Physiology, Pharmacology and Neuroscience


Integrative, collaborative research is at the heart of the Division of Physiology, Pharmacology and Neuroscience, and our neuroscience research embodies this principle. Our team’s investigations range from the study of single molecules all the way through to in vivo imaging, electrophysiology and behavioural studies.

Together, we’re exploring many fascinating aspects of neuroscience. Our programmes are focused on understanding fundamental aspects of neuronal development and healthy brain ageing, as well as investigating how normal function is disrupted in common neurological disorders. We have particular interests in the mechanisms underlying pain, neurodegenerative disease, addiction, schizophrenia, dementia and stroke.

Our work receives substantial funding from Arthritis Research UK, who support our Centre of Excellence in Arthritis Pain, as well as the Biotechnology and Biological Sciences Research Council, EU FP7, Medical Research Council, National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), the Leverhulme Trust, and the Wellcome Trust.


Research that's making an impact

World-leading research into musculoskeletal health 

Tackling chronic arthritic pain

We’re home to the pre-clinical laboratories of the Arthritis Research UK Pain Centre. There, our researchers are leading the way in understanding the mechanistic basis of chronic pain, which can have a devastating impact on arthritis patients’ quality of life.


A new class of small molecule inhibitors

The University of Nottingham spinout company Exonate, co-founded by Professor Lucy Donaldson, is developing a range of small molecule inhibitors to regulate alternative gene splicing. Already tested in the treatment of macular degeneration, they have far-reaching potential.


Spotlight projects

Validating serotonin receptor targets for pharmaceutical drug discovery in CNS disorders

How we’re understanding brain activity.


Key researchers in this field

Dr Tomas Bellamy

Calcium signalling and neuron-glial communication.


Dr Angus Brown

Energy metabolism in the brain.


Professor Victoria Chapman

Physiology and pathophysiology of nociception and treatment of pain.


Dr Federico Dajas-Bailador

Axon biology and neuron connectivity.


Professor Lucy Donaldson

Neuronal signalling in chronic pain.


Dr Tracy Farr

Pathophysiology of cerebrovascular disease.


Professor Kevin Fone

Neurobiology of central nervous system developmental disorders.


Dr Gareth Hathway

Neurobiological processes underlying pain.


Dr Madeleine King

Cognitive function in neurodevelopmental disorders, and following drug abuse.


Dr Sebastien Serres

Metabolic imaging.


Dr Maria Toledo-Rodriguez

Resilience to brain disease at the cellular and molecular level.


Dr Rebecca Trueman

Stroke and Huntington’s Disease.


Our research


School of Life Sciences



Physiology, Pharmacology and Neuroscience

School of Life Sciences
University of Nottingham
Medical School
Queen's Medical Centre
Nottingham NG7 2UH