The Nottingham Hearing and Tinnitus BioResource represents our effort to begin leveraging the power of large, open, accessible datasets towards transforming the way we treat and manage hearing loss and hearing-related conditions in future.
Large-scale datasets, such as the UK Biobank and the Human Connectome Project, have proved extremely powerful for facilitating research into mechanisms of human health and disease. However, a limitation of existing datasets is that hearing health phenotypes are captured at a rudimentary level, with even basic pure tone audiometry data rarely being available. This severely limits the scope of the questions that can be asked of these datasets from an auditory perspective.
The aim of the BioResource is to extensively phenotype participants using: a battery of tests, to measure hearing ability and ear health; a set of questionnaires to assess health, lifestyle and how hearing conditions affect daily life; and blood/hair samples to measure biomarkers and carry out genotyping. Participants will be followed as they age through periodically repeating tests and questionnaires.
The Nottingham Hearing and Tinnitus BioResource represents our effort to begin leveraging the power of large, open, accessible datasets in a way that could transform how we treat and manage hearing loss and hearing-related conditions in future.
We are planning a feasibility study for the Nottingham Hearing and Tinnitus BioResource. This will evaluate the feasibility of administering a large audiological test battery; to ensure we have the right processes in place to recruit, test, and retain enough participants to make the BioResource viable. We will assess recruitment rates through different recruitment channels, the balance of the participant set recruited (sex, age, hearing conditions), the willingness of people to carry on with a longitudinal study, and the completeness and reliability of the data.