNER, L., THORPE, A., ALIBHAI, A., ROBINSON, T., SHAW, B., LAYFIELD, R., BROOK, J.D. and LOUGHNA, S., 2009. Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis Journal of Anatomy. 214(6), 905-915 BEDFORD, L., HAY, D., DEVOY, A., PAINE, S., POWE, D.G., SETH, R., GRAY, T., TOPHAM, I., FONE, K., REZVANI, N., MEE, M., SOANE, T., LAYFIELD, R., SHEPPARD, P.W., EBENDAL, T., USOSKIN, D., LOWE, J. and MAYER, R.J., 2008. Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies Journal of Neuroscience. 28(33), 8189-8198 ALAMDARI, N., CONSTANTIN-TEODOSIU, D., MURTON, A.J., GARDINER, S.M., BENNETT, T., LAYFIELD, R. and GREENHAFF, P.L., 2008. Temporal changes in the involvement of pyruvate dehydrogenase complex in muscle lactate accumulation during lipopolysaccharide infusion in rats Journal of Physiology. 586(6), 1767-1775 GREENHAFF, P.L., KARAGOUNIS, L.G., PIERCE, N,, SIMPSON, E.J., HAZELL, M., LAYFIELD, R., WACKERHAGE, H., SMITH, K., ATHERTON, P., SELBY, A. and RENNIE, M.J., 2008. Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle American Journal of Physiology: Endocrinology and Metabolism. 295(3), E595-E604 LONG, J., GALLAGHER, T.R.A., CAVEY, J.R., SHEPPARD, P.W., RALSTON, S.H., LAYFIELD, R. and SEARLE, M.S., 2008. Ubiquitin recognition by the ubiquitin-associated domain of p62 involves a novel conformational switch Journal of Biological Chemistry. 283(9), 5427-5440 LAYFIELD, R, SEARLE, MS, 2008. Disruption of ubiquitin-mediated processes in diseases of the brain and bone. Biochemical Society Transactions. 36(Pt 3), 469-71 LAYFIELD R, MAYER RJ, 2008. The ubiquitin proteasome system in human disease. Biochimica et Biophysica Acta. 1782(12), 681-2 CANEDA-FERRÓN, B, DE GIROLAMO, LA, COSTA, T, BECK, KE, LAYFIELD, R, BILLETT, EE, 2008. Assessment of the direct and indirect effects of MPP+ and dopamine on the human proteasome: implications for Parkinson's disease aetiology. Journal of Neurochemistry. 105(1), 225-38 GREENHAFF, P. L., KARAGOUNIS, L. G., PEIRCE, N., SIMPSON, E. J., HAZELL, M., LAYFIELD, R., WACKERHAGE, H., SMITH, K., ATHERTON, P., SELBY, A. and RENNIE, M. J., 2008. Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 295(3), E595-E604 ROLLAND, P., MADJD, Z., DURRANT, L., ELLIS, I.O., LAYFIELD, R. and SPENDLOVE, I., 2007. The ubiquitin-binding protein p62 is expressed in breast cancers showing features of aggressive disease Endocrine-Related Cancer. 14(1), 73-80 ATHANASIOU, ANDRIANI, SMITH, PAUL A, VAKILPOUR, SARA, KUMARAN, NETHIA M, TURNER, AMY E, BAGIOKOU, DIMITRA, LAYFIELD, ROBERT, RAY, DAVID E, WESTWELL, ANDREW D, ALEXANDER, STEPHEN P H and KENDALL, DAVID A, 2007. Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications. 354(1), 50-5 CHUTHAPISITH, S, LAYFIELD, R, KERR, I D and EREMIN, O, 2007. Principles of proteomics and its applications in cancer. The Surgeon. 5(1), 14-22 CHUTHAPISITH, S, LAYFIELD, R, KERR, ID, HUGHES, C, EREMIN, O, 2007. Proteomic profiling of MCF-7 breast cancer cells with chemoresistance to different types of anti-cancer drugs. International Journal of Oncology. 30(6), 1545-51
LAYFIELD, R, SHAW, B, 2007. Ubiquitin-mediated signalling and Paget's disease of bone. BMC Biochemistry. 8 Suppl 1, S5 TOMLINSON, E, PALANIYAPPAN, N, TOOTH, D, LAYFIELD, R, 2007. Methods for the purification of ubiquitinated proteins. Proteomics. 7(7), 1016-22 LAYFIELD, R, 2007. The molecular pathogenesis of Paget disease of bone. Expert Reviews in Molecular Medicine. 9(27), 1-13
MATHAROO-BALL, B, HUGHES, C, LANCASHIRE, L, TOOTH, D, BALL, G, CREASER, C, ELGASIM, M, REES, R, LAYFIELD, R and ATIOMO, W, 2007. Characterization of biomarkers in polycystic ovary syndrome (PCOS) using multiple distinct proteomic platforms. Journal of Proteome Research. 6(8), 3321-8 CAVEY, J. R., RALSTON, S. H., SHEPPARD, P. W., CIANI, B., GALLAGHER, T. R. A., LONG, J. E., SEARLE, M. S. and LAYFIELD, R., 2006. Loss of ubiquitin binding is a unifying mechanism by which mutations of SQSTM1 cause Paget's disease of bone Calcified Tissue International. 78(5), 271-277 HUGHES, C., ELGASIM, M., LAYFIELD, R. and ATIOMO, W., 2006. Genomic and post-genomic approaches to polycystic ovary syndrome-progress so far : mini review Human Reproduction. 21(11), 2766-2775 LAYFIELD, R, CAVEY, J R, NAJAT, D, LONG, J, SHEPPARD, P W, RALSTON, S H and SEARLE, M S, 2006. p62 mutations, ubiquitin recognition and Paget's disease of bone. Biochemical Society Transactions. 34(Pt 5), 735-7
