Research goes to new depths in skin peptide study

Tuesday, 25 May 2021

Researchers have revealed for the first time that a peptide in a leading beauty product can penetrate the tough stratum corneum barrier of the skin.

A study between the University of Nottingham and No7, the UK’s number one skincare brand, used leading-edge technology to track the penetration of No7’s peptide blend Matrixyl 3000+™ following topical application to the skin surface. The findings offer an improved understanding of the bioavailability of topically applied peptides and provides further evidence for the efficacy of wrinkle targeting peptides.

Researchers used a tape-stripping method to remove layers of skin from study participants, in vivo, whilst maintaining the integrity of layers and structural features. A recently developed hybrid secondary ion mass spectrometry technique, 3D OrbiSIMS, was employed in the blinded study and detected the peptide penetrating into the tough stratum corneum barrier – the major obstacle and rate limiting step for the delivery of active ingredients into the skin (n=12; p<0.05 vs untreated).

The study used a recently popularised analytical technique to identify the peptide ten surface layers deep into the skin, whilst preserving the skin structure. Many other techniques rely on preparing skin samples for analysis by freeze-drying, fixing or staining, and therefore cannot be truly sure of the depth measured. “Never before have we been able to analyse the real-life penetration of the peptides in No7 in such detail,” writes Dr Mike Bell, No7 skincare scientific advisor:

For the first time, it has been possible to trace and detect the peptides responsible for tackling invisible photo-damage that occurs early in the ageing process. The 3D OrbiSIMS technique has opened up the possibility to track exactly where our peptides go to in the skin; now there are new insights into how to optimise delivery to make peptides even more effective.

David Scurr, Senior Research Fellow, School of Pharmacy

The flagship brand of the newly formed No7 Beauty Company, No7 was the first beauty brand in the UK to be able to demonstrate long term clinical and cumulative reductions in the appearance of lines and wrinkles on its Protect & Perfect Intense Advanced Serum. Since their creation, more than 5,000 women have been involved in the testing of all of No7’s serums across nearly 80 trials. In scientifically controlled clinical trials, over 90% achieved a visible reduction in the appearance of wrinkles. The company’s comprehensive approach to testing has proven that the serums dramatically slow the appearance of key signs of ageing, with advanced formulations that target damage; and now, its most recent testing with the 3D OrbiSIMS technique has given even greater insights into the powerful technology at the heart of the serums.

The University of Nottingham was the first University in the world to own and operate the 3D OrbiSIMS instrument. The technology facilitates an unprecedented level of molecular analysis for a range of materials including biological tissues, such as human skin. Importantly, its high mass resolving power, chemical specificity and high sensitivity allow it to be used on human skin samples to identify and analyse low concentrations of active ingredients that resemble native components of the skin, such as collagen peptides.

“This level of analysis of the Matrixyl 3000+™ peptide blend has not been possible until now. In the future, the technology may also allow us to identify new biochemical biomarkers of ageing and disease,” says Dr Mike Bell.

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Notes to editors:

The University of Nottingham is a research-intensive university with a proud heritage. Studying at the University of Nottingham is a life-changing experience and we pride ourselves on unlocking the potential of our students. We have a pioneering spirit, expressed in the vision of our founder Sir Jesse Boot, which has seen us lead the way in establishing campuses in China and Malaysia - part of a globally connected network of education, research and industrial engagement. Ranked 103rd out of more than 1,000 institutions globally and 18th in the UK by the QS World University Rankings 2022, the University’s state-of-the-art facilities and inclusive and disability sport provision is reflected in its crowning as The Times and Sunday Times Good University Guide 2021 Sports University of the Year. We are ranked eighth for research power in the UK according to REF 2014. We have six beacons of research excellence helping to transform lives and change the world; we are also a major employer and industry partner - locally and globally. Alongside Nottingham Trent University, we lead the Universities for Nottingham initiative, a pioneering collaboration which brings together the combined strength and civic missions of Nottingham’s two world-class universities and is working with local communities and partners to aid recovery and renewal following the COVID-19 pandemic.

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