Publications in the Biomolecular Science and Medicinal Chemistry Division

Content: RYAN, COLM M, KINDLE, KARIN B, COLLINS, HILARY M and HEERY, DAVID M, 2010. SUMOylation regulates the nuclear mobility of CREB binding protein and its association with nuclear bodies in live cells. Biochemical and biophysical research communications. 391(1), 1136-41

Content: KINDLE, K.B., COLLINS, H.M. and HEERY, D.M., 2010. MOZ-TIF2-mediated destruction of CBP/p300 is blocked by calpain inhibitor 2 Leukemia. 24(7), 1359-1361

Content: CANNELL, I.G., KONG, Y.W., JOHNSTON, S.J., CHEN, M.L., COLLINS, H.M., DOBBYN, H.C., ELIA, A., KRESS, T.R., DICKENS, M., CLEMENS, M.J., HEERY, D.M., GAESTEL, M., EILERS, M., WILLIS, A.E. and BUSHELL, M., 2010. p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication Proceedings of the National Academy of Sciences of the United States of America. 107(12), 5375-5380

Content: LUKEN, B.M., WINN, L.Y.N., EMSLEY, J., LANE, D.A. and CRAWLEY, J.T.B., 2010. Brief report The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function BLOOD -NEW YORK-. VOL 115(NUMB 23), 4910-4913

Content: EMSLEY, JONAS, MCEWAN, PAUL A and GAILANI, DAVID, 2010. Structure and function of factor XI. Blood. 115(13), 2569-77

Content: HALL, G. and EMSLEY, J., 2010. Structure of human thioredoxin exhibits a large conformational change Protein Science. 19(9), 1807-1811

Content: GINGRAS, ALEXANDRE R, BATE, NEIL, GOULT, BENJAMIN T, PATEL, BIPIN, KOPP, PETRA M, EMSLEY, JONAS, BARSUKOV, IGOR L, ROBERTS, GORDON C K and CRITCHLEY, DAVID R, 2010. Central region of talin has a unique fold that binds vinculin and actin. The Journal of biological chemistry. 285(38), 29577-87

Content: WADELIN, F., FULTON, J., MCEWAN, P.A., SPRIGGS, K.A., EMSLEY, J. and HEERY, D.M., 2010. Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia Molecular Cancer. 27(9), 226

Content: GAILANI D, SUN M, CHENG Q, MATAFONOV A, TUCKER EI, GRUBER A and EMSLEY J, 2010. Evidence Against A Protein In Plasma That Is A Product Of A Factor Xi Mrna Splice Variant Missing Exons 6 And 7. Blood. 116(7), 1185-6; author reply 1186-7

Content: WANG, S., MIDGLEY, C.A., SCAËROU, F., GRABAREK, J.B., GRIFFITHS, G., JACKSON, W., KONTOPIDIS, G., MCCLUE, S.J., MCINNES, C., MEADES, C., MEZNA, M., PLATER, A., STUART, I., THOMAS, M.P., WOOD, G., CLARKE, R.G., BLAKE, D.G., ZHELEVA, D.I., LANE, D.P., JACKSON, R.C., GLOVER, D.M. and FISCHER, P.M., 2010. Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors Journal of Medicinal Chemistry. 53(11), 4367-4378

Content: WANG, S., GRIFFITHS, G., MIDGLEY, C.A., BARNETT, A.L., COOPER, M., GRABAREK, J., INGRAM, L., JACKSON, W., KONTOPIDIS, G., MCCLUE, S.J., MCINNES, C., MCLACHLAN, J., MEADES, C., MEZNA, M., STUART, I., THOMAS, M.P., ZHELEVA, D.I., LANE, D.P., JACKSON, R.C., GLOVER, D.M., BLAKE, D.G. and FISCHER, P.M., 2010. Discovery and characterization of 2-anilino-4- (thiazol-5-yl) pyrimidine transcriptional CDK inhibitors as anticancer agents Chemistry & Biology. 17(10), 1111-1121

Content: MCINTYRE, N.A., MCINNES, C., GRIFFITHS, G., BARNETT, A.L., KONTOPIDIS, G., SLAWIN, A.M.Z., JACKSON, W., THOMAS, M., ZHELEVA, D.I., WANG, S., BLAKE, D.G., WESTWOOD, N.J. and FISCHER, P.M., 2010. Design, synthesis and evaluation of 2-methyl- and 2-amino-N-aryl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amines as ring-constrained 2-anilino-4-(thiazol-5-yl)pyrimidine cyclin-dependent kinase inhibitors Journal of Medicinal Chemistry. 53(5), 2136-2145

Content: LI, C., REDDY, T.R.K., FISCHER, P.M. and DEKKER, L.V., 2010. A Cy5-labelled S100A10 tracer used to identify inhibitors of the protein interaction with Annexin A2 ASSAY and Drug Development Technologies. 8(1), 85-95

Content: SHAO, D., SEGAL, A.W. and DEKKER, L.V., 2010. Subcellular localisation of the _p40_phox component of NADPH oxidase involves direct interactions between the Phox homology domain and F-actin International Journal of Biochemistry and Cell Biology. 42(10), 1736-1743

Content: REDDY, T.R.K., LI, C., GUO, X., FISCHER, P.M. and DEKKER, L.V., 2010. Structure-based design, synthesis, and SAR exploration of pyrrole-2-one analogues as inhibitors of the annexin A2-S100A10 protein interaction: potential anti-angiogenesis therapeutics. Journal of Pharmacy and Pharmacology. 62(10), 1373-1374

Publications