The Future Investigators of Regenerative Medicine (FIRM) symposium took place on 24-27 September 2018 in Spain. Dr Laurence Burroughs gave a talk entitled: 'The ChemoTopoChip: Combinatorial Material-Topography Screening.'
Using biomaterial surface topography to influence cell fate and attachment is an emerging field. High-throughput material screening with polymer microarrays are limited to planar, non-native cell environment. The TopoChip (developed by de Boer et al), has been used to assess the impact of micro-topographies on cell attachment and fate. The ChemoTopoChip has been developed which allows simultaneous screening of multiple chemistries and micro-topographies on one chip. The ChemoTopoChip has been used to identify bioactive chemistry-topography combinations capable of directing macrophage polarisation and human mesenchymal stem cell differentiation, confirming this platform as a next generation biomaterials screening tool.
Laurence is a PostDoctoral Research Fellow in the School of Pharmacy, Advanced Materials and Healthcare Technologies Division. Laurence joined the EPSRC Programme Grant in Next Generation Biomaterials Discovery in 2017 working on combinatorial screening of biomaterial surface chemistry and topography in Research Challenge 1: Moving from 2D to 3D Materials Discovery Methods.
Future Investigators of Regenerative Medicine (FIRM) symposium
The University of Nottingham University Park Nottingham, NG7 2RD
telephone: +44 (0) 115 846 6246 email: Elizabet.Hudson@nottingham.ac.uk