Compensated Cirrhosis Cohort in Nottingham
Baseline multi-organ MRI measures of structure and haemodynamics in the liver, spleen, heart and kidneys were collected in healthy volunteers, compensated cirrhosis (CC) and decompensated cirrhosis patients to benchmark the change in measures with disease severity. In a stable CC cohort, observed annually for 3 years, we show liver T1, liver perfusion, superior mesenteric artery flow, spleen perfusion, and renal cortex T1 (measures that predict negative liver related outcomes) have sufficient sensitivity to track disease progression.
Figure: Individual patient variation of ELF score, liver stiffness measure (LSM) and liver T1 for 11 stable compensated cirrhosis patients that had measures up to and including 3 years post baseline measures. A large variance in LSM is observed in this stable group.