Publications in the Biomolecular Science and Medicinal Chemistry Division

Content: STODDART, LEIGH A., KINDON, NICHOLAS D., OTUN, OMOLADE, HARWOOD, CLARE R., PATERA, FOTEINI, VEPRINTSEV, DMITRY B., WOOLARD, JEANETTE, BRIDDON, STEPHEN J., FRANKS, HESTER A., HILL, STEPHEN J. and KELLAM, BARRIE, 2020. Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells Communications Biology. 3(1), 722

Content: GILLIS, ALEXANDER, GONDIN, ARISBEL B, KLIEWER, ANDREA, SANCHEZ, JULIE, LIM, HERMAN D, ALAMEIN, CLAUDIA, MANANDHAR, PREETI, SANTIAGO, MARINA, FRITZWANKER, SEBASTIAN, SCHMIDEL, FRANK, KATTE, TIMOTHY A, REEKIE, TRISTAN, GRIMSEY, NATASHA L, KASSIOU, MICHAEL, KELLAM, BARRIE, KRASEL, CORNELIUS, HALLS, MICHELLE L, CONNOR, MARK, LANE, J ROBERT, SCHULZ, STEFAN, CHRISTIE, MACDONALD J and CANALS, MERITXELL, 2020. Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists. Science signaling. 13(625), eaaz3140

Content: COMEO, ELEONORA, KINDON, NICHOLAS D, SOAVE, MARK, STODDART, LEIGH A, KILPATRICK, LAURA E, SCAMMELLS, PETER J, HILL, STEPHEN J and KELLAM, BARRIE, 2020. Subtype-Selective Fluorescent Ligands as Pharmacological Research Tools for the Human Adenosine A2A Receptor. Journal of medicinal chemistry.

Content: BLOWER, I., TONG, C., SUN, X., MURRAY, E., LUCKETT, J., CHAN, W.C., WILLIAMS, P. and HILL, P.J., 2020. Gaussia luciferase as a reporter for quorum sensing in Staphylococcus aureus Sensors. 20(15), 4305

Content: OLIVA, MARIA LUIZA VILELA, DREVENY, INGRID and EMSLEY, JONAS, 2020. Exosites expedite blood coagulation JOURNAL OF BIOLOGICAL CHEMISTRY. 295(45), 15208-15209

Content: KAIRA, BUBACARR G., SLATER, ALEXANDRE, MCCRAE, KEITH R., DREVENY, INGRID, SUMYA, UMMAY, MUTCH, NICOLA J., SEARLE, MARK and EMSLEY, JONAS, 2020. Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery BLOOD. 136(14), 1685-1697

Content: GUNNELL, EMMA A., AL-NOORI, ALAA, MUHSEN, USAMA, DAVIES, CLARE C., DOWDEN, JAMES and DREVENY, INGRID, 2020. Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4) BIOCHEMICAL JOURNAL. 477(4), 787-800

Content: GROSSMAN, SCOTT, SOUKARIEH, FADI, RICHARDSON, WILLIAM, LIU, RUILING, MASHABI, ALAA, EMSLEY, JONAS, WILLIAMS, PAUL, CAMARA, MIGUEL and STOCKS, MICHAEL J, 2020. Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR. European Journal of Medicinal Chemistry. 208, 112778

Content: SOU, T., SOUKARIEH, F., WILLIAMS, P., STOCKS, M.J., C'AMARA, M. and BERGSTR'OM, C.A.S., 2020. Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary Suspensions ACS Omega.

Content: SOUKARIEH, FADI, LIU, RUILING, ROMERO, MANUEL, ROBERSTON, SHAUN N, RICHARDSON, WILLIAM, LUCANTO, SIMONE, OTON, EDUARD VICO, QUDUS, NAIM RUHUL, MASHABI, ALAA, GROSSMAN, SCOTT, ALI, SADIQUR, SOU, TOM'AS, KUKAVICA-IBRULJ, IRENA, LEVESQUE, ROGER C, BERGSTR'OM, CHRISTEL A S, HALLIDAY, NIGEL, MISTRY, SHAILESH N, EMSLEY, JONAS, HEEB, STEPHAN, WILLIAMS, PAUL, C'AMARA, MIGUEL and STOCKS, MICHAEL J, 2020. Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa Frontiers in Chemistry. 8, 204

Content: GREEN, JACK P., SWANTON, TESSA, MORRIS, LUCY, V, EL-SHARKAWY, LINA Y., COOK, JAMES, YU, SHI, BESWICK, JAMES, ADAMSON, ANTONY D., HUMPHREYS, NEIL E., BRYCE, RICHARD, FREEMAN, SALLY, LAWRENCE, CATHERINE and BROUGH, DAVID, 2020. LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation ELIFE. 9,

Content: SWANTON, TESSA, BESWICK, JAMES A., HAMMADI, HALAH, MORRIS, LUCY, WILLIAMS, DANIEL, DE CESCO, STEPHANE, EL-SHARKAWY, LINA, YU, SHI, GREEN, JACK, DAVIS, JOHN B., LAWRENCE, CATHERINE B., BROUGH, DAVID and FREEMAN, SALLY, 2020. Selective inhibition of the K+ efflux sensitive NLRP3 pathway by Cl- channel modulation CHEMICAL SCIENCE. 11(43), 11720-11728

Content: SOFIE YE, RAFAEL W. HARTMANN, MARCUS SÖDERSTRÖM, MOHAMMAD A. AMIN, BOBO SKILLINGHAUG, LUKE S. SCHEMBRI* and LUKE R. ODELL*, 2020. Turning Information Dissipation into Dissemination: Instagram as a Communication Enhancing Tool during the COVID-19 Pandemic and Beyond Journal of Chemical Education. 97(9), 3217-3222

Content: PRIEBBENOW DL, LEAVER DJ, NGUYEN N, CLEARY B, LAGIAKOS HR, SANCHEZ J, XUE L, HUANG F, SUN Y, MUJUMDAR P, MUDUDUDDLA R, VARGHESE S, TEGUH S, CHARMAN SA, WHITE KL, SHACKLEFORD DM, KATNENI K, CUELLAR M, STRASSER JM, DAHLIN JL, WALTERS MA, STREET IP, MONAHAN BJ, JARMAN KE, JOUSSET SABROUX H, FALK H, CHUNG MC, HERMANS SJ, DOWNER NL, PARKER MW, VOSS AK, THOMAS T and BAELL JB, 2020. Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. Journal of medicinal chemistry. 63(9), 4655-4684

Content: LANE JR, ABRAMYAN AM, ADHIKARI P, KEEN AC, LEE KH, SANCHEZ J, VERMA RK, LIM HD, YANO H, JAVITCH JA and SHI L, 2020. Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism. eLife. 9,

Publications