Wednesday, 09 July 2025
Nottingham researchers are calling for volunteers to help with a new study into typhoid and paratyphoid A, which sees 13 million cases every year.
The study is looking for healthy volunteers to take part in the study to test a new vaccine against typhoid and paratyphoid A fever, highly contagious and potentially life-threatening infections.
In order to test if the vaccine works to protect against paratyphoid A fever, after vaccination with the new vaccine or a control vaccine, they will be challenging all participants with the bacteria that could cause paratyphoid fever.
Participants will be treated with antibiotics as soon as they show symptoms of infection, or 14 days after drinking the bacteria even if they do not have symptoms.
The study is being run by the University of Nottingham Health Service, in collaboration with the Oxford Vaccine Group, and is funded by the Serum Institute of India.
Participants for the trial should be aged between 18 and 55 years old, and in good health, and will be provided with reimbursement for time, inconvenience, and travel. Participants will receive up to £4,410 if they remain in the study for the entire period and attend all the scheduled visits required for them.
With this study, we're aiming to evaluate a promising new vaccine that could help protect against paratyphoid A fever, a serious illness that affects millions each year. We’re looking for healthy volunteers to help us take an important step toward improving global health.”
The total study participation time is 7 months, with participants required to attend the University of Nottingham Health Service (Cripps Health Centre) and Nottingham University Hospitals – Queen’s Medical Centre site for all study visits and Oxford Vaccine Group on challenge administration day (travel will be arranged).
More information about the study is available on the website here: https://www.ovg.ox.ac.uk/studies/bivista/nottingham
Further information regarding the study, is also available on: nnicb-nn.research@nhs.net
Story credits
More information is available on nnicb-nn.research@nhs.net
Faith Pring - Media Relations Manager
Email: faith.pring@nottingham.ac.uk
Phone: 0115 748 4411
Location: University of Nottingham, University Park
Notes to editors:
About the University of Nottingham
Ranked 97 in the world and 17th in the UK by the QS World University Rankings, the University of Nottingham is a founding member of Russell Group of research-intensive universities. Studying at the University of Nottingham is a life-changing experience, and we pride ourselves on unlocking the potential of our students. We have a pioneering spirit, expressed in the vision of our founder Sir Jesse Boot, which has seen us lead the way in establishing campuses in China and Malaysia - part of a globally connected network of education, research and industrial engagement.
Nottingham was crowned Sports University of the Year by The Times and Sunday Times Good University Guide 2024 – the third time it has been given the honour since 2018 – and by the Daily Mail University Guide 2024.
The university is among the best universities in the UK for the strength of our research, positioned seventh for research power in the UK according to REF 2021. The birthplace of discoveries such as MRI and ibuprofen, our innovations transform lives and tackle global problems such as sustainable food supplies, ending modern slavery, developing greener transport, and reducing reliance on fossil fuels.
The university is a major employer and industry partner - locally and globally - and our graduates are the third most targeted by the UK's top employers, according to The Graduate Market in 2024 report by High Fliers Research.
We lead the Universities for Nottingham initiative, in partnership with Nottingham Trent University, a pioneering collaboration between the city’s two world-class institutions to improve levels of prosperity, opportunity, sustainability, health and wellbeing for residents in the city and region we are proud to call home.
More news…