| Project Title | Supervisor & Email |
|---|
| How are some human skeletal muscles spared from atrophy-inducing signals? |
Bethan Phillips |
| Mitochondrial dysfunction in renal proximal tubule underpins kidney disease in all animals |
David Gardner |
| Path analysis of connectomes (NTU) |
Jason Smith |
| Non-structural protein 6 as a pan-coronavirus immunomodulatory protein |
Christopher Coleman |
| Towards the development of a pan-lineage vaccine: antigenic mapping of lassa fever virus glycoproteins |
Janet Daly |
| Does sweet tooth associate with the risk of developing type 2 diabetes? |
Qian Yang |
| Gene switches and treatment resistance in advanced cancer |
Nigel Mongan |
| Understanding the role of extracellular vesicles in the regulation of RNA |
Victoria James |
| Understanding the role of lysine methyltransferases in ovarian cancer progression and treatment resistance |
Jennie Jeyapalan |
| Antisense transcripts as novel biomarkers involved in the pathogenesis of ovarian cancer |
Cinzia Allegrucci |
| Using neuroimaging to examine brain structural and functional connectivity |
Tracy Farr |
| Investigating tRNA fragments as biomarkers of amyloidosis and alpha-synucleinopathies (NTU) |
Marion Hogg |
| Determining the influence of sex hormones on central and peripheral aspects of motor function across the lifespan (NTU) |
Jessica Piasecki |
| Behaviour and Addiction: Inhibition of Pavlovian-Instrumental Transfer |
Charlotte Bonardi |
| Exosome biogenesis and organelle trafficking in neurodegeneration |
Alistair Hume |
| Evolution and plasticity of human cognition |
Deborah Serrien |
| Understanding how particulate matter and respiratory viruses influence respiratory ageing using immune competent stem cell derived lung organoids |
Nicholas Hannan |
| Hippocampo-prefrontal-subcortical circuit in cognition and behaviour |
Tobias Bast |
| The use of Drosophila melanogaster neuronal imaging as a novel tool to test the efficacy of putative Alzheimer's disease drug candidates |
Marios Georgiou |
| Physiology, pathology and drug delivery opportunities associated with the lymphatic system of the rectim in animals and humans |
Pavel Gershkovich |
| Exploring the bio-instructive properties of glycosaminoglycans |
Andrew Hook |
| Genetic and biological rhythm drivers of molecular metabolism in fat and muscle (NTU) |
Rebecca Dumbell |
| Cracking the Code: Structural Basis for Regulation of Gene Transcription in HIV |
Aditi Borkar |
| Proteomic and electrophysiological features of the aged human neuromuscular junction |
Mathew Piasecki |
| Investigating the neurobiological mechanisms of psychedelics and their potential to treat affective disorders |
Claire Gibson |
| Using machine learning to uncover patterns in the evolution of protein sequence and function across eukaryote genomes (NTU) |
Maria Rosa Domingo Sananes |
| Safeguarding DNA in Humans: Understanding structure and function in the tumour suppressor 'hub' HELQ-RPA-POLD-CX3 |
Ed Bolt |
| Multi-omics to identify placental epigenetic interactions associated with micronutrient deficiency in pre-eclampsia (NTU) |
Adaikala Antonysunil |
| Synthetic emrbyology: How to build a mammalian embryo |
Ramiro Alberio |
| Understanding lymph node determinants of therapy response |
Jacqui Shields |
| Investigations into the pangenomic diversity of the Prairie Epidemic Strain (PES) of Pseudomonas aeruginosa |
Fiona J Whelan |
| Role of Glial Fibrillary Protein (GFAP) in the response to Neuronal Degeneration and Injury |
Claire Friel |
| Understanding the lifetime accumulation of antimicrobial resistance genes in the human gut microbiome |
Dov Stekel |
| Neural and behavioural mechanisms of cognitive flexibility: intergrative neuroscience studies of the overtraining reversal effect |
Silvia Maggi |
| Developing nanoscale structural and compositional techniques for vascular pathologies |
Kenton Arkill |
| Assessment of protease and ligand-induced PAR2 conformational changes and its subcellular trafficking in living cells - how is inflammatory pain initiated? |
Raphael Silvanus Haider |
| Design and development of Gi peptide biosensors for the interrogation of signal transduction processes in G protein-coupled receptors (GPCRs) |
Charlie Laughton |
| How the spinal cord talks to the brain: Illuminating the sensory output system of the spinal cord |
Kim Chisholm |
| Telling tails: using computer-based approaches to understand the roles poly(A) tails in gene expression |
Keith Spriggs |
| The regulatoin of multipotent stormal cell functions in inflammegeing; a focus on miRNA roles (NTU) |
