You will study advanced modules in chemistry and drug discovery.
A final research project will apply your theoretical, computational and experimental techniques to an area of your choice.
Bioinorganic and Metal Coordination Chemistry
The aim of this module is to provide you with an understanding of coordination chemistry in the context of macrocyclic, supramolecular and bioinorganic chemistry and its applications in metal extraction and synthesis.
You will gain an appreciation of the importance of metals in biological systems, and be able to explain the relationship between the structure of the active centres of metallo-proteins and enzymes and their biological functions.
The module is assessed by a two-hour written exam.
This module aims to provide a framework for understanding the action of heterogeneous catalysts in terms of adsorption/desorption processes and for understanding catalyst promotion in terms of chemical and structural phenomenon and also describes a wide variety of homogeneous catalytic processes based on organo-transition metal chemistry.
Chemical Bonding and Reactivity
To provide a fundamental understanding of molecular structure and of the requirements for reactivity.
To introduce modern electronic structure theory and demonstrate how it can be applied to determine properties such as molecular structure, spectroscopy and reactivity.
Organometallic and Asymmetric Synthesis
This module will introduce you to a range of reagents and synthetic methodology. You will learn how to describe how it is applied to the synthesis of organic target molecules.
By the end of the module you will know how the use of protecting groups can be used to enable complex molecule synthesis and how modern palladium-mediated cross-coupling reactions can be used to synthesise useful organic molecules.
Your problem-solving and written communication skills will be developed.
Pericyclics and Reactive Intermediates
Use of frontier molecular orbital analysis to explain and predict stereochemical and regiochemical outcomes of pericyclic reactions (Woodward-Hoffmann rules etc).
Examples will be drawn from Diels-Alder reactions, cycloadditions [4+2] and [2+2], [3,3]-sigmatropic rearrangements (eg Claisen and Cope), [2,3]-sigmatropic rearrangements (eg Wittig and Mislow-Evans).
Generation and use of reactive intermediates in synthesis (ie radicals, carbenes, nitrenes).
Solids, Interfaces and Surfaces
This course aims to teach the relationship between structure and properties of solids, structure of Solids and characterisation.
It aims to teach a general introduction to Interfaces and Surfaces.
For the project, you will put into practice methods of accessing, assessing and critically appraising the chemical literature. The module will provide experience in experimental design and methodology, the recording, analysis and reporting of physical data (both in written and verbal form).
Contemporary Drug Discovery
This module explores modern approaches to drug discovery and will involve discussions on how chemical structure influences the molecular properties, biological activity, and toxicity of drugs.
Many examples from case histories of successful medicines will be used to illustrate the underlying chemical principles.
Chemical Biology and Enzymes
Students should gain a good appreciation of the applications for a range of enzymological, chemical and molecular biological techniques to probe cellular processes and catalysis at the forefront in chemical biology research.
This module represents a culmination of principles and techniques from a biophysical, molecular, biochemical and genetic perspective.
Topics in Inorganic Chemistry
This module covers inorganic mechanisms and the overarching fundamental principles of greener and sustainable chemistry as applied to processes, inorganic reaction mechanisms, and discussion on the theme of greener and sustainable chemistry
Protein Folding and Biospectroscopy
This module will develop an understanding of protein structure, stability, design and methods of structural analysis. In addition you will understand the protein folding problem and experimental approaches to the analysis of protein folding kinetics and the application of site-directed mutagenesis.
You will also be expected to develop a number of spectroscopic experimental techniques to probe protein structures.
There will be two hours of lectures a week.
Molecular Microbiology and Infections
This module focuses on the molecular biology that drives the fundamental principles behind the survival of microorganisms and their interaction with humans.
Lectures will discuss the interaction between the host and pathogens and how they drive the mechanisms of infection and immunity.
There will be two hours of lectures a week.
Lasers in Chemistry
A general introduction to lasers, including laser radiation and its properties will be given, leading to why lasers have such widespread uses in Chemistry.
The bulk of the module is devoted to selected applications, which will include some of:
- atmospheric measurements
- photochemistry and synthesis
- chemical kinetics
- spectroscopic studies of isolated molecules (stable and reactive)
- studies of van der Waals complexes
- studies of small metal clusters and nanoparticles
- time-resolved studies
Prospects for Personalised Medicine
This module aims to facilitate
(i) awareness of the types, frequency and range of individual genetic variation in proteins linked with disease prevalence and drug action
(ii) evaluation of pharmacogenetic evidence using pre-clinical case studies in cardiovascular disease, diabetes and obesity, and cancer
(iii) in depth understanding of the major class of GPCRs in man, and their wider roles as drug targets, through a focus on polymorphisms in these receptors and related proteins
(iv) evidence based understanding of the scientific challenges, risks and benefits of targeting such polymorphic variants therapeutically to deliver future medical advances.
Complementary and Alternative Medicines
To introduce the students to the issues surrounding the use of complementary and alternative medicines, including legal issues, safety issues, and interactions with drugs.