Physiology, Pharmacology and Neuroscience

Molecular mechanisms of human health and disease

Our groundbreaking research into the fundamental mechanisms of cell physiology and pathology helps to drive our understanding of disease – and our ability to tackle it.

Here in the Division of Physiology, Pharmacology and Neuroscience, we investigate many fundamental aspects of cell function, including metabolism, gene expression, protein ubiquitination, membrane transport, cytoskeletal structure, and organelle translocation.

These processes regulate cell proliferation, morphology, differentiation, autophagy, apoptosis, drug resistance and more. By understanding them in greater depth, we can gain important insights into disease processes and make significant steps towards new treatments. As a team, we’re particularly interested in cancer, Paget’s disease, skeletal muscle atrophy and neurodegeneration.

Our work is funded by Cancer Research UK, the Medical Research Council, and the Motor Neurone Disease Association.

Molecular mechanisms of human health and disease

Research that’s making an impact

Spotlight projects

Researching animal alternatives

How we’re encouraging the use of non-animal methods as best practise.


Investigating a common bone disease

How we’re understanding the genetics of bone disease.


Using fruit flies as research tools

How we’re understanding cancer development, genetics and cell function


Key researchers in this field

Dr Andrew Bennett

Nuclear receptors and inflammation.


Dr Marios Georgiou

Cell morphogenesis.


Dr Alistair Hume

Motor proteins and organelle transport.


Dr Ian Kerr

Proteins in transmembrane flux.


Professor Rob Layfield

Dysfunction of ubiquitin-mediated processes in bones and neurones.



Physiology, Pharmacology and Neuroscience

School of Life Sciences
University of Nottingham
Medical School
Queen's Medical Centre
Nottingham NG7 2UH