[Centre for Mathematical Medicine and Biology Seminar]
Viji Chelliah (Certara QSP, UK)
Quantitative Systems Pharmacology (QSP): Applications in Drug Discovery and Development
A large proportion of drug development projects fail in phase II and phase III clinical trials mainly because of the lack of efficacy and unacceptable safety profile. Arguably, the fundamental origin of the high attrition rates in drug development amongst others is due to the lack of understanding of the complexity of disease biology and the targets’ interactome. Modelling and simulation play a critical role in organizing diverse data sets and exploring alternate study designs. Quantitative systems pharmacology (QSP), in particular, is now increasingly being employed to translate the rapidly growing understanding and mapping of complex biology and pathophysiology into a solid foundation for the efficient and rational development of novel modalities, combination therapy and innovative treatment regimens to treat diseases in high medical need areas. This enables safe and effective new therapeutics to advance more efficiently through the different stages of drug discovery and development.
The University of NottinghamUniversity Park Nottingham, NG7 2RD
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