Allergy and Infectious Diseases

Development of new reporter systems for detection of sensitisation with allergen-specific IgE

Together with our collaborator Dr Marcos Alcocer we have developed a series of reporter cell lines humanised with the human IgE receptor which report events associated with IgE crosslinking by producing intracellular green or red fluorescent proteins (Wang et al. 2013 ). These are suitable for use in microarray-based detection systems such as the live basophil allergen array previously developed in our labs (Lin et al., 2007 ). This work was recognised by a Breakthrough Technology da Vinci Healthcare Award in 2008:



 Our cell lines can be obtained for non-commercial purposes on the basis of an MTA.

Allergy and Infectious Diseases

The University of Nottingham
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