Monday, 10 January 2022
New research is developing a new formulation of a common metabolic inhibitor (niclosamide) that could turn it into apromising prophylactic/preventative nasal spray and early treatment throat spray for Covid-19.
A flurry of papers in the literature this past year has shown that niclosamide can 100% halt the replication of the SARS-COV2 virus. Following this work, David Needham, Professor of Translational Therapeutics in the School of Pharmacy at the University of Nottingham and Professor of Mechanical Engineering and Materials Science at Duke University, has shown that a simple slight increase in solution pH might be all it takes to turn a drug, that he has already repurposed in new research for cancer, into a promising prophylactic/preventative nasal spray and early treatment throat spray for COVID-19 and is now ready for testing. The research has been published in the journal Pharmaceutical Research.
In its original anti-parasitic application, niclosamide has been used for over 60 years, taken as oral tablets, killing tapeworms on contact in the gut by inhibiting their crucial metabolic pathway and shutting down their energy supply. This same ability to lower the energy supply in a cell, has shown that it can also reduce the energy a virus needs to replicate. However, niclosamide’s poor solubility in water makes it very difficult to use elsewhere.
Recent unpublished studies by Needham’s collaborators (in the labs of Christina Barkauskas, MD and Patty Lee MD) at Duke, used human airway cells, and suggested that increasing the normally low water solution concentration by 10 times might be enough for the drug to work on respiratory viruses in patients.
The new formulation research demonstrates that simply raising the pH of a solution to a slightly alkaline pH 8.0, which is an acceptable range for a nasal spray, can dissolve enough niclosamide to be effective in the preliminary lab studies with human airway cells. And raising the pH to 9.2, which is still tolerable for a throat spray, beats that benchmark by 10 times over and so could be used in early infection.
Professor Needham explains: “For cells that could be infected or already are infected, niclosamide acts by turning down the dimmer switch on those host cells so that the virus cannot use the cell’s own machinery to replicate. Used as a nasal spray it could be added protection behind the mask, and therefore has the potential to reduce or eliminate the viral load in the nasal cavity where initial infection and replication takes place. It essentially puts the virus in lockdown”
He continues: “Because it works on the host cells rather than the virus, niclosamide could function as a respiratory viral preventative/prophylactic agent, not just against COVID-19 and all of its variants, but against any new virus as well. While vaccines are clearly effective, a nasal preventative would be added protection. And even if an infection has already taken hold, this formulation could be used as an early treatment throat spray that could stop the viral load heading toward the lungs that causes the disease’s most devastating effects. It just needs testing”
David is actively seeking industry and preferably government and infectious disease institute partners to help pursue clinical trials, manufacturing, and distribution across the world.
For more information visit this website
More information is available from Professor David Needham at email@example.com
Notes to editors:
The University of Nottingham
Ranked 18th in the UK by the QS World University Rankings 2023, University of Nottingham is a founding member of Russell Group of research-intensive universities. Studying at the University of Nottingham is a life-changing experience, and we pride ourselves on unlocking the potential of our students. We have a pioneering spirit, expressed in the vision of our founder Sir Jesse Boot, which has seen us lead the way in establishing campuses in China and Malaysia - part of a globally connected network of education, research and industrial engagement.
The University is among the best universities in the UK for the strength of our research, positioned seventh for research power in the UK according to REF 2021. The birthplace of discoveries such as MRI and ibuprofen, our innovations transform lives and tackle global problems such as sustainable food supplies, ending modern slavery, developing greener transport, and reducing reliance on fossil fuels.The University is a major employer and industry partner - locally and globally - and our graduates are the second most targeted by the UK's top employers, according to The Graduate Market in 2022 report by High Fliers Research.
We lead the Universities for Nottingham initiative, in partnership with Nottingham Trent University, a pioneering collaboration between the city’s two world-class institutions to improve levels of prosperity, opportunity, sustainability, health and wellbeing for residents in the city and region we are proud to call home.