Jehan El-Jawhari |
| Understanding the role of actin nucleation in the cellular stress response (NTU) |
Amanda Coutts |
| The striatum as a recurrent neural network |
Mark Humphries |
| Investigating regulatory mechanisms of the AP1 transcription factor in hypoxic (low oxygen) cell adaptation |
Alan McIntyre |
| Signal boost: Exploiting the solvent effect to optimise signal and functional performance in genetically expressed fluorophores and FRET sensors |
Kevin Webb |
| The role of potassium ion channels in central nervous system cell division and stemness |
Stuart Smith |
| Deciphering the functional solution structure and structure-activity profile of the macrocyclic antibiotic zelkovamycin |
Weng Chan |
| Characterisation of potentially pathogenic enteric viruses from the River Trent, Derbyshire, UK |
Kenneth Mellits |
| Advances in genetic mechanisms and pathway analysis towards diagnostic, prognostic and treatment opportunities for osteosarcoma |
Catrin Rutland |
| Using computational methods to predict child cognitive development and mental health |
Sobana Wijeakumar |
| Do Archaea use Conservative DNA Synthesis in the absence of replication origins? |
Thorsten Allers |
| Sexual dimorphic impacts of glucocorticoids upon metabolic resilience (NTU) |
Craig Doig |
| Ageing, neurodegeneration and oxygen - does nature have an alternative to haemoglobin for us? |
Lisa Chakrabarti |
| Investigating the influence of the tumour microenvironment in 3D models of Diffuse Midline Gliomas |
Beth Coyle |
| Exploring the potential of methenamine as a novel approach for urinary tract infection treatment (NTU) |
Alasdair Hubbard |
| The effect of physical activity on the immune system in physically inactive older adults (NTU) |
John Hough |
| Immunity in the face of diversity and the development of protective vaccines against African trypanosomes |
Catarina Gadelha |
| What is the fact of silver in silver resistant bacteria? |
David Scott |
| The exploration of brain-penetrant analogues of cannabidiol (CBD) for enhanced targeting of treatment-resistant cancers |
Shailesh Mistry |
| Using Artificial Intelligence approaches for the design of new bacteria for synthetic biology, health and environmental biology |
James McInerney |
| Characterisation of equine asthma endotypes |
Sarah Blott |
| Combining C-H functionalization and SuFEx click chemistry for peptide bioconjugation (NTU) |
Warren Cross |
| Developing bismuth-based broad-spectrum antivirals for human and animal health (NTU) |
Sophie Benjamin |
| Do ligands with different chemical structures impact conformational changes in GPCRs? |
Shahida Mallah |
| Applying RNA Interference Technology to understand the role of 1q amplification in multiple myeloma pathogenesis (NTU) |
Zahraa Al-Ahmady |
| Cancer-related cognitive impairment: investigating the impact of peripheral tumours on neuronal plasticity in the brain |
Graham Sheridan |
| Can a bad cell turn good? Investigating metabolic resilience of reactive astrocytes in the immune response to brain cancer |
Sebastien Serres |
| Sugar addiction - is it all in your genes or all in your tongue? |
Peter Aldiss |
| Diminished astrocyte-neuron interactions induces sensory neurodegeneration due to disturbance in metabolic homeostasis (NTU) |
Richard Hulse |
| Does carbonation and non-sugar sweetners in carbonated beverages impact appetite sensation? |
Sally Eldeghaidy |
| How does survivin inhibit apoptosis? |
Sally Wheatley |
| "Receptor Activity-Modifying proteins (RAMPs) as novel pharmacological intervention to target Vasopressin receptor nanodomain" |
Isabella Maiellaro |
| Investigating the anti-inflammatory effects of celecoxib and loxoprofen in glioblastoma (GBM) with and without bio-nanoantennae electrical stimulation |
Frankie Rawson |
| How does Fusobacterium nucleatum cause gum disease? The contribution of nucleotide second messengers to virulence pathways (NTU) |
Sarah Kuehne |
| Deubiquitinase structure determination for drug design |
Jonas Emsley |
| Design and development of allosteric modulators for human beta-adrenoceptors |
Barrie Kellam |
| Dissecting quality control of bacterial outer membrane biogenesis |
Jack Bryant |
| Developing induced pluripotent stem cell-derived human skeletal muscle models to investigate healthy and pathological ageing |
Matthew Brook |
| Does pregnancy alter sweet taste perception and sweet food cravings |
Matthew Elmes |
| Self-assembled theranostics: combing PARASHIFT MRI with drug delivery |
Ben Pilgrim |
| Effect of the extracellular matric on metabolite regulation and distribution in primary human macrophages |
