Publications in the Biomolecular Science and Medicinal Chemistry Division

Content: GOULDING, JOËLLE, MISTRY, SARAH J., SOAVE, MARK, WOOLARD, JEANETTE, BRIDDON, STEPHEN J., WHITE, CARL W., KELLAM, BARRIE and HILL, STEPHEN J., 2021. Subtype selective fluorescent ligands based on ICI 118,551 to study the human β2‐adrenoceptor in CRISPR/Cas9 genome‐edited HEK293T cells at low expression levels Pharmacology Research & Perspectives. 9(3), e00779

Content: SANCHEZ-BAILON, MARIA PILAR, CHOI, SOO-YOUN, DUFFICY, ELIZABETH R., SHARMA, KARAN, MCNEE, GAVIN S., GUNNELL, EMMA, CHIANG, KELLY, SAHAY, DEBASHISH, MASLEN, SARAH, STEWART, GRANT S., SKEHEL, J. MARK, DREVENY, INGRID and DAVIES, CLARE C., 2021. Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair NATURE COMMUNICATIONS. 12(1),

Content: KAY AG, TREADWELL K, ROACH P, MORGAN R, LODGE R, HYLAND M, PICCININI AM, FORSYTH NR and KEHOE O, 2021. Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis. Int J Mol Sci..

Content: TAREK ABOUL-FADL, MOSTAFA A. HASSAN, WESAM S. QAYED and WAEL M. EL-SAYED, 2021. Novel 2-Indolinone Based derivatives Targeting Cell Cycle Checkpoint’s Proteins as Potential Anticancer Agents In: 2nd Global Virtual Conference on Pharmaceutical Sciences and Drug Development.

Content: ELVA FRIDJONSDOTTIR, REZA SHARIATGORJI, ANNA NILSSON, THEODOSIA VALLIANATOU, LUKE R. ODELL, LUKE S. SCHEMBRI, PER SVENNINGSSON, PIERRE-OLIVIER FERNAGUT, ALAN R. CROSSMAN, ERWAN BEZARD* and PER E. ANDRÉN*, 2021. Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA–induced dyskinesia Science Advances. 7(2), 1-14

Content: BLOWER, I., TONG, C., SUN, X., MURRAY, E., LUCKETT, J., CHAN, W.C., WILLIAMS, P. and HILL, P.J., 2020. Gaussia luciferase as a reporter for quorum sensing in Staphylococcus aureus Sensors. 20(15), 4305

Content: GILLIS A, GONDIN AB, KLIEWER A, SANCHEZ J, LIM HD, ALAMEIN C, MANANDHAR P, SANTIAGO M, FRITZWANKER S, SCHMIEDEL F, KATTE TA, REEKIE T, GRIMSEY NL, KASSIOU M, KELLAM B, KRASEL C, HALLS ML, CONNOR M, LANE JR, SCHULZ S, CHRISTIE MJ and CANALS M, 2020. Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists. Science signaling. 13(625),

Content: COMEO, ELEONORA, KINDON, NICHOLAS D., SOAVE, MARK, STODDART, LEIGH A., KILPATRICK, LAURA E., SCAMMELLS, PETER J., HILL, STEPHEN J. and KELLAM, BARRIE, 2020. Subtype-Selective Fluorescent Ligands as Pharmacological Research Tools for the Human Adenosine A(2A) Receptor JOURNAL OF MEDICINAL CHEMISTRY. 63(5), 2656-2672

Content: STODDART, LEIGH A., KINDON, NICHOLAS D., OTUN, OMOLADE, HARWOOD, CLARE R., PATERA, FOTEINI, VEPRINTSEV, DMITRY B., WOOLARD, JEANETTE, BRIDDON, STEPHEN J., FRANKS, HESTER A., HILL, STEPHEN J. and KELLAM, BARRIE, 2020. Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells COMMUNICATIONS BIOLOGY. 3(1),

Content: BAKER, JILLIAN G, FROMONT, CHRISTOPHE, BRUDER, MARJORIE, THOMPSON, KEVIN S J, KELLAM, BARRIE, HILL, STEPHEN J, GARDINER, SHEILA M and FISCHER, PETER M, 2020. Using Esterase Selectivity to Determine the In Vivo Duration of Systemic Availability and Abolish Systemic Side Effects of Topical β-Blockers ACS Pharmacology & Translational Science.

Content: MATOS, THIAGO KELVIN BRITO, BATISTA, PEDRO HENRIQUE JATAI, ROCHO, FERNANDA DOS REIS, VITA, DANIELA DE, PEARCE, NICHOLAS, KELLAM, BARRIE, MONTANARI, CARLOS ALBERTO and LEITÃO, ANDREI, 2020. Synthesis and Matched Molecular Pair Analysis of Covalent Reversible Inhibitors of the Cysteine Protease CPB Bioorganic & Medicinal Chemistry Letters. 30(18), 127439

Content: STEPHENSON, ZOE A, HARVEY, ROBERT F, PRYDE, KENNETH R, MISTRY, SARAH, HARDY, RACHEL E, SERRELI, RICCARDO, CHUNG, INJAE, ALLEN, TIMOTHY EH, STONELEY, MARK, MACFARLANE, MARION, FISCHER, PETER M, HIRST, JUDY, KELLAM, BARRIE and WILLIS, ANNE E, 2020. Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I. eLife. 9, e55845

Content: SOAVE, MARK, HEUKERS, RAIMOND, KELLAM, BARRIE, WOOLARD, JEANETTE, SMIT, MARTINE J, BRIDDON, STEPHEN J and HILL, STEPHEN J, 2020. Monitoring Allosteric Interactions with CXCR4 Using NanoBiT Conjugated Nanobodies Cell Chemical Biology.

Content: STODDART, LEIGH A., KINDON, NICHOLAS D., OTUN, OMOLADE, HARWOOD, CLARE R., PATERA, FOTEINI, VEPRINTSEV, DMITRY B., WOOLARD, JEANETTE, BRIDDON, STEPHEN J., FRANKS, HESTER A., HILL, STEPHEN J. and KELLAM, BARRIE, 2020. Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells Communications Biology. 3(1), 722

Content: GILLIS, ALEXANDER, GONDIN, ARISBEL B, KLIEWER, ANDREA, SANCHEZ, JULIE, LIM, HERMAN D, ALAMEIN, CLAUDIA, MANANDHAR, PREETI, SANTIAGO, MARINA, FRITZWANKER, SEBASTIAN, SCHMIDEL, FRANK, KATTE, TIMOTHY A, REEKIE, TRISTAN, GRIMSEY, NATASHA L, KASSIOU, MICHAEL, KELLAM, BARRIE, KRASEL, CORNELIUS, HALLS, MICHELLE L, CONNOR, MARK, LANE, J ROBERT, SCHULZ, STEFAN, CHRISTIE, MACDONALD J and CANALS, MERITXELL, 2020. Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists. Science signaling. 13(625), eaaz3140

Publications