Latest publication reviews the use of high-throughput screening in biomaterials discovery
In nature, cells interact closely with their surroundings, reacting to changes in their micro-environment and responding to external signals. In a similar manner, it is now well-demonstrated that there is a close relation between a material’s features and the biological response it can evoke. The study of the interactions between cells and artificial materials, also known as materiobiology, is therefore crucial in the development of materials for clinical applications. From the development of novel implants, to biomedical devices or tissue engineering scaffolds, the material’s features are directly responsible for the biological response.
Due to the large amount of possible materials available, conventional scientific approaches have shown to be incapable of successfully screening all possibilities and identifying the optimal cellular responses. Therefore, High-throughput screening (HTS) has been introduced to biomaterial discovery as the most efficient and effective way to test large libraries of materials in parallel, generating large datasets of material properties correlated to cellular response.
This article is a highly comprehensive review of the use of HTS in biomaterial discovery for biological and clinical applications. First, materiobiology is defined and presented as a scientific field, followed by an in-depth report of the techniques and recent progress for 2D/3D gradient and microarray HTS platforms. Finally, the authors present The Compendium for Biomaterial Transcriptomics (a public database for the storage and dissemination of biomaterial discovery datasets), and discuss the potential use of large datasets generated by biomaterial discovery HTS platforms to improve on biomaterial development for clinical use.
The full article can be read in the journal Chemical Reviews.
High-Throughput Methods in the Discovery and Study of Biomaterials and Materiobiology
Liangliang Yang, Sara Pijuan-Galito, Hoon Suk Rho, Aliaksei S. Vasilevich, Aysegul Dede Eren, Lu Ge, Pamela Habibović, Morgan Alexander, Jan de Boer, Aurelie Carlier, Patrick van Rijn and Qihui Zhou.
Chemical Reviews 2021, 0752
https://dx.doi.org/10.1021/acs.chemrev.0c00752
Posted on Friday 12th March 2021