Anna Piccinini |
| Pluripotent stem cell research related to human development and regenerative medicine |
Masaki Kinoshita |
| Mammalian stem cells: an experimental platform to study epigenetic changes in development and neurodegenerative disorders |
Reinhard Stoger |
| Facilitating protein degradation to impair cell survival (NTU) |
Cristina Montiel-Duarte |
| Assessment of a Genomic Informational Field Theory (GIFT) for genetic analysis of complex traits in high performing atheletes (NTU) |
Ian Varley |
| Exploring the role of Endoplasmic Reticulum (ER) - targeting pathway changes in cancer |
Natalie Mack |
| Understanding the hierarchy of cell division in trypanosome parasites |
Bill Wickstead |
| Defining the role of fucosyltransferase 2 (FUT2) genetic variants in airway mucocilliary function and inflammatory crosstalk |
Ian Sayers |
| Genomic characterization of Staphyloccus haemolyticus and associated bacteriophage (NTU) |
Jonathan Thomas |
| The contribution of glycation signalling to unhealthy aging and neurodegeneration |
Joern Steinert |
| Defining the biophysical properties of chromosomes |
Daniel Booth |
| Cardiovascular regulation by insulin-like growth factor receptor 1 |
Samantha Cooper |
| Exploring the interplay of miRNA, circular RNA and long non coding RNA with the transcriptional regulators KAT6A and KAT6B |
Hilary Collins |
| Investigating the macrophace-mast cells cross-talk and its role in cancer |
Anna Malecka |
| Ladybird alkaloid, Harmonine, and analogues for inhibition of NDMA receptors and acetylcholinesterase in Alzheimer's Disease |
Ian Mellor |
| Reconstitution of mRNA deadenylation by components of the microRNA repression machinery |
Sebastiaan Winkler |
| Synthesis of fluorescently labelling ligands for the atypical chemokine receptor 3 (ACKR3) |
Luke Steven Schembri |
| How dos GPCR/RAMP signalling co-ordinate blood-brain barrier development? |
Rob Wilkinson |
| Studies of GPCR signalling using single molecule protein-protein interaction quantum biosensors |
Dmitry Veprintsev |
| Mesoporous metal surfaces as novel platforms for SERS-based biomedical diagnostics (NTU) |
Anna Vikulina |
| Mapping adenosine receptor interactomes in human cells utilising NanoBRET protein-protein interaction & CRISPR/Cas9 mediated proximity proteomics |
Laura Kilpatrick |
| CRISPR generated models of Human KAT6 Syndromes: can we restore function? |
David Heery |
| The effect of the menopause on cognitive function and visual attention |
Laurence Warren-Westgate |
| HYBRID Multifunctional Scaffolds for Guided Tissue Regneration: combating Periodontitis and Associated Infections (NTU) |
Dmitry Volodkin |
| Developing a model of the ageing neuroimmune system |
Andrew Bennett |
| The extracellular vesicles transglutaminase-2 in regulating early synaptic dysfunction in Alzheimer's disease (NTU) |
Elisabetta Verderio Edwards |
| Mechanistic Springboard for Healthcare Driven Portable Sodium Sensors |
Galina Pavlovskaya |
| Characterising a novel chemogenetic method for inducing aberrant adult hippocampal neurogenesis (NTU) |
Edward Beamer |
| Targetting human prolyl oligopepditidase (HuPOP) in inflammation |
Ivan Campeotto |
| Unravelling the role of mitochondrial sulfide oxidation in diabetic neurodegeneration (NTU) |
Nicholas (Nik) Morton |
| Robustness of the blood cell development during vertebrate embryogenesis |
Martin Gering |
| Investigating the causal role of brain rhythms for cognitive flexibility in the ageing brain |
Nicholas Myers |
| Multimodal brain networks in cognition |
Roni Tibon |
| The role of melanopsin-based photoreception in visual analysis |
Paul McGraw |
| Peturb and record: a multimodal approach to the study of brain connectivity in the attentional network |
Domenica Veniero |
| Influences of anxiety on learning and memory |
Christopher Madan |
| Neural underpinnings of driving behaviour |
Matias Ison |
| The neurochemical dynamics of human semantic cognition |
JeYoung Jung |
| Mapping the brain circuits integrating vision and touch with high resolution imaging |
Elisa Zamboni |
| Neurochemical changes in response to human errors and shifts in attention |
Claudia Danielmeier |
| The role of oestrogen in mediating muscle stem function in women |
Sophie Joanisse |
| What makes endothelial cells start growing? Interactions between transcription factors and microtubules |
Andrew Benest |
| Differentiation of human amniotic epithelial stem cells into beta islet cells using conditional cellular reprogramming |
Abdolrahman Shams Nateri |