Enantioselective Rhodium-Catalyzed Coupling Reactions
A recent publication in the journal Angewandte Chemie from the Lam group describing the enantioselective three-component coupling reaction of arylboronics, 1,3-enynes and imines has recently been highlighted as “ Synfact of the Month” for February 2018.
This key reactivity underpinning this research is the generation of nucleophilic allylrhodium(I) species by alkenyl-to-allyl 1,4- rhodium(I) migration.
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Au-catalyzed biaryl coupling to generate 5- to 9-membered rings
A recent publication in the Journal of the American Chemical Society from the Ball group investigates the intramolecular gold-catalyzed arylation of arenes by aryl-trimethylsilanes has been from both mechanistic and preparative aspects.
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Total synthesis of (–)-aritasone via the ultra-high pressure hetero-Diels-Alder dimerisation of (–)-pinocarvone
Uroos, M.; Pitt, P.; Harwood, L. M.; Lewis, W.; Blake, A. J.; Hayes, C. J.
Org. Biomol. Chem. 2017, 15, 8523–8528
Palladium-catalyzed enantioselective C−H activation of aliphatic amines using chiral anionic BINOL-phosphoric acid ligands
Smalley, A. P.; Cuthbertson, J. D.; Gaunt, M. J.
J. Am. Chem. Soc. 2017, 139, 1412−1415
A More Critical Role for Silicon in the Catalytic Staudinger Amidation: Silanes as Non-Innocent Reductants,
Andrews, K.; Denton, R.M.
Chem. Commun. 2017, 53, 7971
A Practical and Catalyst-Free Trifluoroethylation Reaction of Amines Using Trifluoroacetic Acid,
Andrews, K.; Faizova, R.; Denton, R.M.
Nature Commun. 2017, 8, 15913
C-H Insertion as a key step to spiro-oxetanes, scaffolds for drug discovery
Nicolle, S. M.; Nortcliffe, A.; Bartrum, H. E.; Lewis, W.; Hayes C. J.; Moody, C. J.
Chem. Eur. J. 2017, 23, 13623–13627
A laboratory-scale annular continuous flow reactor for UV photochemistry using excimer lamps for discrete wavelength excitation and its use in a wavelength study of a photodecarboxlyative cyclisation
Delaney, E. N.; Lee D. S.; Elliott, L. D.; Jin, J.; Booker-Milburn, K. I.; Poliakoff, M.; George, M. W.
Green Chemistry 2017, 19(6), 1431-1438
Kinetic Analysis of Copper(I)/Feringa-Phosphoramidite Catalysed AlEt3 1,4-Addition to Cyclohex-2-en-1-one,
Willcox D.; Nouch R.; Kingsbury A.; Robinson D.; Carey J. V.; Brough S.; Woodward S.
ACS Catalysis 2017, 7, 6901-6908