Polymer synthesis, drug delivery, smart materials
Key research foci include smart materials (Adv. Mater.2015, Nature Mater 2014, Nanoscale 2014), drug and gene delivery (Mol. Ther 2015, PLosOne 2014, Small 2013, Mol. Pharmaceutics 2012), and… read more
ALAZZO, ALI, AL-NATOUR, MOHAMMAD AHMAD, SPRIGGS, KEITH, STOLNIK, SNJEZANA, GHAEMMAGHAMI, AMIR, KIM, DONG-HYUN and ALEXANDER, CAMERON, 2019. Investigating the intracellular effects of hyperbranched polycation-DNA complexes on lung cancer cells using LC-MS-based metabolite profiling MOLECULAR OMICS. 15(1), 77-87 CONTE, CLAUDIA, MASTROTTO, FRANCESCA, TARESCO, VINCENZO, TCHORYK, ALEKSANDRA, QUAGLIA, FABIANA, STOLNIK, SNJEZANA and ALEXANDER, CAMERON, 2018. Enhanced uptake in 2D-and 3D-lung cancer cell models of redox responsive PEGylated nanoparticles with sensitivity to reducing extra- and intracellular environments JOURNAL OF CONTROLLED RELEASE. 277, 126-141 MAGENNIS EP, FERNANDEZ-TRILLO F, SUI C, SPAIN SG, BRADSHAW DJ, CHURCHLEY D, MANTOVANI G, WINZER K and ALEXANDER C, 2014. Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling. Nature Materials. 13, 748-755
LUI LT, XUE X, SUI C, BROWN A, PRITCHARD DI, HALLIDAY N, WINZER K, HOWDLE SM, FERNANDEZ-TRILLO F, KRASNOGOR N and ALEXANDER C, 2013. Bacteria clustering by polymers induces the expression of quorum-sensing-controlled phenotypes. Nature Chemistry. 5(12), 1058-65
Key research foci include smart materials (Adv. Mater.2015, Nature Mater 2014, Nanoscale 2014), drug and gene delivery (Mol. Ther 2015, PLosOne 2014, Small 2013, Mol. Pharmaceutics 2012), and synthetic biology (Artificial Life 2015, Nature Chem 2013, Angew Chem Int Ed. 2012 & 2011).
Current projects are investigating controlled release of therapeutics from synthetic-biopolymer complexes and conjugates, targeted degradable polymers for anti-microbial, drug, gene and cell therapies, and smart materials for protein and cell recognition. Collaborative projects span disciplines including synthetic chemistry, pharmaceutics, cell biology, regenerative medicine, microbial resistance and synthetic biology.
Measures of Esteem
Polymer synthesis, organic magnets, self-assembly of liquid crystalline polymers and molecular imprinting