School of Pharmacy

Nanomaterials Formulation and Characterisation

Our research focuses on understanding how to get a particular molecular therapy into patients effectively and efficiently.

We look at new processes for formulating molecules into medicines and for understanding these formulation processes.

Examples include:

  • real-time chemical imaging and mechanistic modelling of tablet dissolution
  • micro-array formats for formulation screening at the nano-gram scale
  • stabilising amorphous solid dispersions
  • and controlling crystallisation

Characterisation approaches include:

  • spectroscopy (infra-red and Raman)
  • X-ray diffraction
  • optical imaging and image analysis
  • and thermal characterisation (differential scanning calorimetry and thermo-gravimetric analysis)

Molecular informatics approaches are also used to develop predictive models about how a particular molecule will interact with excipients in a formulation.


International Journal of Pharmaceutics 2018From Nieto-Orellana A, et. al  International Journal of Pharmaceutics. 2018;540(1):78-88

Proposed publications:

  • Alqahtani S, Roberts CJ, Stolnik S, Bosquillon C. Development of an In Vitro System to Study the Interactions of Aerosolized Drugs with Pulmonary Mucus. Pharmaceutics. 2020;12(2) Madeira do O J, Foralosso R, Yilmaz G
  • Mastrotto F, King PJS, Xerri RM, et al. Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers. Nanoscale. 2019;11(44):21155-66
  • Nieto-Orellana A, Coghlan D, Rothery M, Falcone FH, Bosquillon C, Childerhouse N, et al. Dry-powder formulations of non-covalent protein complexes with linear or miktoarm copolymers for pulmonary delivery. International Journal of Pharmaceutics. 2018;540(1):78-88

School of Pharmacy

University of Nottingham
University Park
Nottingham, NG7 2RD

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