Sir Peter Mansfield Imaging Centre

Novel brain mapping and modulations

Neuroimaging uses medical imaging technologies to study the structure and function of the brain for medicine, neuroscience and psychology. We study​:

  • Anatomy, particularly exploiting increased spatial resolution at 7T to investigate small structure of and the versatile contrast of MRI to study changes in tissue properties.

  • Brain function using fMRI and the BOLD effect (which depends on the changes in blood flow oxygenation) and electrical activity monitored by MEG (Magnetoencephalography) and EEG (Electroencephalography).
  • Physiology in particular blood flow and oxygenation, both investigate the origins of the heamodynamic response to activation (underpinning fMRI) and to study change in disease such as a stroke or cancer.
  • Metaolism and biochemistry using magnetic resonance spectroscopy.

We use computational neuroimaging to link these measures together to get new insights into how the brain works. 

We can also investigate neurodevelopment, using OPM-MEG technology developed in Nottingham that adapts to different head shapes and tolerates free-movement during a recording.

fmri1
High resolution fMRI can allow the representation of individual digits to be determined within the brain’s grey matter (cortical representation of digits).
 
Structural images
Strutural MRI showing cochlea (above) and hippocampus (below).
 
 

 

OPM_vol_and_data

OPM-MEG scanning across all age ranges can be used to study the variation in functional connectivity across the lifespan.

 

 

Prominent research