Publications in the Biomolecular Science and Medicinal Chemistry Division

Content: OLIVA, MARIA LUIZA VILELA, DREVENY, INGRID and EMSLEY, JONAS, 2020. Exosites expedite blood coagulation JOURNAL OF BIOLOGICAL CHEMISTRY. 295(45), 15208-15209

Content: KAIRA, BUBACARR G., SLATER, ALEXANDRE, MCCRAE, KEITH R., DREVENY, INGRID, SUMYA, UMMAY, MUTCH, NICOLA J., SEARLE, MARK and EMSLEY, JONAS, 2020. Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery BLOOD. 136(14), 1685-1697

Content: GUNNELL, EMMA A., AL-NOORI, ALAA, MUHSEN, USAMA, DAVIES, CLARE C., DOWDEN, JAMES and DREVENY, INGRID, 2020. Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4) BIOCHEMICAL JOURNAL. 477(4), 787-800

Content: GROSSMAN, SCOTT, SOUKARIEH, FADI, RICHARDSON, WILLIAM, LIU, RUILING, MASHABI, ALAA, EMSLEY, JONAS, WILLIAMS, PAUL, CAMARA, MIGUEL and STOCKS, MICHAEL J, 2020. Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR. European Journal of Medicinal Chemistry. 208, 112778

Content: SOU, T., SOUKARIEH, F., WILLIAMS, P., STOCKS, M.J., C'AMARA, M. and BERGSTR'OM, C.A.S., 2020. Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary Suspensions ACS Omega.

Content: SOUKARIEH, FADI, LIU, RUILING, ROMERO, MANUEL, ROBERSTON, SHAUN N, RICHARDSON, WILLIAM, LUCANTO, SIMONE, OTON, EDUARD VICO, QUDUS, NAIM RUHUL, MASHABI, ALAA, GROSSMAN, SCOTT, ALI, SADIQUR, SOU, TOM'AS, KUKAVICA-IBRULJ, IRENA, LEVESQUE, ROGER C, BERGSTR'OM, CHRISTEL A S, HALLIDAY, NIGEL, MISTRY, SHAILESH N, EMSLEY, JONAS, HEEB, STEPHAN, WILLIAMS, PAUL, C'AMARA, MIGUEL and STOCKS, MICHAEL J, 2020. Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa Frontiers in Chemistry. 8, 204

Content: GREEN, JACK P., SWANTON, TESSA, MORRIS, LUCY, V, EL-SHARKAWY, LINA Y., COOK, JAMES, YU, SHI, BESWICK, JAMES, ADAMSON, ANTONY D., HUMPHREYS, NEIL E., BRYCE, RICHARD, FREEMAN, SALLY, LAWRENCE, CATHERINE and BROUGH, DAVID, 2020. LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation ELIFE. 9,

Content: SWANTON, TESSA, BESWICK, JAMES A., HAMMADI, HALAH, MORRIS, LUCY, WILLIAMS, DANIEL, DE CESCO, STEPHANE, EL-SHARKAWY, LINA, YU, SHI, GREEN, JACK, DAVIS, JOHN B., LAWRENCE, CATHERINE B., BROUGH, DAVID and FREEMAN, SALLY, 2020. Selective inhibition of the K+ efflux sensitive NLRP3 pathway by Cl- channel modulation CHEMICAL SCIENCE. 11(43), 11720-11728

Content: SOFIE YE, RAFAEL W. HARTMANN, MARCUS SÖDERSTRÖM, MOHAMMAD A. AMIN, BOBO SKILLINGHAUG, LUKE S. SCHEMBRI* and LUKE R. ODELL*, 2020. Turning Information Dissipation into Dissemination: Instagram as a Communication Enhancing Tool during the COVID-19 Pandemic and Beyond Journal of Chemical Education. 97(9), 3217-3222

Content: LI C, VOOS KM, PATHAK M, HALL G, MCCRAE KR, DREVENY I, LI R and EMSLEY J, 2019. Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI. Journal of thrombosis and haemostasis : JTH. (In Press.)

Content: PATHAK M, MANNA R, LI C, KAIRA BG, HAMAD BK, BELVISO BD, BONTURI CR, DREVENY I, FISCHER PM, DEKKER LV, OLIVA MLV and EMSLEY J, 2019. Crystal structures of the recombinant β-factor XIIa protease with bound Thr-Arg and Pro-Arg substrate mimetics. Acta crystallographica. Section D, Structural biology. 75(Pt 6), 578-591

Content: PETRI A, KIM HJ, XU Y, DE GROOT R, LI C, VANDENBULCKE A, VANHOORELBEKE K, EMSLEY J and CRAWLEY JTB, 2019. Crystal structure and substrate-induced activation of ADAMTS13. Nature communications. 10(1), 3781

Content: MORGAN J, SALEEM M, NG R, ARMSTRONG C, WONG SS, CAULTON SG, FICKLING A, WILLIAMS HEL, MUNDAY AD, LÓPEZ JA, SEARLE MS and EMSLEY J, 2019. Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib. Blood advances. 3(9), 1450-1459

Content: SCHMAIER AH, EMSLEY J, FEENER EP, GAILANI D, GOVERS-RIEMSLAG JWP, KAPLAN AP, MAAS C, MORRISSEY JH, RENNÉ T, SIDELMANN JJ and MEIJERS JCM, 2019. Nomenclature of factor XI and the contact system. Journal of thrombosis and haemostasis : JTH. (In Press.)

Content: KARDEBY C, FÄLKER K, HAINING EJ, CRIEL M, LINDKVIST M, BARROSO R, PÅHLSSON P, LJUNGBERG LU, TENGDELIUS M, RAINGER GE, WATSON S, EBLE JA, HOYLAERTS MF, EMSLEY J, KONRADSSON P, WATSON SP, SUN Y and GRENEGÅRD M, 2019. Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα. Blood advances. 3(3), 275-287

Publications