The 6th Baron was the only son of the 5th Baron Middleton and succeeded his father in 1800. He employed the architect Jeffry Wyatt, otherwise Wyatville, to make extensive alterations to Wollaton Hall. He died on 19 June 1835 and was succeeded by his cousin, Digby Willoughby, as 7th Baron Middleton .
He married Jane, daughter of Sir Robert Lawley, Baronet, in 1793 (d 1852). They had no children.
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