Understanding the role of dietary fibre in protecting the gut

Lead researcher: Dr Gleb Yakubov

Fibre is a key component of a healthy diet and yet most people in the UK do not achieve the recommended intake. The exact impact of fibre on overall digestive health is unknown, partly because the fundamental mechanisms of how fibre ‘works’ in the human body are not understood. 

This project focuses on the role of dietary fibre in the protection of the gut and its mucus lining. Mucus secretions are vital for gut health because they form a physical barrier and support healthy gut microbiota. Focusing on the mucus biophysical properties, the project explores the role of biophysical factors to identify mechanisms by which dietary fibre affects barrier and protective functionality of mucus to ensure digestive organs remain in good working order.

This project is funded by BBSRC.