HOPKINSON, A., MCINTOSH, R.S., LAYFIELD, R., KEYTE, J., DUA, H.S. and TIGHE, P.J., 2005. Optimised two-dimensional electrophoresis procedures for the protein characterisation of structural tissues Proteomics. 5(7), 1967-1979 CAVEY, J. R., RALSTON, S. H., HOCKING, L. J., SHEPPARD, P. W., CIANI, B., SEARLE, M. S. and LAYFIELD, R., 2005. Loss of ubiquitin-binding associated with Paget's disease of bone p62 (SQSTM1) mutations Journal of Bone and Mineral Research. 20(4), 619-624 LAYFIELD, R., LOWE, J. and BEDFORD, L., 2005. The ubiquitin-proteasome system and neurodegenerative disorders Essays in Biochemistry. VOL 41, 157-171 HOCKING, LYNNE J, LUCAS, GAVIN J A, DAROSZEWSKA, ANNA, CUNDY, TIM, NICHOLSON, GEOFF C, DONATH, JUDIT, WALSH, JOHN P, FINLAYSON, CATRIONA, CAVEY, JAMES R, CIANI, BARBARA, SHEPPARD, PAUL W, SEARLE, MARK S, LAYFIELD, ROBERT and RALSTON, STUART H, 2004. Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: genotype phenotype correlation, functional analysis, and structural consequences. Journal of Bone and Mineral Research. 19(7), 1122-7 LAYFIELD, R., CIANI, B., RALSTON, S. H., HOCKING, L. J., SHEPPARD, P. W., SEARLE, M. S. and CAVEY, J. R., 2004. Structural and functional studies of mutations affecting the UBA domain of SQSTM1 (p62) which cause Paget's disease of bone Biochemical Society Transactions. VOL 32(PART 5), 728-730 LAYFIELD, R. and HOCKING, L. J., 2004. SQSTM1 and Paget's Disease of Bone Calcified Tissue International. VOL 75(NUMB 5), 347-357 LAYFIELD, ROBERT, CAVEY, JAMES R and LOWE, JAMES, 2003. Role of ubiquitin-mediated proteolysis in the pathogenesis of neurodegenerative disorders. Ageing Research Reviews. 2(4), 343-56 ALEXEEV, D., BARLOW, P. N., BURY, S. M., CHARRIER, J.-D., COOPER, A., HADFIELD, D., JAMIESON, C., KELLY, S. M., LAYFIELD, R., MAYER, R. J., MCSPARRON, H., PRICE, N. C., RAMAGE, R., SAWYER, L., STARKMANN, B. A., UHRIN, D., WILKEN, J. and YOUNG, D. W, 2003. Synthesis, structural and biological studies of ubiquitin mutants containing (2S, 4S)-5-fluoroleucine residues strategically placed in the hydrophobic core ChemBioChem. 4(9), 894-896 CIANI, B., LAYFIELD, R., CAVEY, J. R., SHEPPARD, P. W. and SEARLE, M. S., 2003. Structure of the ubiquitin-associated domain of p62 (SQSTM1) and implications for mutations that cause Paget's disease of bone Journal of Biological Chemistry. 278(39), 37409-37412 WILKINS, A., MAJED, H., LAYFIELD, R., COMPSTON, A. and CHANDRAN, S., 2003. Oligodendrocytes Promote Neuronal Survival and Axonal Length by Distinct Intracellular Mechanisms: A Novel Role for Oligodendrocyte-Derived Glial Cell Line-Derived Neurotrophic Factor Journal of Neuroscience. VOL 23(PART 12), 4967-4974 DAVID, D.C., LAYFIELD, R., SERPELL, L., NARAIN, Y., GOEDERT, M. and SPILLANTINI, M.G, 2002. Proteasomal degradation of tau protein. Journal of Neurochemistry. 83(1), 176-185 LOWE, J, MAYER, J, LANDON, M and LAYFIELD, R, 2001. Ubiquitin and the molecular pathology of neurodegenerative diseases. Advances in Experimental Medicine and Biology. 487, 169-86
LAYFIELD, R, ALBAN, A, MAYER, R J and LOWE, J, 2001. The ubiquitin protein catabolic disorders. Neuropathology and Applied Neurobiology. 27(3), 171-9 LAYFIELD, R, TOOTH, D, LANDON, M, DAWSON, S, MAYER, J and ALBAN, A, 2001. Purification of poly-ubiquitinated proteins by S5a-affinity chromatography. Proteomics. 1(6), 773-7 LAM, Y. A., PICKART, C. M., ALBAN, A., LANDON, M., JAMIESON, C., RAMAGE, R., MAYER, R. J. and LAYFIELD, R., 2000. Inhibition of the ubiquitin-proteasome system in Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America. VOL 97(PART 18), 9902-9906