Publications in the Biomolecular Science and Medicinal Chemistry Division

Content: AHMED M, CHAUDHARI K, BABAEI-JADIDI R, DEKKER LV and NATERI AS, 2017. Emerging Drugs Targeting Epithelial Cancer Stem-like Cells: A Concise Review. Stem cells (Dayton, Ohio). 35(4), 839-850

Content: GULFAM M, MATINI T, MONTEIRO PF, RIVA R, COLLINS H, SPRIGGS K, HOWDLE SM, JÉRÔME C and ALEXANDER C, 2017. Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells. Biomaterials science.

Content: LOPES SM, SOUSA EP, BARREIRA L, MARQUES C, RODRIGUES MJ and PINHO E MELO TM, 2017. Synthesis and anti-cancer activity of chiral tetrahydropyrazolo[1,5-a]pyridine-fused steroids. Steroids. (In Press.)

Content: TARESCO, VINCENZO, LOUZAO, IRIA, SCURR, DAVID, BOOTH, JONATHAN, TREACHER, KEVIN, MCCABE, JAMES, TURPIN, ELEANOR, LAUGHTON, CHARLES A., ALEXANDER, CAMERON, BURLEY, JONATHAN C. and GARNETT, MARTIN C., 2017. Rapid Nanogram Scale Screening Method of Microarrays to Evaluate Drug-Polymer Blends Using High-Throughput Printing Technology MOLECULAR PHARMACEUTICS. 14(6), 2079-2087

Content: SALEH, MAYSAA M., LAUGHTON, CHARLES A., BRADSHAW, TRACEY D. and MOODY, CHRISTOPHER J., 2017. Development of a series of bis-triazoles as Gquadruplex ligands RSC ADVANCES. 7(75), 47297-47308

Content: EMTAGE, ABIGAIL L., MISTRY, SHAILESH N., FISCHER, PETER M., KELLAM, BARRIE and LAUGHTON, CHARLES A., 2017. GPCRs through the keyhole: the role of protein flexibility in ligand binding to beta-adrenoceptors JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS. 35(12), 2604-2619

Content: DI PIETRO, ORNELLA, JUAREZ-JIMENEZ, JORDI, MUNOZ-TORRERO, DIEGO, LAUGHTON, CHARLES A. and LUQUE, F. JAVIER, 2017. Unveiling a novel transient druggable pocket in BACE-1 through molecular simulations: Conformational analysis and binding mode of multisite inhibitors PLOS ONE. 12(5),

Content: YANG, XIAOYIN and LI, XIUYAN, 2017. Roles of mobile devices supporting international students to overcome intercultural difficulties. In: BORTHWICK, KATE, BRADLEY, LINDA and THOUËSNY, SYLVIE, eds., CALL in a climate of change: adapting to turbulent global conditions – short papers from EUROCALL 2017 1. Research-publishing.net. 339-344

Content: ZULIANI-ALVAREZ L, PICCININI AM and MIDWOOD KS, 2017. Screening for Novel Endogenous Inflammatory Stimuli Using the Secreted Embryonic Alkaline Phosphatase NF-κB Reporter Assay. Bio-protocol. 7(7),

Content: ZULIANI-ALVAREZ, L., MARZEDA, A. M., DELIGNE, C., SCHWENZER, A., MCCANN, F. E., MARSDEN, B. D., PICCININI, A. M. and MIDWOOD, K. S., 2017. Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers: Nat Commun Nat Commun. 8(1), 1595

Content: KAY, ALASDAIR G., LONG, GRACE, TYLER, GEORGE, STEFAN, ANDREI, BROADFOOT, STEPHEN J., PICCININI, ANNA M., MIDDLETON, JIM and KEHOE, OKSANA, 2017. Mesenchymal Stem Cell-Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis SCIENTIFIC REPORTS. 7,

Content: SCHWEHM C, KELLAM B, GARCES AE, HILL SJ, KINDON ND, BRADSHAW TD, LI J, MACDONALD SJ, ROWEDDER JE, STODDART LA and STOCKS MJ, 2017. Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C-C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase δ (PI3Kδ) Inhibitors. Journal of medicinal chemistry. 60(4), 1534-1554

Content: ZAPOTOCZNA, M., MURRAY, E.J., HOGAN, S., O'GARA, J.P., CHHABRA, S.R., CHAN, W.C., O'NEILL, E. and WILLIAMS, P., 2017. 5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus Journal of Antimicrobial Chemotherapy. 72(3), 744-753

Content: SCHWEHM, CAROLIN, KELLAM, BARRIE, GARCES, AIMIE E., HILL, STEPHEN J., KINDON, NICHOLAS D., BRADSHAW, TRACEY D., LI, JIN, MACDONALD, SIMON J. F., ROWEDDER, JAMES E., STODDART, LEIGH A. and STOCKS, MICHAEL J., 2017. Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C–C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase $delta$ (PI3K$delta$) Inhib Journal of Medicinal Chemistry. acs.jmedchem.6b01801

Content: PANDUGA V, STOCKS MJ and BOSQUILLON C, 2017. Ipratropium is 'luminally recycled' by an inter-play between apical uptake and efflux transporters in Calu-3 bronchial epithelial cell layers. International journal of pharmaceutics. (In Press.)

Publications