In 1998 I gained a MChem (First Class Honours) in Chemistry at New College, Oxford, and remained there to complete a DPhil in Inorganic Chemistry in 2001, under the supervision of Prof Peter Battle. I then spent two years working as a post-doc in the Materials Science Division at Argonne National Laboratory, Illinois, USA, in the laboratory of Dr John F Mitchell. I returned to the UK in 2003 to take up a Junior Research Fellowship at Jesus College, Cambridge, where I ran an independent research program in the Inorganic Chemistry sector. I moved to the Leicester School of Pharmacy at De Montfort University in 2006, as a lecturer in pharmaceutical technologies. In 2007 I was appointed to a lectureship in pharmaceutical nanotechnology here in the School of Pharmacy at Nottingham.
My research interests focus on measuring and understanding change in pharmaceutical materials. This includes changes that occur with time, temperature, position in sample, addition of solvent, etc.… read more
TRES, FRANCESCO, TREACHER, KEVIN, BOOTH, JONATHAN, HUGHES, LESLIE P., WREN, STEPHEN A. C., AYLOTT, JONATHAN W. and BURLEY, JONATHAN C., 2016. Indomethacin-Kollidon VA64 Extrudates: A Mechanistic Study of pH-Dependent Controlled Release MOLECULAR PHARMACEUTICS. 13(3), 1166-1175 TARESCO, V., CREASEY, R. G., KENNON, J., MANTOVANI, G., ALEXANDER, C., BURLEY, J. C. and GARNETT, M. C., 2016. Variation in structure and properties of poly(glycerol adipate) via control of chain branching during enzymatic synthesis POLYMER. 89, 41-49 TRES F, PATIENT JD, WILLIAMS PM, TREACHER K, BOOTH J, HUGHES LP, WREN SAC, AYLOTT JW and BURLEY JC, 2015. Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping. Molecular pharmaceutics. 12(5), 1512-1522
SHABAN KHALED, JONATHAN BURLEY, MORGAN ALEXANDER, JING YANG and CLIVE ROBERTS, 2015. 3D printing of tablets containing multiple drugs with defined release profiles International Journal of Pharmaceutics. 494(2), 643-650
My research interests focus on measuring and understanding change in pharmaceutical materials. This includes changes that occur with time, temperature, position in sample, addition of solvent, etc. Phenomena of interest include crystallisation, polymorphism, hydration, dehydration, mapping of components in tablets and other drug delivery vehicles, formation of salts and co-crystals, etc.
A number of experimental techniques are employed, including Raman spectroscopy/microscopy, infra-red spectroscopy, X-ray diffraction (powder and single crystal), thermal methods etc. Experimental data are often complex (multi-variate) and are interpreted with appropriate statistical methods including Principal Component Analysis.
Current projects include investigations of:
- transitions from one solid form to another (polymorphism) on heating, important for formulating medicines
- rapid spatial mapping of tablets and complex drug delivery vehicles, for quality control of medicines and understanding controlled release
- new spectroscopic methods including Transmission Raman Spectroscopy, various new applications in pharmacy
- formation and stabilisation of amorphous materials, to produce new highly soluble medicines
- 2007-present Lecturer in Pharmaceutical Nanotechnology, University of Nottingham
- 2006-2007 Lecturer in Pharmaceutical Technology, De Montfort University, Leicester
- 2006-2003 Junior Research Fellow, Jesus College and Chemistry Department, University of Cambridge
- 2003-2001 Post-doctoral researcher, Materials Science Division, Argonne National Laboratory, USA
- 2001-1998 DPhil, Department of Chemistry, University of Oxford
- 1998-1994 MChem, University of Oxford
Memberships of Committees & Professional Bodies
- Member, Royal Society of Chemistry
- B31C07: Pharmaceutical Technology
- Laboratory studies in Pharmaceutics