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Experts urge delayed surgery patients to increase fitness training during COVID-19

Tuesday, 07 April 2020

Physiology experts are urging people on surgical waiting lists to consider using high-intensity interval training (HIIT) to boost the fitness of their heart and lungs during the COVID-19 pandemic.

The team of scientists at the University of Nottingham say their new research proves the benefit of HIIT in patients having surgery for urological cancer – results that are also relevant to everyone trying to avoid or recover from COVID-19.

In a paper published in a Nature journal, the researchers show how a group of older pre-surgical patients significantly benefitted from a cycling-based HIIT exercise programme in the month running up to their operations. The results suggest that this HIIT regime has the potential to reduce the chances of complications or death during and after surgery.

Dr James Blackwell, Royal Derby Hospital and University of Nottingham

Dr James Blackwell from the Royal Derby Hospital and the University’s School of Medicine said: “We set out to find out what effect a simple programme of HIIT had on patients waiting for surgery for prostate, kidney and bladder cancer and were pleased to see clear positive changes with this very specific type of supervised exercise. HIIT significantly improved cardio-respiratory function in our intervention group of patients, but larger trials are needed to see what difference it makes on post-operative complications, socio-economic impact and long-term survival. The COVID-19 pandemic may result in patients waiting longer for scheduled operations, it is essential that fitness levels do not drop during this time. There may be opportunity for patients to improve baseline fitness levels prior to surgery."

Associate Professor Beth Phillips, University of Nottingham

Dr Bethan Phillips also from the University’s School of Medicine said: “We think the results of our trial have implications for the wider community in the light of the COVID-19 pandemic. We would advise everyone to try and increase their fitness by using simple programmes of HIIT which are freely available online, many of which can be done in the home or garden without special equipment. It’s so important that people stay fit as it improves their chances of fighting off COVID-19 or limiting the effects of the infection. This includes eating a healthy diet and cutting back on alcohol and smoking.”

In the HIIT randomised controlled trial for pre-operative patients, 40 people were recruited with an average age of 72. All patients were awaiting major urological surgery for cancer – operations which have relatively high rates of peri- and post-operative complications. The patients were randomised into either the control group for standard care, or a 4-week fully supervised HIIT intervention in the run-up to their operations. Measurements of cardio-respiratory fitness and muscle mass were taken before the first HIIT session and again a few days before surgery. The HIIT exercise consisted of a warm up on a static exercise bike then 5 x 1-minute bursts of cycling at the patient’s highest level of effort, followed by 90 second recovery periods of unloaded cycling and a two minute warm down.

There was a statistically significant reduction in the HIIT group’s resting blood pressure and also an increase in both the submaximal (anaerobic threshold) and maximum rate of oxygen they used (aerobic capacity) after the month-long period of the exercise trial. The researchers say these effects can have real benefits in helping patients who undergo surgery with fitter patients suffering fewer post-operative complications and recovering more quickly afterwards.

The study also shows that it is possible to make a meaningful difference in the fitness of patients in a relatively short space of time before their operations. Most urological surgery is carried out within 31 days of a decision to operate. Previously urology surgical patients have been given pelvic floor exercises to help avoid incontinence after operations but the HIIT intervention has the capacity to improve a wider range of aspects of fitness.

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For more information please contact Associate Professor Beth Phillips from the School Medicine at the University of Nottingham, email beth.phillips@nottingham.ac.uk or Emma Rayner, Media Relations Manager for the Faculty of Arts on +44 (0)115 951 5793 emma.rayner@nottingham.ac.uk 

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The University of Nottingham is a research-intensive university with a proud heritage. Studying at the University of Nottingham is a life-changing experience and we pride ourselves on unlocking the potential of our students. We have a pioneering spirit, expressed in the vision of our founder Sir Jesse Boot, which has seen us lead the way in establishing campuses in China and Malaysia - part of a globally connected network of education, research and industrial engagement. Ranked 103rd out of more than 1,000 institutions globally and 18th in the UK by the QS World University Rankings 2022, the University’s state-of-the-art facilities and inclusive and disability sport provision is reflected in its crowning as The Times and Sunday Times Good University Guide 2021 Sports University of the Year. We are ranked eighth for research power in the UK according to REF 2014. We have six beacons of research excellence helping to transform lives and change the world; we are also a major employer and industry partner - locally and globally. Alongside Nottingham Trent University, we lead the Universities for Nottingham initiative, a pioneering collaboration which brings together the combined strength and civic missions of Nottingham’s two world-class universities and is working with local communities and partners to aid recovery and renewal following the COVID-19 pandemic.

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